Incidence and risk factors of chronic kidney disease in Korean patients with T1a renal cell carcinoma before and after radical or partial nephrectomy

Sung Han Kim, Sang Eun Lee, Sung Kyu Hong, Chang Wook Jeong, Yong Hyun Park, Yong June Kim, Seok Ho Kang, Sung Hoo Hong, Won Suk Choi, Seok Soo Byun

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: The aim of the study was to investigate the incidence of chronic kidney disease in patients with T1a renal cell carcinoma both before and after partial or radical nephrectomy, and to assess risk factors for chronic kidney disease. Methods: From January 2001 to December 2011, 1928 patients with a single renal mass ≤ 4 cm undergoing partial nephrectomy or radical nephrectomy with the existence of a normal contralateral kidney were retrospectively reviewed for the evaluation of preoperative chronic kidney disease, and reviewed only 1676 patients for the postoperative chronic kidney disease. The estimated glomerular filtration rates were used to define chronic kidney disease ≤60 ml/min/1.73 m2 by the Modification of Diet in Renal Disease equation. Demographics and clinicopathological parameters were evaluated to determine the risk factors with the development of chronic kidney disease both before and after surgery. Results: Chronic kidney disease was found preoperatively in 10.0% (n = 192) of patients; 16.1% (n = 269) of patients developed chronic kidney disease postoperatively, including 102 (6.1%) chronic kidney disease patients .65 years of age. Between the non-chronic kidney disease and chronic kidney disease patients, male gender (odds ratio 3.55 vs. 3.78, respectively) and diagnostic age (odds ratio 1.04 vs. 1.05) were significantly distinctive common risk factors for chronic kidney disease both before and after surgery (P < 0.002). In addition, hypertension (odds ratio 0.46), serum albumin (odds ratio 0.23) and calcium (odds ratio 2.06) were significant as preoperative risk factors (P < 0.015), and preoperative serum creatinine (odds ratio 1.90) and surgical type ( partial nephrectomy or radical nephrectomy; odds ratio 11.89) were significant as postoperative risk factors (P < 0.030). Conclusions: Old, male hypertensive patients with a small renal mass would be better candidates for partial nephrectomy to prevent postoperative chronic kidney disease.

Original languageEnglish
Article numberhyt149
Pages (from-to)1243-1248
Number of pages6
JournalJapanese Journal of Clinical Oncology
Volume43
Issue number12
DOIs
Publication statusPublished - 2013 Dec 1

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Nephrectomy
Chronic Renal Insufficiency
Renal Cell Carcinoma
Incidence
Odds Ratio
Kidney
Diet Therapy
Kidney Diseases
Glomerular Filtration Rate
Serum Albumin
Creatinine
Demography
Hypertension
Calcium

Keywords

  • Carcinoma
  • Chronic
  • Incidence
  • Nephrectomy
  • Renal cell
  • Renal insufficiency
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Incidence and risk factors of chronic kidney disease in Korean patients with T1a renal cell carcinoma before and after radical or partial nephrectomy. / Kim, Sung Han; Lee, Sang Eun; Hong, Sung Kyu; Jeong, Chang Wook; Park, Yong Hyun; Kim, Yong June; Kang, Seok Ho; Hong, Sung Hoo; Choi, Won Suk; Byun, Seok Soo.

In: Japanese Journal of Clinical Oncology, Vol. 43, No. 12, hyt149, 01.12.2013, p. 1243-1248.

Research output: Contribution to journalArticle

Kim, Sung Han ; Lee, Sang Eun ; Hong, Sung Kyu ; Jeong, Chang Wook ; Park, Yong Hyun ; Kim, Yong June ; Kang, Seok Ho ; Hong, Sung Hoo ; Choi, Won Suk ; Byun, Seok Soo. / Incidence and risk factors of chronic kidney disease in Korean patients with T1a renal cell carcinoma before and after radical or partial nephrectomy. In: Japanese Journal of Clinical Oncology. 2013 ; Vol. 43, No. 12. pp. 1243-1248.
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AU - Kim, Sung Han

AU - Lee, Sang Eun

AU - Hong, Sung Kyu

AU - Jeong, Chang Wook

AU - Park, Yong Hyun

AU - Kim, Yong June

AU - Kang, Seok Ho

AU - Hong, Sung Hoo

AU - Choi, Won Suk

AU - Byun, Seok Soo

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N2 - Objective: The aim of the study was to investigate the incidence of chronic kidney disease in patients with T1a renal cell carcinoma both before and after partial or radical nephrectomy, and to assess risk factors for chronic kidney disease. Methods: From January 2001 to December 2011, 1928 patients with a single renal mass ≤ 4 cm undergoing partial nephrectomy or radical nephrectomy with the existence of a normal contralateral kidney were retrospectively reviewed for the evaluation of preoperative chronic kidney disease, and reviewed only 1676 patients for the postoperative chronic kidney disease. The estimated glomerular filtration rates were used to define chronic kidney disease ≤60 ml/min/1.73 m2 by the Modification of Diet in Renal Disease equation. Demographics and clinicopathological parameters were evaluated to determine the risk factors with the development of chronic kidney disease both before and after surgery. Results: Chronic kidney disease was found preoperatively in 10.0% (n = 192) of patients; 16.1% (n = 269) of patients developed chronic kidney disease postoperatively, including 102 (6.1%) chronic kidney disease patients .65 years of age. Between the non-chronic kidney disease and chronic kidney disease patients, male gender (odds ratio 3.55 vs. 3.78, respectively) and diagnostic age (odds ratio 1.04 vs. 1.05) were significantly distinctive common risk factors for chronic kidney disease both before and after surgery (P < 0.002). In addition, hypertension (odds ratio 0.46), serum albumin (odds ratio 0.23) and calcium (odds ratio 2.06) were significant as preoperative risk factors (P < 0.015), and preoperative serum creatinine (odds ratio 1.90) and surgical type ( partial nephrectomy or radical nephrectomy; odds ratio 11.89) were significant as postoperative risk factors (P < 0.030). Conclusions: Old, male hypertensive patients with a small renal mass would be better candidates for partial nephrectomy to prevent postoperative chronic kidney disease.

AB - Objective: The aim of the study was to investigate the incidence of chronic kidney disease in patients with T1a renal cell carcinoma both before and after partial or radical nephrectomy, and to assess risk factors for chronic kidney disease. Methods: From January 2001 to December 2011, 1928 patients with a single renal mass ≤ 4 cm undergoing partial nephrectomy or radical nephrectomy with the existence of a normal contralateral kidney were retrospectively reviewed for the evaluation of preoperative chronic kidney disease, and reviewed only 1676 patients for the postoperative chronic kidney disease. The estimated glomerular filtration rates were used to define chronic kidney disease ≤60 ml/min/1.73 m2 by the Modification of Diet in Renal Disease equation. Demographics and clinicopathological parameters were evaluated to determine the risk factors with the development of chronic kidney disease both before and after surgery. Results: Chronic kidney disease was found preoperatively in 10.0% (n = 192) of patients; 16.1% (n = 269) of patients developed chronic kidney disease postoperatively, including 102 (6.1%) chronic kidney disease patients .65 years of age. Between the non-chronic kidney disease and chronic kidney disease patients, male gender (odds ratio 3.55 vs. 3.78, respectively) and diagnostic age (odds ratio 1.04 vs. 1.05) were significantly distinctive common risk factors for chronic kidney disease both before and after surgery (P < 0.002). In addition, hypertension (odds ratio 0.46), serum albumin (odds ratio 0.23) and calcium (odds ratio 2.06) were significant as preoperative risk factors (P < 0.015), and preoperative serum creatinine (odds ratio 1.90) and surgical type ( partial nephrectomy or radical nephrectomy; odds ratio 11.89) were significant as postoperative risk factors (P < 0.030). Conclusions: Old, male hypertensive patients with a small renal mass would be better candidates for partial nephrectomy to prevent postoperative chronic kidney disease.

KW - Carcinoma

KW - Chronic

KW - Incidence

KW - Nephrectomy

KW - Renal cell

KW - Renal insufficiency

KW - Risk factors

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