In vivo study of the renal protective effects of Capsosiphon fulvescens against streptozotocin-induced oxidative stress

Mi Hyun Nam, Yun Chang Koo, Chung Oui Hong, Sung Yong Yang, Se Wook Kim, Hye Lim Jung, Hwa Lee, Ji Yeon Kim, Ah Ram Han, Won Rak Son, Min Cheol Pyo, Kwang Won Lee

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Abstract

In this study, we evaluated the effect of Capsosiphon fulvescens extract (CFE) and its active compound, pheophorbide A (PhA), on diabetic kidney failure. Diabetes mellitus (DM) was induced by a single intraperitoneal injection of streptozotocin (STZ; 40 mg/kg body weight (BW)). After a week, the rats were orally administered CFE (4 and 20 mg/ kg BW) or PhA (0.2 mg/kg BW) once a day for 9 weeks. After scarification, renal tissue samples were collected for biochemical and histochemical analyses. Our study showed that the treatment with CFE and PhA significantly decreased lipid peroxidation level and the activities of glutathione peroxidase and glutathione-S-transferase (p<0.05), but it increased glutathione level and the activities of glutathione reductase, superoxide dismutase, and catalase in the renal tissues (p<0.05). The CFE- and PhA-treated rats with DM showed improved histochemical appearance and decreased abnormal glycogen accumulation. Therefore, we suggest that PhA-containing CFE could exert renal protective effects against STZ-induced oxidative stress.

Original languageEnglish
Pages (from-to)641-647
Number of pages7
JournalKorean Journal of Food Science and Technology
Volume46
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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Capsosiphon
renoprotective effect
streptozotocin
Streptozocin
in vivo studies
Oxidative Stress
oxidative stress
Body Weight
Kidney
Diabetes Mellitus
extracts
diabetes mellitus
Glutathione Reductase
body weight
Glutathione Peroxidase
Glutathione Transferase
Intraperitoneal Injections
Glycogen
Catalase
Lipid Peroxidation

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In vivo study of the renal protective effects of Capsosiphon fulvescens against streptozotocin-induced oxidative stress. / Nam, Mi Hyun; Koo, Yun Chang; Hong, Chung Oui; Yang, Sung Yong; Kim, Se Wook; Jung, Hye Lim; Lee, Hwa; Kim, Ji Yeon; Han, Ah Ram; Son, Won Rak; Pyo, Min Cheol; Lee, Kwang Won.

In: Korean Journal of Food Science and Technology, Vol. 46, No. 5, 01.01.2014, p. 641-647.

Research output: Contribution to journalArticle

Nam, Mi Hyun ; Koo, Yun Chang ; Hong, Chung Oui ; Yang, Sung Yong ; Kim, Se Wook ; Jung, Hye Lim ; Lee, Hwa ; Kim, Ji Yeon ; Han, Ah Ram ; Son, Won Rak ; Pyo, Min Cheol ; Lee, Kwang Won. / In vivo study of the renal protective effects of Capsosiphon fulvescens against streptozotocin-induced oxidative stress. In: Korean Journal of Food Science and Technology. 2014 ; Vol. 46, No. 5. pp. 641-647.
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