Incidence of and risk factors for Alzheimer's disease and mild cognitive impairment in Korean elderly

Jong Bin Bae; You Joung Kim; Ji Won Han; Tae Hui Kim; Joon Hyuk Park; Seok Bum Lee; Jung Jae Lee; Hyun Ghang Jeong; Jeong Lan Kim; Jin Hyeong Jhoo; Jong Chul Yoon; Ki Woong Kim

doi:10.1159/000366555

Incidence of and risk factors for Alzheimer's disease and mild cognitive impairment in Korean elderly

Jong Bin Bae, You Joung Kim, Ji Won Han, Tae Hui Kim, Joon Hyuk Park, Seok Bum Lee, Jung Jae Lee, Hyun Ghang Jeong, Jeong Lan Kim, Jin Hyeong Jhoo, Jong Chul Yoon, Ki Woong Kim

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Background/Aims: Knowledge of incidence rates and risk factors is essential for the development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods: A subpopulation of the Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged ≥65 years from 2 rural and 2 urban districts) was followed up for 3.5 years. The age-specific incidence was estimated and risk factors were identified. Results: The age-standardized incidence of AD and MCI was 7.9 and 28.1 cases per 1,000 person-years, respectively. MCI was associated with a 6-fold increased risk of AD. Depression was a risk factor for AD with MCI. Age, lack of formal education, illiteracy, rural residence, and marital status were associated with the risk of AD. Conclusion: Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD.

Original language	English
Pages (from-to)	105-115
Number of pages	11
Journal	Dementia and Geriatric Cognitive Disorders
Volume	39
DOIs	https://doi.org/10.1159/000366555
Publication status	Published - 2015 Feb 4

Keywords

Alzheimer's disease
Epidemiology
Incidence
Korea
Mild cognitive impairment
Risk factors

ASJC Scopus subject areas

Geriatrics and Gerontology
Cognitive Neuroscience
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000366555

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abstract = "Background/Aims: Knowledge of incidence rates and risk factors is essential for the development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods: A subpopulation of the Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged ≥65 years from 2 rural and 2 urban districts) was followed up for 3.5 years. The age-specific incidence was estimated and risk factors were identified. Results: The age-standardized incidence of AD and MCI was 7.9 and 28.1 cases per 1,000 person-years, respectively. MCI was associated with a 6-fold increased risk of AD. Depression was a risk factor for AD with MCI. Age, lack of formal education, illiteracy, rural residence, and marital status were associated with the risk of AD. Conclusion: Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD.",

keywords = "Alzheimer's disease, Epidemiology, Incidence, Korea, Mild cognitive impairment, Risk factors",

author = "Bae, {Jong Bin} and Kim, {You Joung} and Han, {Ji Won} and Kim, {Tae Hui} and Park, {Joon Hyuk} and Lee, {Seok Bum} and Lee, {Jung Jae} and Jeong, {Hyun Ghang} and Kim, {Jeong Lan} and Jhoo, {Jin Hyeong} and Yoon, {Jong Chul} and Kim, {Ki Woong}",

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doi = "10.1159/000366555",

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T1 - Incidence of and risk factors for Alzheimer's disease and mild cognitive impairment in Korean elderly

AU - Bae, Jong Bin

AU - Kim, You Joung

AU - Han, Ji Won

AU - Kim, Tae Hui

AU - Park, Joon Hyuk

AU - Lee, Seok Bum

AU - Lee, Jung Jae

AU - Jeong, Hyun Ghang

AU - Kim, Jeong Lan

AU - Jhoo, Jin Hyeong

AU - Yoon, Jong Chul

AU - Kim, Ki Woong

PY - 2015/2/4

Y1 - 2015/2/4

N2 - Background/Aims: Knowledge of incidence rates and risk factors is essential for the development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods: A subpopulation of the Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged ≥65 years from 2 rural and 2 urban districts) was followed up for 3.5 years. The age-specific incidence was estimated and risk factors were identified. Results: The age-standardized incidence of AD and MCI was 7.9 and 28.1 cases per 1,000 person-years, respectively. MCI was associated with a 6-fold increased risk of AD. Depression was a risk factor for AD with MCI. Age, lack of formal education, illiteracy, rural residence, and marital status were associated with the risk of AD. Conclusion: Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD.

AB - Background/Aims: Knowledge of incidence rates and risk factors is essential for the development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods: A subpopulation of the Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged ≥65 years from 2 rural and 2 urban districts) was followed up for 3.5 years. The age-specific incidence was estimated and risk factors were identified. Results: The age-standardized incidence of AD and MCI was 7.9 and 28.1 cases per 1,000 person-years, respectively. MCI was associated with a 6-fold increased risk of AD. Depression was a risk factor for AD with MCI. Age, lack of formal education, illiteracy, rural residence, and marital status were associated with the risk of AD. Conclusion: Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD.

KW - Alzheimer's disease

KW - Epidemiology

KW - Incidence

KW - Korea

KW - Mild cognitive impairment

KW - Risk factors

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Incidence of and risk factors for Alzheimer's disease and mild cognitive impairment in Korean elderly

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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