Incidence, mortality, and causes of death in physician-diagnosed primary Sjögren's syndrome in Korea: A nationwide, population-based study

Hyun Jung Kim, Kyoung Hoon Kim, Hoo Jae Hann, Seungjin Han, Yuri Kim, Sang Hyuk Lee, Dong Sook Kim, Hyeong Sik Ahn

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives The objective of this study was to investigate the epidemiological features of primary Sjögren's syndrome (pSS) in Korea at a national level, including the incidence, mortality, and causes of death. Methods We used a national, population-based registry database called the Rare Intractable Disease Registration Program from the Health Insurance Review and Assessment Service to obtain pSS patient data for the period between 2010 and 2014. pSS was diagnosed by a physician based on uniform criteria. We also used data from Statistics Korea to confirm the mortality and causes of death. Results Between 2010 and 2014, the total number of patients newly diagnosed with pSS was 5891, resulting in an annual incidence of 2.34 per 100,000 individuals. The female-to-male ratio was 14.5:1. A total of 114 pSS patients died during the study period. The overall survival rate of pSS patients was 99.0%, and the 1-year, 2-year, and 5-year survival rates were 98.7%, 98.1%, and 97.1%, respectively, and the standardized mortality ratio (SMR) was 1.47 (2.14 for males and 1.35 for females). The most common causes of death were respiratory disease (n = 25; 21.9%) followed by circulatory diseases (n = 21; 18.4%), musculoskeletal connective tissue diseases (n = 21; 18.4%), and cancer (n=19; 16.7%). Conclusions The national incidence of pSS in Korea presented in this study was lower in comparison with reports from other countries. However, the mortality rate was significantly higher than the corresponding values in the age- and gender-matched general population. The higher mortality in pSS patients is attributable to respiratory diseases and lung cancer.

Original languageEnglish
Pages (from-to)222-227
Number of pages6
JournalSeminars in Arthritis and Rheumatism
Volume47
Issue number2
DOIs
Publication statusPublished - 2017 Oct 1

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Korea
Cause of Death
Physicians
Mortality
Incidence
Population
Survival Rate
Connective Tissue Diseases
Health Insurance
Rare Diseases
Registries
Lung Neoplasms
Databases
Neoplasms

Keywords

  • Causes of death
  • Epidemiology
  • Mortality
  • Primary Sjögren's
  • syndrome

ASJC Scopus subject areas

  • Rheumatology
  • Anesthesiology and Pain Medicine

Cite this

Incidence, mortality, and causes of death in physician-diagnosed primary Sjögren's syndrome in Korea : A nationwide, population-based study. / Kim, Hyun Jung; Kim, Kyoung Hoon; Hann, Hoo Jae; Han, Seungjin; Kim, Yuri; Lee, Sang Hyuk; Kim, Dong Sook; Ahn, Hyeong Sik.

In: Seminars in Arthritis and Rheumatism, Vol. 47, No. 2, 01.10.2017, p. 222-227.

Research output: Contribution to journalArticle

Kim, Hyun Jung ; Kim, Kyoung Hoon ; Hann, Hoo Jae ; Han, Seungjin ; Kim, Yuri ; Lee, Sang Hyuk ; Kim, Dong Sook ; Ahn, Hyeong Sik. / Incidence, mortality, and causes of death in physician-diagnosed primary Sjögren's syndrome in Korea : A nationwide, population-based study. In: Seminars in Arthritis and Rheumatism. 2017 ; Vol. 47, No. 2. pp. 222-227.
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abstract = "Objectives The objective of this study was to investigate the epidemiological features of primary Sj{\"o}gren's syndrome (pSS) in Korea at a national level, including the incidence, mortality, and causes of death. Methods We used a national, population-based registry database called the Rare Intractable Disease Registration Program from the Health Insurance Review and Assessment Service to obtain pSS patient data for the period between 2010 and 2014. pSS was diagnosed by a physician based on uniform criteria. We also used data from Statistics Korea to confirm the mortality and causes of death. Results Between 2010 and 2014, the total number of patients newly diagnosed with pSS was 5891, resulting in an annual incidence of 2.34 per 100,000 individuals. The female-to-male ratio was 14.5:1. A total of 114 pSS patients died during the study period. The overall survival rate of pSS patients was 99.0{\%}, and the 1-year, 2-year, and 5-year survival rates were 98.7{\%}, 98.1{\%}, and 97.1{\%}, respectively, and the standardized mortality ratio (SMR) was 1.47 (2.14 for males and 1.35 for females). The most common causes of death were respiratory disease (n = 25; 21.9{\%}) followed by circulatory diseases (n = 21; 18.4{\%}), musculoskeletal connective tissue diseases (n = 21; 18.4{\%}), and cancer (n=19; 16.7{\%}). Conclusions The national incidence of pSS in Korea presented in this study was lower in comparison with reports from other countries. However, the mortality rate was significantly higher than the corresponding values in the age- and gender-matched general population. The higher mortality in pSS patients is attributable to respiratory diseases and lung cancer.",
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T1 - Incidence, mortality, and causes of death in physician-diagnosed primary Sjögren's syndrome in Korea

T2 - A nationwide, population-based study

AU - Kim, Hyun Jung

AU - Kim, Kyoung Hoon

AU - Hann, Hoo Jae

AU - Han, Seungjin

AU - Kim, Yuri

AU - Lee, Sang Hyuk

AU - Kim, Dong Sook

AU - Ahn, Hyeong Sik

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N2 - Objectives The objective of this study was to investigate the epidemiological features of primary Sjögren's syndrome (pSS) in Korea at a national level, including the incidence, mortality, and causes of death. Methods We used a national, population-based registry database called the Rare Intractable Disease Registration Program from the Health Insurance Review and Assessment Service to obtain pSS patient data for the period between 2010 and 2014. pSS was diagnosed by a physician based on uniform criteria. We also used data from Statistics Korea to confirm the mortality and causes of death. Results Between 2010 and 2014, the total number of patients newly diagnosed with pSS was 5891, resulting in an annual incidence of 2.34 per 100,000 individuals. The female-to-male ratio was 14.5:1. A total of 114 pSS patients died during the study period. The overall survival rate of pSS patients was 99.0%, and the 1-year, 2-year, and 5-year survival rates were 98.7%, 98.1%, and 97.1%, respectively, and the standardized mortality ratio (SMR) was 1.47 (2.14 for males and 1.35 for females). The most common causes of death were respiratory disease (n = 25; 21.9%) followed by circulatory diseases (n = 21; 18.4%), musculoskeletal connective tissue diseases (n = 21; 18.4%), and cancer (n=19; 16.7%). Conclusions The national incidence of pSS in Korea presented in this study was lower in comparison with reports from other countries. However, the mortality rate was significantly higher than the corresponding values in the age- and gender-matched general population. The higher mortality in pSS patients is attributable to respiratory diseases and lung cancer.

AB - Objectives The objective of this study was to investigate the epidemiological features of primary Sjögren's syndrome (pSS) in Korea at a national level, including the incidence, mortality, and causes of death. Methods We used a national, population-based registry database called the Rare Intractable Disease Registration Program from the Health Insurance Review and Assessment Service to obtain pSS patient data for the period between 2010 and 2014. pSS was diagnosed by a physician based on uniform criteria. We also used data from Statistics Korea to confirm the mortality and causes of death. Results Between 2010 and 2014, the total number of patients newly diagnosed with pSS was 5891, resulting in an annual incidence of 2.34 per 100,000 individuals. The female-to-male ratio was 14.5:1. A total of 114 pSS patients died during the study period. The overall survival rate of pSS patients was 99.0%, and the 1-year, 2-year, and 5-year survival rates were 98.7%, 98.1%, and 97.1%, respectively, and the standardized mortality ratio (SMR) was 1.47 (2.14 for males and 1.35 for females). The most common causes of death were respiratory disease (n = 25; 21.9%) followed by circulatory diseases (n = 21; 18.4%), musculoskeletal connective tissue diseases (n = 21; 18.4%), and cancer (n=19; 16.7%). Conclusions The national incidence of pSS in Korea presented in this study was lower in comparison with reports from other countries. However, the mortality rate was significantly higher than the corresponding values in the age- and gender-matched general population. The higher mortality in pSS patients is attributable to respiratory diseases and lung cancer.

KW - Causes of death

KW - Epidemiology

KW - Mortality

KW - Primary Sjögren's

KW - syndrome

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