Incidence and Prognosis of Subsequent Cholangiocarcinoma in Patients with Hepatic Resection for Bile Duct Stones

Hyun Jung Kim, Tae Uk Kang, Heather Swan, Min Ji Kang, Nayoung Kim, Hyeong Sik Ahn, Seon Mee Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and Aim: Cholangiocarcinoma (CCA) often develops after the hepatic resection for hepatolithiasis as well as indwelling it. We studied the incidence and prognosis of subsequent CCA in patients with hepatolithiasis in South Korea. Methods: We identified individuals with diagnosed CCA at the time of or after surgery, during 2002–2016, from the Korean National Health Insurance. The incidences and survival rates of subsequent CCA were analyzed and compared with concomitant CCA. The standardized incidence ratios (SIRs) of CCA in this cohort were evaluated in the standard Korean population. All data were stratified by the presence of intrahepatic or extrahepatic CCA, age and sex. Results: Of the 7852 patients with hepatectomy for BDS, 433 (5.84%) had concomitant CCA. Over the 12-year follow-up, 107 of 7419 (1.98%) patients were diagnosed with subsequent CCA. Patients with hepatic resection for BDS revealed higher SIRs for subsequent CCA (12.89, 95% CI 10.96–15.15) in cases of both intrahepatic CCA (13.40, 10.55–17.02) and extrahepatic CCA (12.42, 9.98–15.46). The median survival time for subsequent CCA was 0.87 years, while that for concomitant CCA was 2.79 years. Having subsequent CCA (HR 2.71, 95% CI 2.17–3.40) and being male (HR 1.28, 1.05–1.57) were related to a shorter survival time. The CCA site and age at CCA diagnosis were not related to prognoses. Conclusions: Subsequent CCA developed in 2% of the patients with hepatic resection for benign BDS until 10 years and was associated with poorer prognoses than concomitant CCA. Future studies focused on the long-term surveillance for CCA in such patients are needed.

Original languageEnglish
JournalDigestive Diseases and Sciences
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Cholangiocarcinoma
Bile Ducts
Liver
Incidence
Republic of Korea

Keywords

  • Bile duct stone
  • Cholangiocarcinoma
  • Hepatic resection
  • Incidence
  • Mortality

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Incidence and Prognosis of Subsequent Cholangiocarcinoma in Patients with Hepatic Resection for Bile Duct Stones. / Kim, Hyun Jung; Kang, Tae Uk; Swan, Heather; Kang, Min Ji; Kim, Nayoung; Ahn, Hyeong Sik; Park, Seon Mee.

In: Digestive Diseases and Sciences, 01.01.2018.

Research output: Contribution to journalArticle

Kim, Hyun Jung ; Kang, Tae Uk ; Swan, Heather ; Kang, Min Ji ; Kim, Nayoung ; Ahn, Hyeong Sik ; Park, Seon Mee. / Incidence and Prognosis of Subsequent Cholangiocarcinoma in Patients with Hepatic Resection for Bile Duct Stones. In: Digestive Diseases and Sciences. 2018.
@article{576e1461e5ef406db7e770bf7ebf332b,
title = "Incidence and Prognosis of Subsequent Cholangiocarcinoma in Patients with Hepatic Resection for Bile Duct Stones",
abstract = "Background and Aim: Cholangiocarcinoma (CCA) often develops after the hepatic resection for hepatolithiasis as well as indwelling it. We studied the incidence and prognosis of subsequent CCA in patients with hepatolithiasis in South Korea. Methods: We identified individuals with diagnosed CCA at the time of or after surgery, during 2002–2016, from the Korean National Health Insurance. The incidences and survival rates of subsequent CCA were analyzed and compared with concomitant CCA. The standardized incidence ratios (SIRs) of CCA in this cohort were evaluated in the standard Korean population. All data were stratified by the presence of intrahepatic or extrahepatic CCA, age and sex. Results: Of the 7852 patients with hepatectomy for BDS, 433 (5.84{\%}) had concomitant CCA. Over the 12-year follow-up, 107 of 7419 (1.98{\%}) patients were diagnosed with subsequent CCA. Patients with hepatic resection for BDS revealed higher SIRs for subsequent CCA (12.89, 95{\%} CI 10.96–15.15) in cases of both intrahepatic CCA (13.40, 10.55–17.02) and extrahepatic CCA (12.42, 9.98–15.46). The median survival time for subsequent CCA was 0.87 years, while that for concomitant CCA was 2.79 years. Having subsequent CCA (HR 2.71, 95{\%} CI 2.17–3.40) and being male (HR 1.28, 1.05–1.57) were related to a shorter survival time. The CCA site and age at CCA diagnosis were not related to prognoses. Conclusions: Subsequent CCA developed in 2{\%} of the patients with hepatic resection for benign BDS until 10 years and was associated with poorer prognoses than concomitant CCA. Future studies focused on the long-term surveillance for CCA in such patients are needed.",
keywords = "Bile duct stone, Cholangiocarcinoma, Hepatic resection, Incidence, Mortality",
author = "Kim, {Hyun Jung} and Kang, {Tae Uk} and Heather Swan and Kang, {Min Ji} and Nayoung Kim and Ahn, {Hyeong Sik} and Park, {Seon Mee}",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s10620-018-5262-6",
language = "English",
journal = "American Journal of Digestive Diseases",
issn = "0002-9211",
publisher = "Springer New York",

}

TY - JOUR

T1 - Incidence and Prognosis of Subsequent Cholangiocarcinoma in Patients with Hepatic Resection for Bile Duct Stones

AU - Kim, Hyun Jung

AU - Kang, Tae Uk

AU - Swan, Heather

AU - Kang, Min Ji

AU - Kim, Nayoung

AU - Ahn, Hyeong Sik

AU - Park, Seon Mee

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background and Aim: Cholangiocarcinoma (CCA) often develops after the hepatic resection for hepatolithiasis as well as indwelling it. We studied the incidence and prognosis of subsequent CCA in patients with hepatolithiasis in South Korea. Methods: We identified individuals with diagnosed CCA at the time of or after surgery, during 2002–2016, from the Korean National Health Insurance. The incidences and survival rates of subsequent CCA were analyzed and compared with concomitant CCA. The standardized incidence ratios (SIRs) of CCA in this cohort were evaluated in the standard Korean population. All data were stratified by the presence of intrahepatic or extrahepatic CCA, age and sex. Results: Of the 7852 patients with hepatectomy for BDS, 433 (5.84%) had concomitant CCA. Over the 12-year follow-up, 107 of 7419 (1.98%) patients were diagnosed with subsequent CCA. Patients with hepatic resection for BDS revealed higher SIRs for subsequent CCA (12.89, 95% CI 10.96–15.15) in cases of both intrahepatic CCA (13.40, 10.55–17.02) and extrahepatic CCA (12.42, 9.98–15.46). The median survival time for subsequent CCA was 0.87 years, while that for concomitant CCA was 2.79 years. Having subsequent CCA (HR 2.71, 95% CI 2.17–3.40) and being male (HR 1.28, 1.05–1.57) were related to a shorter survival time. The CCA site and age at CCA diagnosis were not related to prognoses. Conclusions: Subsequent CCA developed in 2% of the patients with hepatic resection for benign BDS until 10 years and was associated with poorer prognoses than concomitant CCA. Future studies focused on the long-term surveillance for CCA in such patients are needed.

AB - Background and Aim: Cholangiocarcinoma (CCA) often develops after the hepatic resection for hepatolithiasis as well as indwelling it. We studied the incidence and prognosis of subsequent CCA in patients with hepatolithiasis in South Korea. Methods: We identified individuals with diagnosed CCA at the time of or after surgery, during 2002–2016, from the Korean National Health Insurance. The incidences and survival rates of subsequent CCA were analyzed and compared with concomitant CCA. The standardized incidence ratios (SIRs) of CCA in this cohort were evaluated in the standard Korean population. All data were stratified by the presence of intrahepatic or extrahepatic CCA, age and sex. Results: Of the 7852 patients with hepatectomy for BDS, 433 (5.84%) had concomitant CCA. Over the 12-year follow-up, 107 of 7419 (1.98%) patients were diagnosed with subsequent CCA. Patients with hepatic resection for BDS revealed higher SIRs for subsequent CCA (12.89, 95% CI 10.96–15.15) in cases of both intrahepatic CCA (13.40, 10.55–17.02) and extrahepatic CCA (12.42, 9.98–15.46). The median survival time for subsequent CCA was 0.87 years, while that for concomitant CCA was 2.79 years. Having subsequent CCA (HR 2.71, 95% CI 2.17–3.40) and being male (HR 1.28, 1.05–1.57) were related to a shorter survival time. The CCA site and age at CCA diagnosis were not related to prognoses. Conclusions: Subsequent CCA developed in 2% of the patients with hepatic resection for benign BDS until 10 years and was associated with poorer prognoses than concomitant CCA. Future studies focused on the long-term surveillance for CCA in such patients are needed.

KW - Bile duct stone

KW - Cholangiocarcinoma

KW - Hepatic resection

KW - Incidence

KW - Mortality

UR - http://www.scopus.com/inward/record.url?scp=85053381324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053381324&partnerID=8YFLogxK

U2 - 10.1007/s10620-018-5262-6

DO - 10.1007/s10620-018-5262-6

M3 - Article

C2 - 30171402

AN - SCOPUS:85053381324

JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

ER -