Incidence and 30-day mortality of peptic ulcer bleeding in Korea

Seungjin Bae, Nayoung Kim, Jung Mook Kang, Dong Sook Kim, Kyoung Min Kim, Yu Kyung Cho, Jie Hyun Kim, Sung Woo Jung, Ki Nam Shim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: To estimate the rates of peptic ulcer bleeding (PUB) incidence and the association of demographic factors with 30-day mortality after PUB. Methods: Diagnostic algorithms for PUB were derived and validated on the basis of 115 true PUB patients at one tertiary hospital in 2005, followed by estimation of age-specific PUB incidence and 30-day mortality rates, using the Korean National Health Insurance claim database. A Cox proportional hazard model was used to determine the impact of demographic factors on the 30-day mortality rate ratio (MRR) after PUB. Results: The diagnostic algorithm showed 89 and 88% positive predictive value and sensitivity, respectively. On the basis of this algorithm, the rate of PUB incidence was 22.1 per 100 000 during 2006-2007 and the age-specific incidence rate increased with advanced age. This incidence rate was more than three times higher among men than women. Among 21 107 PUB patients, the overall 30-day mortality rate was 2.15%, but it ranged from 0.83% for patients younger than 60 years to 7.65% for patients older than 80 years. The adjusted 30-day mortality rate ratio for patients older than 80 was 8.13 (95% confidence interval 6.10-10.8) compared with those younger than 60 and 7.09 (95% confidence interval 2.78-4.51) for patients with a high level of comorbidity compared with a low level of comorbidity. Conclusion: PUB incidence was higher among men and increased with advanced age. Increased 30-day mortality was observed in association with increasing age, after adjusting for comorbidity.

Original languageEnglish
Pages (from-to)675-682
Number of pages8
JournalEuropean Journal of Gastroenterology and Hepatology
Volume24
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

Fingerprint

Korea
Peptic Ulcer
Hemorrhage
Mortality
Incidence
Comorbidity
Demography
Confidence Intervals
National Health Programs
Proportional Hazards Models
Tertiary Care Centers
Databases

Keywords

  • bleeding
  • incidence
  • mortality
  • peptic ulcer

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Bae, S., Kim, N., Kang, J. M., Kim, D. S., Kim, K. M., Cho, Y. K., ... Shim, K. N. (2012). Incidence and 30-day mortality of peptic ulcer bleeding in Korea. European Journal of Gastroenterology and Hepatology, 24(6), 675-682. https://doi.org/10.1097/MEG.0b013e3283525a56

Incidence and 30-day mortality of peptic ulcer bleeding in Korea. / Bae, Seungjin; Kim, Nayoung; Kang, Jung Mook; Kim, Dong Sook; Kim, Kyoung Min; Cho, Yu Kyung; Kim, Jie Hyun; Jung, Sung Woo; Shim, Ki Nam.

In: European Journal of Gastroenterology and Hepatology, Vol. 24, No. 6, 01.06.2012, p. 675-682.

Research output: Contribution to journalArticle

Bae, S, Kim, N, Kang, JM, Kim, DS, Kim, KM, Cho, YK, Kim, JH, Jung, SW & Shim, KN 2012, 'Incidence and 30-day mortality of peptic ulcer bleeding in Korea', European Journal of Gastroenterology and Hepatology, vol. 24, no. 6, pp. 675-682. https://doi.org/10.1097/MEG.0b013e3283525a56
Bae, Seungjin ; Kim, Nayoung ; Kang, Jung Mook ; Kim, Dong Sook ; Kim, Kyoung Min ; Cho, Yu Kyung ; Kim, Jie Hyun ; Jung, Sung Woo ; Shim, Ki Nam. / Incidence and 30-day mortality of peptic ulcer bleeding in Korea. In: European Journal of Gastroenterology and Hepatology. 2012 ; Vol. 24, No. 6. pp. 675-682.
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