In vivo NIRF Imaging of Tumor Targetability of Nanosized Liposomes in Tumor-Bearing Mice

Sangmin Lee, Seung Young Lee, Sangjin Park, Ju Hee Ryu, Jin Hee Na, Heebeom Koo, Kyung Eun Lee, Hyesung Jeon, Ick Chan Kwon, Kwangmeyung Kim, Seo Young Jeong

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

To optimize tumor targetability of nanosized liposomes for application as drug carriers, various liposomes are prepared by incorporating different amounts (10, 30, and 50wt%) of cationic, anionic, and PEGylated lipids into neutral lipid. In vivo near-infrared fluorescence images reveal that PEG-PE/PC liposomes display high tumor accumulation in tumor-bearing mice, while large amounts of DOTAP/PC liposomes are rapidly captured in the liver, resulting in poor tumor accumulation. These results demonstrate that optimization of the surface properties of liposomes is very important for their tumor targetability, and that in vivo imaging techniques are useful in developing and optimizing nanosized liposome-based drug carriers.

Original languageEnglish
Pages (from-to)849-856
Number of pages8
JournalMacromolecular Bioscience
Volume12
Issue number6
DOIs
Publication statusPublished - 2012 Jun

Keywords

  • Drug delivery systems
  • Imaging
  • Liposomes
  • PEGylation
  • Tumor targeting

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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