Incidence of and risk factors for Alzheimer's disease and mild cognitive impairment in Korean elderly

Jong Bin Bae, You Joung Kim, Ji Won Han, Tae Hui Kim, Joon Hyuk Park, Seok Bum Lee, Jung Jae Lee, Hyun Ghang Jeong, Jeong Lan Kim, Jin Hyeong Jhoo, Jong Chul Yoon, Ki Woong Kim

    Research output: Contribution to journalArticlepeer-review

    57 Citations (Scopus)

    Abstract

    Background/Aims: Knowledge of incidence rates and risk factors is essential for the development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Methods: A subpopulation of the Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged ≥65 years from 2 rural and 2 urban districts) was followed up for 3.5 years. The age-specific incidence was estimated and risk factors were identified. Results: The age-standardized incidence of AD and MCI was 7.9 and 28.1 cases per 1,000 person-years, respectively. MCI was associated with a 6-fold increased risk of AD. Depression was a risk factor for AD with MCI. Age, lack of formal education, illiteracy, rural residence, and marital status were associated with the risk of AD. Conclusion: Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD.

    Original languageEnglish
    Pages (from-to)105-115
    Number of pages11
    JournalDementia and Geriatric Cognitive Disorders
    Volume39
    DOIs
    Publication statusPublished - 2015 Feb 4

    Keywords

    • Alzheimer's disease
    • Epidemiology
    • Incidence
    • Korea
    • Mild cognitive impairment
    • Risk factors

    ASJC Scopus subject areas

    • Geriatrics and Gerontology
    • Cognitive Neuroscience
    • Psychiatry and Mental health

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