Incidence and Mortality Rates of Second Pancreatic Cancer among Survivors of Digestive Cancers

A Nationwide Population-Based Study

Hyeong Sik Ahn, Tae Uk Kang, Heather Swan, Min Ji Kang, Nayoung Kim, Hyun Jung Kim, Seon Mee Park

Research output: Contribution to journalArticle

Abstract

Objectives We analyzed the incidence and mortality rates of second pancreatic ductal adenocarcinoma (PDAC) among survivors of digestive cancers in South Korea. Methods We evaluated data from the Korea National Health Insurance to identify individuals with digestive cancers in 2005 to 2015. The standardized incidence ratios (SIRs) of second PDACs and survival rates were evaluated. Results Among 772,534 patients with first digestive cancers, 1696 (0.22%) developed second PDACs. The incidence of second PDACs increased until 10 years since the first cancer diagnosis. Patients with biliary tract cancers (BTCs) showed a higher incidence of second PDACs than did those with gastrointestinal cancers or hepatocellular carcinoma. In ages 20 to 49 years, SIRs (95% confidence interval) were higher in survivors of hepatocellular carcinoma (3.08; 1.04-3.08), gastric cancer (3.40; 1.90-3.40), colorectal cancer (5.00; 2.75-5.00), gallbladder cancer (58.52; 11.81-58.52), intrahepatic cholangiocarcinoma (86.99; 1.73-86.99), extrahepatic cholangiocarcinoma (89.41; 27.42-89.41), and ampulla of Vater cancer (156.78; 48.08-156.78). In ages 50 to 64 years, colorectal cancer (1.42; 1.04-1.42), gastric cancer (1.66; 1.29-1.66), and BTCs revealed higher SIRs. In ages more than 65 years, SIR was increased only in BTCs. Second PDACs revealed a more favorable prognosis than first PDACs. Conclusions Careful surveillance for second PDACs after curative treatment of BTCs and colorectal cancers should be considered.

Original languageEnglish
Pages (from-to)412-419
Number of pages8
JournalPancreas
Volume48
Issue number3
DOIs
Publication statusPublished - 2019 Mar 1

Fingerprint

Second Primary Neoplasms
Pancreatic Neoplasms
Survivors
Biliary Tract Neoplasms
Mortality
Incidence
Population
Neoplasms
Colorectal Neoplasms
Cholangiocarcinoma
Stomach Neoplasms
Hepatocellular Carcinoma
Ampulla of Vater
Gallbladder Neoplasms
Republic of Korea
Gastrointestinal Neoplasms
National Health Programs
Korea
Adenocarcinoma
Survival Rate

Keywords

  • bile duct cancer
  • incidence
  • mortality
  • pancreatic ductal adenocarcinoma
  • second primary

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Incidence and Mortality Rates of Second Pancreatic Cancer among Survivors of Digestive Cancers : A Nationwide Population-Based Study. / Ahn, Hyeong Sik; Kang, Tae Uk; Swan, Heather; Kang, Min Ji; Kim, Nayoung; Kim, Hyun Jung; Park, Seon Mee.

In: Pancreas, Vol. 48, No. 3, 01.03.2019, p. 412-419.

Research output: Contribution to journalArticle

Ahn, Hyeong Sik ; Kang, Tae Uk ; Swan, Heather ; Kang, Min Ji ; Kim, Nayoung ; Kim, Hyun Jung ; Park, Seon Mee. / Incidence and Mortality Rates of Second Pancreatic Cancer among Survivors of Digestive Cancers : A Nationwide Population-Based Study. In: Pancreas. 2019 ; Vol. 48, No. 3. pp. 412-419.
@article{74d308a87ab940ef87807e42431b4252,
title = "Incidence and Mortality Rates of Second Pancreatic Cancer among Survivors of Digestive Cancers: A Nationwide Population-Based Study",
abstract = "Objectives We analyzed the incidence and mortality rates of second pancreatic ductal adenocarcinoma (PDAC) among survivors of digestive cancers in South Korea. Methods We evaluated data from the Korea National Health Insurance to identify individuals with digestive cancers in 2005 to 2015. The standardized incidence ratios (SIRs) of second PDACs and survival rates were evaluated. Results Among 772,534 patients with first digestive cancers, 1696 (0.22{\%}) developed second PDACs. The incidence of second PDACs increased until 10 years since the first cancer diagnosis. Patients with biliary tract cancers (BTCs) showed a higher incidence of second PDACs than did those with gastrointestinal cancers or hepatocellular carcinoma. In ages 20 to 49 years, SIRs (95{\%} confidence interval) were higher in survivors of hepatocellular carcinoma (3.08; 1.04-3.08), gastric cancer (3.40; 1.90-3.40), colorectal cancer (5.00; 2.75-5.00), gallbladder cancer (58.52; 11.81-58.52), intrahepatic cholangiocarcinoma (86.99; 1.73-86.99), extrahepatic cholangiocarcinoma (89.41; 27.42-89.41), and ampulla of Vater cancer (156.78; 48.08-156.78). In ages 50 to 64 years, colorectal cancer (1.42; 1.04-1.42), gastric cancer (1.66; 1.29-1.66), and BTCs revealed higher SIRs. In ages more than 65 years, SIR was increased only in BTCs. Second PDACs revealed a more favorable prognosis than first PDACs. Conclusions Careful surveillance for second PDACs after curative treatment of BTCs and colorectal cancers should be considered.",
keywords = "bile duct cancer, incidence, mortality, pancreatic ductal adenocarcinoma, second primary",
author = "Ahn, {Hyeong Sik} and Kang, {Tae Uk} and Heather Swan and Kang, {Min Ji} and Nayoung Kim and Kim, {Hyun Jung} and Park, {Seon Mee}",
year = "2019",
month = "3",
day = "1",
doi = "10.1097/MPA.0000000000001254",
language = "English",
volume = "48",
pages = "412--419",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Incidence and Mortality Rates of Second Pancreatic Cancer among Survivors of Digestive Cancers

T2 - A Nationwide Population-Based Study

AU - Ahn, Hyeong Sik

AU - Kang, Tae Uk

AU - Swan, Heather

AU - Kang, Min Ji

AU - Kim, Nayoung

AU - Kim, Hyun Jung

AU - Park, Seon Mee

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Objectives We analyzed the incidence and mortality rates of second pancreatic ductal adenocarcinoma (PDAC) among survivors of digestive cancers in South Korea. Methods We evaluated data from the Korea National Health Insurance to identify individuals with digestive cancers in 2005 to 2015. The standardized incidence ratios (SIRs) of second PDACs and survival rates were evaluated. Results Among 772,534 patients with first digestive cancers, 1696 (0.22%) developed second PDACs. The incidence of second PDACs increased until 10 years since the first cancer diagnosis. Patients with biliary tract cancers (BTCs) showed a higher incidence of second PDACs than did those with gastrointestinal cancers or hepatocellular carcinoma. In ages 20 to 49 years, SIRs (95% confidence interval) were higher in survivors of hepatocellular carcinoma (3.08; 1.04-3.08), gastric cancer (3.40; 1.90-3.40), colorectal cancer (5.00; 2.75-5.00), gallbladder cancer (58.52; 11.81-58.52), intrahepatic cholangiocarcinoma (86.99; 1.73-86.99), extrahepatic cholangiocarcinoma (89.41; 27.42-89.41), and ampulla of Vater cancer (156.78; 48.08-156.78). In ages 50 to 64 years, colorectal cancer (1.42; 1.04-1.42), gastric cancer (1.66; 1.29-1.66), and BTCs revealed higher SIRs. In ages more than 65 years, SIR was increased only in BTCs. Second PDACs revealed a more favorable prognosis than first PDACs. Conclusions Careful surveillance for second PDACs after curative treatment of BTCs and colorectal cancers should be considered.

AB - Objectives We analyzed the incidence and mortality rates of second pancreatic ductal adenocarcinoma (PDAC) among survivors of digestive cancers in South Korea. Methods We evaluated data from the Korea National Health Insurance to identify individuals with digestive cancers in 2005 to 2015. The standardized incidence ratios (SIRs) of second PDACs and survival rates were evaluated. Results Among 772,534 patients with first digestive cancers, 1696 (0.22%) developed second PDACs. The incidence of second PDACs increased until 10 years since the first cancer diagnosis. Patients with biliary tract cancers (BTCs) showed a higher incidence of second PDACs than did those with gastrointestinal cancers or hepatocellular carcinoma. In ages 20 to 49 years, SIRs (95% confidence interval) were higher in survivors of hepatocellular carcinoma (3.08; 1.04-3.08), gastric cancer (3.40; 1.90-3.40), colorectal cancer (5.00; 2.75-5.00), gallbladder cancer (58.52; 11.81-58.52), intrahepatic cholangiocarcinoma (86.99; 1.73-86.99), extrahepatic cholangiocarcinoma (89.41; 27.42-89.41), and ampulla of Vater cancer (156.78; 48.08-156.78). In ages 50 to 64 years, colorectal cancer (1.42; 1.04-1.42), gastric cancer (1.66; 1.29-1.66), and BTCs revealed higher SIRs. In ages more than 65 years, SIR was increased only in BTCs. Second PDACs revealed a more favorable prognosis than first PDACs. Conclusions Careful surveillance for second PDACs after curative treatment of BTCs and colorectal cancers should be considered.

KW - bile duct cancer

KW - incidence

KW - mortality

KW - pancreatic ductal adenocarcinoma

KW - second primary

UR - http://www.scopus.com/inward/record.url?scp=85062718899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062718899&partnerID=8YFLogxK

U2 - 10.1097/MPA.0000000000001254

DO - 10.1097/MPA.0000000000001254

M3 - Article

VL - 48

SP - 412

EP - 419

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 3

ER -