In-vivo measurements of the dielectric properties of breast carcinoma xenografted on nude mice

Jeiwon Cho, Jeonghoon Yoon, Sungjoon Cho, Kihyun Kwon, Sungkyu Lim, Daeduk Kim, Eun Sook Lee, Chul Hwan Kim, Jin Wook Choi, Changyul Cheon, Youngwoo Kwon

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A developing method of cancer detection is to use electromagnetic waves to compare the dielectric properties of normal and cancerous tissue. Because most of the previous studies consisted of dielectric measurements taken ex-vivo, this study investigated the advantages of in-vivo measurements, obtained using the newly developed insertion-type planar probe, through the measurements of cancer (MDA MB 231), which was cultivated and implanted into the mammary fat pad of nude mice. Reflection coefficients were obtained in the broadband frequency range from 0.5 to 30 GHz, from which broadband complex permittivity data was extracted. Complex permittivity, in addition to other parameters such as conductivity and characteristic frequency, were used to make comparisons between cancerous tissue, normal muscle tissue and fat tissue, as well as comparisons between in-vivo and ex-vivo measurements. This study investigated the suitability of in-vivo cancer detection using microwaves with the newly developed insertion-type planar probe. Results showed that both sensitivity and specificity of the current method was 97%. In addition, predictive values were 99% for the positive and 94% for the negative, thus greatly enhancing the practicality of this method. In conclusion, it was demonstrated that in-vivo measurements are highly beneficial in studying the potential of microwaves as a diagnostic tool of breast cancer, especially in combination with the newly developed insertion-type planar probe.

Original languageEnglish
Pages (from-to)593-598
Number of pages6
JournalInternational Journal of Cancer
Volume119
Issue number3
DOIs
Publication statusPublished - 2006 Aug 1

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Nude Mice
Breast Neoplasms
Microwaves
Electromagnetic Radiation
Neoplasms
Adipose Tissue
Breast
Fats
Sensitivity and Specificity
Muscles

Keywords

  • Breast cancer
  • Cancer diagnosis
  • In-vivo
  • Microwaves

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

In-vivo measurements of the dielectric properties of breast carcinoma xenografted on nude mice. / Cho, Jeiwon; Yoon, Jeonghoon; Cho, Sungjoon; Kwon, Kihyun; Lim, Sungkyu; Kim, Daeduk; Lee, Eun Sook; Kim, Chul Hwan; Choi, Jin Wook; Cheon, Changyul; Kwon, Youngwoo.

In: International Journal of Cancer, Vol. 119, No. 3, 01.08.2006, p. 593-598.

Research output: Contribution to journalArticle

Cho, J, Yoon, J, Cho, S, Kwon, K, Lim, S, Kim, D, Lee, ES, Kim, CH, Choi, JW, Cheon, C & Kwon, Y 2006, 'In-vivo measurements of the dielectric properties of breast carcinoma xenografted on nude mice', International Journal of Cancer, vol. 119, no. 3, pp. 593-598. https://doi.org/10.1002/ijc.21896
Cho, Jeiwon ; Yoon, Jeonghoon ; Cho, Sungjoon ; Kwon, Kihyun ; Lim, Sungkyu ; Kim, Daeduk ; Lee, Eun Sook ; Kim, Chul Hwan ; Choi, Jin Wook ; Cheon, Changyul ; Kwon, Youngwoo. / In-vivo measurements of the dielectric properties of breast carcinoma xenografted on nude mice. In: International Journal of Cancer. 2006 ; Vol. 119, No. 3. pp. 593-598.
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