Incidence and risk factors for macular hemorrhage following intravitreal ranibizumab injection for neovascular age-related macular degeneration

Sang Woong Moon, Jaeryung Oh, Hyeong Gon Yu, Hee Yoon Cho, Su Jeong Song

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Purpose: To analyze the incidence of and risk factors for newly developed or increased macular hemorrhage after intravitreal ranibizumab injection (IVR) for neovascular age-related macular degeneration (AMD). Methods: We performed a retrospective chart review of 220 subjects (220 eyes) from 5 hospitals who received IVRs for neovascular AMD between 1 June 2009 and 30 June 2010. Systemic conditions (age, sex, presence of diabetes, hypertension, cardiovascular disease, smoking, and use of anticoagulation agent) and presence of hemorrhage at the initial exam were evaluated. The primary study outcome was the incidence of newly developed or increased macular hemorrhage during the 1-month postinjection period. Results: The incidence of newly developed or increased macular hemorrhage including vitreous hemorrhage was 8% (18/220). Presence of diabetes was found to be a risk factor for macular hemorrhage [odds ratios (OR): 2.16, 95% confidence intervals (CI): 1.07-8.13]. When subjects had both diabetes and hypertension, the risk of macular hemorrhage after injection increased 4.8-fold (OR: 4.84, CI: 1.24-18.85). Conclusion: The systemic condition of subjects was found to be an important risk factor for newly developed or increased macular hemorrhage after IVR for neovascular AMD. More consideration should be given to the status of diabetes and hypertension in subjects who receive ranibizumab for neovascular AMD.

    Original languageEnglish
    Pages (from-to)556-559
    Number of pages4
    JournalJournal of Ocular Pharmacology and Therapeutics
    Volume29
    Issue number6
    DOIs
    Publication statusPublished - 2013 Jul 1

    ASJC Scopus subject areas

    • Ophthalmology
    • Pharmacology
    • Pharmacology (medical)

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