TY - JOUR
T1 - Incidence and risk factors of postoperative pneumonia following cancer surgery in adult patients with selected solid cancer
T2 - results of “Cancer POP” study
AU - Jung, Jiwon
AU - Moon, Song Mi
AU - Jang, Hee Chang
AU - Kang, Cheol In
AU - Jun, Jae Bum
AU - Cho, Yong Kyun
AU - Kang, Seung Ji
AU - Seo, Bo Jeong
AU - Kim, Young Joo
AU - Park, Seong Beom
AU - Lee, Juneyoung
AU - Yu, Chang Sik
AU - Kim, Sung Han
N1 - Funding Information:
This research was sponsored by Pfizer Korea.
Publisher Copyright:
© 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
PY - 2018/1
Y1 - 2018/1
N2 - The aim of this study was to investigate the incidence and risk factors of postoperative pneumonia (POP) within 1 year after cancer surgery in patients with the five most common cancers (gastric, colorectal, lung, breast cancer, and hepatocellular carcinoma [HCC]) in South Korea. This was a multicenter and retrospective cohort study performed at five nationwide cancer centers. The number of cancer patients in each center was allocated by the proportion of cancer surgery. Adult patients were randomly selected according to the allocated number, among those who underwent cancer surgery from January to December 2014 within 6 months after diagnosis of cancer. One-year cumulative incidence of POP was estimated using Kaplan–Meier analysis. An univariable Cox's proportional hazard regression analysis was performed to identify risk factors for POP development. As a multivariable analysis, confounders were adjusted using multiple Cox's PH regression model. Among the total 2000 patients, the numbers of patients with gastric cancer, colorectal cancer, lung cancer, breast cancer, and HCC were 497 (25%), 525 (26%), 277 (14%), 552 (28%), and 149 (7%), respectively. Overall, the 1-year cumulative incidence of POP was 2.0% (95% CI, 1.4–2.6). The 1-year cumulative incidences in each cancer were as follows: lung 8.0%, gastric 1.8%, colorectal 1.0%, HCC 0.7%, and breast 0.4%. In multivariable analysis, older age, higher Charlson comorbidity index (CCI) score, ulcer disease, history of pneumonia, and smoking were related with POP development. In conclusions, the 1-year cumulative incidence of POP in the five most common cancers was 2%. Older age, higher CCI scores, smoker, ulcer disease, and previous pneumonia history increased the risk of POP development in cancer patients.
AB - The aim of this study was to investigate the incidence and risk factors of postoperative pneumonia (POP) within 1 year after cancer surgery in patients with the five most common cancers (gastric, colorectal, lung, breast cancer, and hepatocellular carcinoma [HCC]) in South Korea. This was a multicenter and retrospective cohort study performed at five nationwide cancer centers. The number of cancer patients in each center was allocated by the proportion of cancer surgery. Adult patients were randomly selected according to the allocated number, among those who underwent cancer surgery from January to December 2014 within 6 months after diagnosis of cancer. One-year cumulative incidence of POP was estimated using Kaplan–Meier analysis. An univariable Cox's proportional hazard regression analysis was performed to identify risk factors for POP development. As a multivariable analysis, confounders were adjusted using multiple Cox's PH regression model. Among the total 2000 patients, the numbers of patients with gastric cancer, colorectal cancer, lung cancer, breast cancer, and HCC were 497 (25%), 525 (26%), 277 (14%), 552 (28%), and 149 (7%), respectively. Overall, the 1-year cumulative incidence of POP was 2.0% (95% CI, 1.4–2.6). The 1-year cumulative incidences in each cancer were as follows: lung 8.0%, gastric 1.8%, colorectal 1.0%, HCC 0.7%, and breast 0.4%. In multivariable analysis, older age, higher Charlson comorbidity index (CCI) score, ulcer disease, history of pneumonia, and smoking were related with POP development. In conclusions, the 1-year cumulative incidence of POP in the five most common cancers was 2%. Older age, higher CCI scores, smoker, ulcer disease, and previous pneumonia history increased the risk of POP development in cancer patients.
KW - Breast cancer
KW - colorectal cancer
KW - gastric cancer
KW - hepatocellular carcinoma
KW - lung cancer
KW - postoperative pneumonia
UR - http://www.scopus.com/inward/record.url?scp=85038816537&partnerID=8YFLogxK
U2 - 10.1002/cam4.1259
DO - 10.1002/cam4.1259
M3 - Article
C2 - 29271081
AN - SCOPUS:85038816537
VL - 7
SP - 261
EP - 269
JO - Cancer Medicine
JF - Cancer Medicine
SN - 2045-7634
IS - 1
ER -