In-vivo measurements of the dielectric properties of breast carcinoma xenografted on nude mice

Jeiwon Cho, Jeonghoon Yoon, Sungjoon Cho, Kihyun Kwon, Sungkyu Lim, Daeduk Kim, Eun Sook Lee, Chul Hwan Kim, Jin Wook Choi, Changyul Cheon, Youngwoo Kwon

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    A developing method of cancer detection is to use electromagnetic waves to compare the dielectric properties of normal and cancerous tissue. Because most of the previous studies consisted of dielectric measurements taken ex-vivo, this study investigated the advantages of in-vivo measurements, obtained using the newly developed insertion-type planar probe, through the measurements of cancer (MDA MB 231), which was cultivated and implanted into the mammary fat pad of nude mice. Reflection coefficients were obtained in the broadband frequency range from 0.5 to 30 GHz, from which broadband complex permittivity data was extracted. Complex permittivity, in addition to other parameters such as conductivity and characteristic frequency, were used to make comparisons between cancerous tissue, normal muscle tissue and fat tissue, as well as comparisons between in-vivo and ex-vivo measurements. This study investigated the suitability of in-vivo cancer detection using microwaves with the newly developed insertion-type planar probe. Results showed that both sensitivity and specificity of the current method was 97%. In addition, predictive values were 99% for the positive and 94% for the negative, thus greatly enhancing the practicality of this method. In conclusion, it was demonstrated that in-vivo measurements are highly beneficial in studying the potential of microwaves as a diagnostic tool of breast cancer, especially in combination with the newly developed insertion-type planar probe.

    Original languageEnglish
    Pages (from-to)593-598
    Number of pages6
    JournalInternational Journal of Cancer
    Volume119
    Issue number3
    DOIs
    Publication statusPublished - 2006 Aug 1

    Keywords

    • Breast cancer
    • Cancer diagnosis
    • In-vivo
    • Microwaves

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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