Incidence of Thromboembolism in Patients Who Discontinued Warfarin within 2 Months after Atrial Fibrillation Ablation

Hyung Don Kook, Dae In Lee, Jun Hyuk Kang, Young Hoon Kim

Research output: Contribution to journalArticle

Abstract

It is not yet determined when oral anticoagulation (OAC) can be discontinued after atrial fibrillation (AF) ablation. This study was to evaluate the incidence of thromboembolism (TE) in patients who discontinued warfarin within 2 months after Catheter ablation (CA) of AF. Methods: The study population consisted of 179 patients who had undergone CA. Sixty four patients discontinued OAC within 2 months after CA (Off-OAC group) and 115 remained on OAC at least more than 2 months (On-OAC group). The primary endpoint was episode of TE. Results: Compared to Off-OAC group, On-OAC group had greater number of stroke history prior to CA (n= 14, 12.2% vs. n=1, 1.6%, p<0.05). Other characteristics including CHADS2 score between two groups were similar. During mean 33 months of follow-up, none in Off-OAC group but 4 (3.5%) patients of On-OAC group had TE without significance (p = 0.298). Univariate analysis revealed that age, sex, AF duration, follow-up duration, stroke history and CHADS2 score were related to development of TE. On multivariate analysis, AF duration (OR 1.021, CI: 1.002 - 1.041, p=0.032) was the only independent predictor of TE. Conclusion: OAC after AF ablation needs to be individualized with AF duration. The incidence of TE in patients who discontinued warfarin within 2 months was not different from those who continued warfarin for longer than 2 months.

Original languageEnglish
Number of pages1
JournalJournal of Arrhythmia
Volume27
Issue number4
DOIs
Publication statusPublished - 2011 Jan 1

Fingerprint

Thromboembolism
Warfarin
Atrial Fibrillation
Catheter Ablation
Incidence
Stroke
Multivariate Analysis
Population

Keywords

  • atrial fibrillation
  • radiofrequency Catheter ablation
  • warfarin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Incidence of Thromboembolism in Patients Who Discontinued Warfarin within 2 Months after Atrial Fibrillation Ablation. / Kook, Hyung Don; Lee, Dae In; Kang, Jun Hyuk; Kim, Young Hoon.

In: Journal of Arrhythmia, Vol. 27, No. 4, 01.01.2011.

Research output: Contribution to journalArticle

@article{fc557e32452f43a6b6475a5d188c9a89,
title = "Incidence of Thromboembolism in Patients Who Discontinued Warfarin within 2 Months after Atrial Fibrillation Ablation",
abstract = "It is not yet determined when oral anticoagulation (OAC) can be discontinued after atrial fibrillation (AF) ablation. This study was to evaluate the incidence of thromboembolism (TE) in patients who discontinued warfarin within 2 months after Catheter ablation (CA) of AF. Methods: The study population consisted of 179 patients who had undergone CA. Sixty four patients discontinued OAC within 2 months after CA (Off-OAC group) and 115 remained on OAC at least more than 2 months (On-OAC group). The primary endpoint was episode of TE. Results: Compared to Off-OAC group, On-OAC group had greater number of stroke history prior to CA (n= 14, 12.2{\%} vs. n=1, 1.6{\%}, p<0.05). Other characteristics including CHADS2 score between two groups were similar. During mean 33 months of follow-up, none in Off-OAC group but 4 (3.5{\%}) patients of On-OAC group had TE without significance (p = 0.298). Univariate analysis revealed that age, sex, AF duration, follow-up duration, stroke history and CHADS2 score were related to development of TE. On multivariate analysis, AF duration (OR 1.021, CI: 1.002 - 1.041, p=0.032) was the only independent predictor of TE. Conclusion: OAC after AF ablation needs to be individualized with AF duration. The incidence of TE in patients who discontinued warfarin within 2 months was not different from those who continued warfarin for longer than 2 months.",
keywords = "atrial fibrillation, radiofrequency Catheter ablation, warfarin",
author = "Kook, {Hyung Don} and Lee, {Dae In} and Kang, {Jun Hyuk} and Kim, {Young Hoon}",
year = "2011",
month = "1",
day = "1",
doi = "10.4020/jhrs.27.OP21_2",
language = "English",
volume = "27",
journal = "Journal of Arrhythmia",
issn = "1880-4276",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - Incidence of Thromboembolism in Patients Who Discontinued Warfarin within 2 Months after Atrial Fibrillation Ablation

AU - Kook, Hyung Don

AU - Lee, Dae In

AU - Kang, Jun Hyuk

AU - Kim, Young Hoon

PY - 2011/1/1

Y1 - 2011/1/1

N2 - It is not yet determined when oral anticoagulation (OAC) can be discontinued after atrial fibrillation (AF) ablation. This study was to evaluate the incidence of thromboembolism (TE) in patients who discontinued warfarin within 2 months after Catheter ablation (CA) of AF. Methods: The study population consisted of 179 patients who had undergone CA. Sixty four patients discontinued OAC within 2 months after CA (Off-OAC group) and 115 remained on OAC at least more than 2 months (On-OAC group). The primary endpoint was episode of TE. Results: Compared to Off-OAC group, On-OAC group had greater number of stroke history prior to CA (n= 14, 12.2% vs. n=1, 1.6%, p<0.05). Other characteristics including CHADS2 score between two groups were similar. During mean 33 months of follow-up, none in Off-OAC group but 4 (3.5%) patients of On-OAC group had TE without significance (p = 0.298). Univariate analysis revealed that age, sex, AF duration, follow-up duration, stroke history and CHADS2 score were related to development of TE. On multivariate analysis, AF duration (OR 1.021, CI: 1.002 - 1.041, p=0.032) was the only independent predictor of TE. Conclusion: OAC after AF ablation needs to be individualized with AF duration. The incidence of TE in patients who discontinued warfarin within 2 months was not different from those who continued warfarin for longer than 2 months.

AB - It is not yet determined when oral anticoagulation (OAC) can be discontinued after atrial fibrillation (AF) ablation. This study was to evaluate the incidence of thromboembolism (TE) in patients who discontinued warfarin within 2 months after Catheter ablation (CA) of AF. Methods: The study population consisted of 179 patients who had undergone CA. Sixty four patients discontinued OAC within 2 months after CA (Off-OAC group) and 115 remained on OAC at least more than 2 months (On-OAC group). The primary endpoint was episode of TE. Results: Compared to Off-OAC group, On-OAC group had greater number of stroke history prior to CA (n= 14, 12.2% vs. n=1, 1.6%, p<0.05). Other characteristics including CHADS2 score between two groups were similar. During mean 33 months of follow-up, none in Off-OAC group but 4 (3.5%) patients of On-OAC group had TE without significance (p = 0.298). Univariate analysis revealed that age, sex, AF duration, follow-up duration, stroke history and CHADS2 score were related to development of TE. On multivariate analysis, AF duration (OR 1.021, CI: 1.002 - 1.041, p=0.032) was the only independent predictor of TE. Conclusion: OAC after AF ablation needs to be individualized with AF duration. The incidence of TE in patients who discontinued warfarin within 2 months was not different from those who continued warfarin for longer than 2 months.

KW - atrial fibrillation

KW - radiofrequency Catheter ablation

KW - warfarin

UR - http://www.scopus.com/inward/record.url?scp=85009547662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009547662&partnerID=8YFLogxK

U2 - 10.4020/jhrs.27.OP21_2

DO - 10.4020/jhrs.27.OP21_2

M3 - Article

VL - 27

JO - Journal of Arrhythmia

JF - Journal of Arrhythmia

SN - 1880-4276

IS - 4

ER -