In vivo photothermal treatment by the peritumoral injection of macrophages loaded with gold nanoshells

Taeseok Daniel Yang, Wonshik Choi, Tai Hyun Yoon, Kyoung Jin Lee, Jae-Seung Lee, Jang Ho Joo, Min Goo Lee, Hong Soon Yim, Kyung Min Choi, Byoungjae Kim, Jung Joo Lee, Heejin Kim, Doh Young Lee, Kwang-Yoon Jung, Seung-Kuk Baek

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Photothermal treatment methods have been widely studied for their target specificity and potential for supplementing the limitations of conventional surgical treatments. In this study, we conducted in vivo photothermal treatments using macrophages containing nanoshells as live vectors. We injected macrophages at the peritumoral sites and observed that they had penetrated into the tumor approximately 48 hours after injection. Afterwards, we irradiated with a near-infrared laser for 2 minutes at 1 W/cm2, causing cancer cell death. Our study identified the optimal conditions of the photothermal treatment and confirmed the feasibility of its use in in vivo treatments.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalBiomedical Optics Express
Volume7
Issue number1
DOIs
Publication statusPublished - 2015 Dec 18

    Fingerprint

Keywords

  • Medical optics and biotechnology
  • Photodynamic therapy
  • Photothermal effects

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this