Incidence of prostate cancer according to metabolic health status: A nationwide cohort study

Jong Wook Kim, Sun Tae Ahn, Mi-Mi Oh, Du Geon Moon, Kyungdo Han, Hong Seok Park

Research output: Contribution to journalArticle

Abstract

Background: We assessed the association between metabolic health status and incidence of prostate cancer using the National Health Check-ups (NHC) database of Korea. Methods: A total of 11,771,252 men who participated in the NHC between 2009 and 2012 and 56,552 men who were newly diagnosed with prostate cancer were analyzed. Normal-weight and obesity were defined as body mass index (BMI) < 25 kg/m 2 and ≥25 kg/m 2 , respectively. Metabolic obesity was defined as the presence ≥3 components of the metabolic syndrome. Participants were stratified into 4 groups: metabolically healthy, normal-weight; metabolically obese, normal-weight (MONW); metabolically healthy, obese (MHO); and metabolically obese, obese. Multivariate Cox regression analysis was performed to examine the relationship between metabolic health status and incidence of prostate cancer. Results: During a mean 5.4 ± 1.1 years of follow-up, 56,552 patients were registered with a diagnosis of prostate cancer. When analyzed according to metabolic health status classification, the multivariable-adjusted hazard ratio (HR) was 1.143 for the MONW group, 1.097 for the MHO group, showing the HR for the MONW group was higher than that for the MHO group. As the number of metabolic syndrome components increased, HR increased significantly. When stratified based on BMI, metabolically obese patients showed significantly higher HR than metabolically healthy patients in all BMI groups. Conclusion: This population-based nationwide study revealed an association between metabolic health status and the incidence of prostate cancer, and the risk increased according to the number of components of the metabolic syndrome.

Original languageEnglish
Article numbere49
JournalJournal of Korean medical science
Volume34
Issue number6
DOIs
Publication statusPublished - 2019 Feb 18

Fingerprint

Health Status
Prostatic Neoplasms
Cohort Studies
Weights and Measures
Incidence
Body Mass Index
Obesity
Health
Korea
Regression Analysis
Databases
Population

Keywords

  • Metabolic health
  • Metabolically healthy obese
  • Metabolically obese normal weight
  • Obesity
  • Prostate cancer

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Incidence of prostate cancer according to metabolic health status : A nationwide cohort study. / Kim, Jong Wook; Ahn, Sun Tae; Oh, Mi-Mi; Moon, Du Geon; Han, Kyungdo; Park, Hong Seok.

In: Journal of Korean medical science, Vol. 34, No. 6, e49, 18.02.2019.

Research output: Contribution to journalArticle

@article{546913a1c9ec40adaf01d08e1ce3b386,
title = "Incidence of prostate cancer according to metabolic health status: A nationwide cohort study",
abstract = "Background: We assessed the association between metabolic health status and incidence of prostate cancer using the National Health Check-ups (NHC) database of Korea. Methods: A total of 11,771,252 men who participated in the NHC between 2009 and 2012 and 56,552 men who were newly diagnosed with prostate cancer were analyzed. Normal-weight and obesity were defined as body mass index (BMI) < 25 kg/m 2 and ≥25 kg/m 2 , respectively. Metabolic obesity was defined as the presence ≥3 components of the metabolic syndrome. Participants were stratified into 4 groups: metabolically healthy, normal-weight; metabolically obese, normal-weight (MONW); metabolically healthy, obese (MHO); and metabolically obese, obese. Multivariate Cox regression analysis was performed to examine the relationship between metabolic health status and incidence of prostate cancer. Results: During a mean 5.4 ± 1.1 years of follow-up, 56,552 patients were registered with a diagnosis of prostate cancer. When analyzed according to metabolic health status classification, the multivariable-adjusted hazard ratio (HR) was 1.143 for the MONW group, 1.097 for the MHO group, showing the HR for the MONW group was higher than that for the MHO group. As the number of metabolic syndrome components increased, HR increased significantly. When stratified based on BMI, metabolically obese patients showed significantly higher HR than metabolically healthy patients in all BMI groups. Conclusion: This population-based nationwide study revealed an association between metabolic health status and the incidence of prostate cancer, and the risk increased according to the number of components of the metabolic syndrome.",
keywords = "Metabolic health, Metabolically healthy obese, Metabolically obese normal weight, Obesity, Prostate cancer",
author = "Kim, {Jong Wook} and Ahn, {Sun Tae} and Mi-Mi Oh and Moon, {Du Geon} and Kyungdo Han and Park, {Hong Seok}",
year = "2019",
month = "2",
day = "18",
doi = "10.3346/jkms.2019.34.e49",
language = "English",
volume = "34",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "6",

}

TY - JOUR

T1 - Incidence of prostate cancer according to metabolic health status

T2 - A nationwide cohort study

AU - Kim, Jong Wook

AU - Ahn, Sun Tae

AU - Oh, Mi-Mi

AU - Moon, Du Geon

AU - Han, Kyungdo

AU - Park, Hong Seok

PY - 2019/2/18

Y1 - 2019/2/18

N2 - Background: We assessed the association between metabolic health status and incidence of prostate cancer using the National Health Check-ups (NHC) database of Korea. Methods: A total of 11,771,252 men who participated in the NHC between 2009 and 2012 and 56,552 men who were newly diagnosed with prostate cancer were analyzed. Normal-weight and obesity were defined as body mass index (BMI) < 25 kg/m 2 and ≥25 kg/m 2 , respectively. Metabolic obesity was defined as the presence ≥3 components of the metabolic syndrome. Participants were stratified into 4 groups: metabolically healthy, normal-weight; metabolically obese, normal-weight (MONW); metabolically healthy, obese (MHO); and metabolically obese, obese. Multivariate Cox regression analysis was performed to examine the relationship between metabolic health status and incidence of prostate cancer. Results: During a mean 5.4 ± 1.1 years of follow-up, 56,552 patients were registered with a diagnosis of prostate cancer. When analyzed according to metabolic health status classification, the multivariable-adjusted hazard ratio (HR) was 1.143 for the MONW group, 1.097 for the MHO group, showing the HR for the MONW group was higher than that for the MHO group. As the number of metabolic syndrome components increased, HR increased significantly. When stratified based on BMI, metabolically obese patients showed significantly higher HR than metabolically healthy patients in all BMI groups. Conclusion: This population-based nationwide study revealed an association between metabolic health status and the incidence of prostate cancer, and the risk increased according to the number of components of the metabolic syndrome.

AB - Background: We assessed the association between metabolic health status and incidence of prostate cancer using the National Health Check-ups (NHC) database of Korea. Methods: A total of 11,771,252 men who participated in the NHC between 2009 and 2012 and 56,552 men who were newly diagnosed with prostate cancer were analyzed. Normal-weight and obesity were defined as body mass index (BMI) < 25 kg/m 2 and ≥25 kg/m 2 , respectively. Metabolic obesity was defined as the presence ≥3 components of the metabolic syndrome. Participants were stratified into 4 groups: metabolically healthy, normal-weight; metabolically obese, normal-weight (MONW); metabolically healthy, obese (MHO); and metabolically obese, obese. Multivariate Cox regression analysis was performed to examine the relationship between metabolic health status and incidence of prostate cancer. Results: During a mean 5.4 ± 1.1 years of follow-up, 56,552 patients were registered with a diagnosis of prostate cancer. When analyzed according to metabolic health status classification, the multivariable-adjusted hazard ratio (HR) was 1.143 for the MONW group, 1.097 for the MHO group, showing the HR for the MONW group was higher than that for the MHO group. As the number of metabolic syndrome components increased, HR increased significantly. When stratified based on BMI, metabolically obese patients showed significantly higher HR than metabolically healthy patients in all BMI groups. Conclusion: This population-based nationwide study revealed an association between metabolic health status and the incidence of prostate cancer, and the risk increased according to the number of components of the metabolic syndrome.

KW - Metabolic health

KW - Metabolically healthy obese

KW - Metabolically obese normal weight

KW - Obesity

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=85061715715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061715715&partnerID=8YFLogxK

U2 - 10.3346/jkms.2019.34.e49

DO - 10.3346/jkms.2019.34.e49

M3 - Article

C2 - 30787682

AN - SCOPUS:85061715715

VL - 34

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 6

M1 - e49

ER -