Incidence of Post-transplantation Diabetes Mellitus Within 1 Year After Kidney Transplantation and Related Factors in Korean Cohort Study

Jin Hyuk Paek, Seong Sik Kang, Woo Yeong Park, Kyubok Jin, Sung Bae Park, Seungyeup Han, Chan Duck Kim, Han Ro, Sik Lee, Cheol Woong Jung, Jae Berm Park, Kyu Ha Huh, Jaeseok Yang, Curie Ahn

Research output: Contribution to journalArticle

Abstract

Background: Post-transplantation diabetes mellitus (PTDM) is associated with a higher risk of mortality and graft loss. The reported incidence of PTDM after kidney transplantation (KT) varies from 10% to 74% and varies by country and ethnicity. There are few reports of nationwide cohort studies on PTDM incidence and related factors in Korea. The purpose of this study was to evaluate incidence of PTDM and related factors within 1 year after KT in Korea. Methods: The KoreaN cohort study for Outcome in patients With Kidney Transplantation (KNOW-KT) enrolled 1080 recipients from July 2012 to August 2016. This study included 723 recipients, excluding 273 patients with pretransplant DM and 84 patients who were lost from follow-up within 1 year after KT. Results: Among 723 recipients, 85 (11.8%) recipients were diagnosed and treated with PTDM. Recipient age, HLA mismatches, hemoglobin A1c (HbA1c), waist-hip ratio (WHR), and use of prednisolone were significantly higher in PTDM group than the nondiabetic group. In the multivariable logistic regression analysis, independent risk factors for PTDM were older recipient age, higher WHR, and HbA1c before KT. Conclusion: The incidence of PTDM was 11.8% in a nationwide Korean cohort study. The factors related to the development of PTDM within 1 year after KT were older recipient age and higher WHR, and HbA1c levels before KT. In recipients with high WHR, it is important to control pretransplant abdominal obesity to prevent PTDM after KT.

Original languageEnglish
JournalTransplantation Proceedings
DOIs
Publication statusAccepted/In press - 2019 Jan 1

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Kidney Transplantation
Diabetes Mellitus
Cohort Studies
Transplantation
Incidence
Waist-Hip Ratio
Hemoglobins
Korea
Abdominal Obesity
Prednisolone
Logistic Models
Regression Analysis
Transplants
Mortality

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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Incidence of Post-transplantation Diabetes Mellitus Within 1 Year After Kidney Transplantation and Related Factors in Korean Cohort Study. / Paek, Jin Hyuk; Kang, Seong Sik; Park, Woo Yeong; Jin, Kyubok; Park, Sung Bae; Han, Seungyeup; Kim, Chan Duck; Ro, Han; Lee, Sik; Jung, Cheol Woong; Park, Jae Berm; Huh, Kyu Ha; Yang, Jaeseok; Ahn, Curie.

In: Transplantation Proceedings, 01.01.2019.

Research output: Contribution to journalArticle

Paek, Jin Hyuk ; Kang, Seong Sik ; Park, Woo Yeong ; Jin, Kyubok ; Park, Sung Bae ; Han, Seungyeup ; Kim, Chan Duck ; Ro, Han ; Lee, Sik ; Jung, Cheol Woong ; Park, Jae Berm ; Huh, Kyu Ha ; Yang, Jaeseok ; Ahn, Curie. / Incidence of Post-transplantation Diabetes Mellitus Within 1 Year After Kidney Transplantation and Related Factors in Korean Cohort Study. In: Transplantation Proceedings. 2019.
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abstract = "Background: Post-transplantation diabetes mellitus (PTDM) is associated with a higher risk of mortality and graft loss. The reported incidence of PTDM after kidney transplantation (KT) varies from 10{\%} to 74{\%} and varies by country and ethnicity. There are few reports of nationwide cohort studies on PTDM incidence and related factors in Korea. The purpose of this study was to evaluate incidence of PTDM and related factors within 1 year after KT in Korea. Methods: The KoreaN cohort study for Outcome in patients With Kidney Transplantation (KNOW-KT) enrolled 1080 recipients from July 2012 to August 2016. This study included 723 recipients, excluding 273 patients with pretransplant DM and 84 patients who were lost from follow-up within 1 year after KT. Results: Among 723 recipients, 85 (11.8{\%}) recipients were diagnosed and treated with PTDM. Recipient age, HLA mismatches, hemoglobin A1c (HbA1c), waist-hip ratio (WHR), and use of prednisolone were significantly higher in PTDM group than the nondiabetic group. In the multivariable logistic regression analysis, independent risk factors for PTDM were older recipient age, higher WHR, and HbA1c before KT. Conclusion: The incidence of PTDM was 11.8{\%} in a nationwide Korean cohort study. The factors related to the development of PTDM within 1 year after KT were older recipient age and higher WHR, and HbA1c levels before KT. In recipients with high WHR, it is important to control pretransplant abdominal obesity to prevent PTDM after KT.",
author = "Paek, {Jin Hyuk} and Kang, {Seong Sik} and Park, {Woo Yeong} and Kyubok Jin and Park, {Sung Bae} and Seungyeup Han and Kim, {Chan Duck} and Han Ro and Sik Lee and Jung, {Cheol Woong} and Park, {Jae Berm} and Huh, {Kyu Ha} and Jaeseok Yang and Curie Ahn",
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T1 - Incidence of Post-transplantation Diabetes Mellitus Within 1 Year After Kidney Transplantation and Related Factors in Korean Cohort Study

AU - Paek, Jin Hyuk

AU - Kang, Seong Sik

AU - Park, Woo Yeong

AU - Jin, Kyubok

AU - Park, Sung Bae

AU - Han, Seungyeup

AU - Kim, Chan Duck

AU - Ro, Han

AU - Lee, Sik

AU - Jung, Cheol Woong

AU - Park, Jae Berm

AU - Huh, Kyu Ha

AU - Yang, Jaeseok

AU - Ahn, Curie

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Post-transplantation diabetes mellitus (PTDM) is associated with a higher risk of mortality and graft loss. The reported incidence of PTDM after kidney transplantation (KT) varies from 10% to 74% and varies by country and ethnicity. There are few reports of nationwide cohort studies on PTDM incidence and related factors in Korea. The purpose of this study was to evaluate incidence of PTDM and related factors within 1 year after KT in Korea. Methods: The KoreaN cohort study for Outcome in patients With Kidney Transplantation (KNOW-KT) enrolled 1080 recipients from July 2012 to August 2016. This study included 723 recipients, excluding 273 patients with pretransplant DM and 84 patients who were lost from follow-up within 1 year after KT. Results: Among 723 recipients, 85 (11.8%) recipients were diagnosed and treated with PTDM. Recipient age, HLA mismatches, hemoglobin A1c (HbA1c), waist-hip ratio (WHR), and use of prednisolone were significantly higher in PTDM group than the nondiabetic group. In the multivariable logistic regression analysis, independent risk factors for PTDM were older recipient age, higher WHR, and HbA1c before KT. Conclusion: The incidence of PTDM was 11.8% in a nationwide Korean cohort study. The factors related to the development of PTDM within 1 year after KT were older recipient age and higher WHR, and HbA1c levels before KT. In recipients with high WHR, it is important to control pretransplant abdominal obesity to prevent PTDM after KT.

AB - Background: Post-transplantation diabetes mellitus (PTDM) is associated with a higher risk of mortality and graft loss. The reported incidence of PTDM after kidney transplantation (KT) varies from 10% to 74% and varies by country and ethnicity. There are few reports of nationwide cohort studies on PTDM incidence and related factors in Korea. The purpose of this study was to evaluate incidence of PTDM and related factors within 1 year after KT in Korea. Methods: The KoreaN cohort study for Outcome in patients With Kidney Transplantation (KNOW-KT) enrolled 1080 recipients from July 2012 to August 2016. This study included 723 recipients, excluding 273 patients with pretransplant DM and 84 patients who were lost from follow-up within 1 year after KT. Results: Among 723 recipients, 85 (11.8%) recipients were diagnosed and treated with PTDM. Recipient age, HLA mismatches, hemoglobin A1c (HbA1c), waist-hip ratio (WHR), and use of prednisolone were significantly higher in PTDM group than the nondiabetic group. In the multivariable logistic regression analysis, independent risk factors for PTDM were older recipient age, higher WHR, and HbA1c before KT. Conclusion: The incidence of PTDM was 11.8% in a nationwide Korean cohort study. The factors related to the development of PTDM within 1 year after KT were older recipient age and higher WHR, and HbA1c levels before KT. In recipients with high WHR, it is important to control pretransplant abdominal obesity to prevent PTDM after KT.

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U2 - 10.1016/j.transproceed.2019.02.054

DO - 10.1016/j.transproceed.2019.02.054

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JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

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