Abstract
It is not yet determined when oral anticoagulation (OAC) can be discontinued after atrial fibrillation (AF) ablation. This study was to evaluate the incidence of thromboembolism (TE) in patients who discontinued warfarin within 2 months after Catheter ablation (CA) of AF. Methods: The study population consisted of 179 patients who had undergone CA. Sixty four patients discontinued OAC within 2 months after CA (Off-OAC group) and 115 remained on OAC at least more than 2 months (On-OAC group). The primary endpoint was episode of TE. Results: Compared to Off-OAC group, On-OAC group had greater number of stroke history prior to CA (n= 14, 12.2% vs. n=1, 1.6%, p<0.05). Other characteristics including CHADS2 score between two groups were similar. During mean 33 months of follow-up, none in Off-OAC group but 4 (3.5%) patients of On-OAC group had TE without significance (p = 0.298). Univariate analysis revealed that age, sex, AF duration, follow-up duration, stroke history and CHADS2 score were related to development of TE. On multivariate analysis, AF duration (OR 1.021, CI: 1.002 - 1.041, p=0.032) was the only independent predictor of TE. Conclusion: OAC after AF ablation needs to be individualized with AF duration. The incidence of TE in patients who discontinued warfarin within 2 months was not different from those who continued warfarin for longer than 2 months.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Journal | Journal of Arrhythmia |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2011 Jan 1 |
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Keywords
- atrial fibrillation
- radiofrequency Catheter ablation
- warfarin
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Incidence of Thromboembolism in Patients Who Discontinued Warfarin within 2 Months after Atrial Fibrillation Ablation. / Kook, Hyung Don; Lee, Dae In; Kang, Jun Hyuk; Kim, Young Hoon.
In: Journal of Arrhythmia, Vol. 27, No. 4, 01.01.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Incidence of Thromboembolism in Patients Who Discontinued Warfarin within 2 Months after Atrial Fibrillation Ablation
AU - Kook, Hyung Don
AU - Lee, Dae In
AU - Kang, Jun Hyuk
AU - Kim, Young Hoon
PY - 2011/1/1
Y1 - 2011/1/1
N2 - It is not yet determined when oral anticoagulation (OAC) can be discontinued after atrial fibrillation (AF) ablation. This study was to evaluate the incidence of thromboembolism (TE) in patients who discontinued warfarin within 2 months after Catheter ablation (CA) of AF. Methods: The study population consisted of 179 patients who had undergone CA. Sixty four patients discontinued OAC within 2 months after CA (Off-OAC group) and 115 remained on OAC at least more than 2 months (On-OAC group). The primary endpoint was episode of TE. Results: Compared to Off-OAC group, On-OAC group had greater number of stroke history prior to CA (n= 14, 12.2% vs. n=1, 1.6%, p<0.05). Other characteristics including CHADS2 score between two groups were similar. During mean 33 months of follow-up, none in Off-OAC group but 4 (3.5%) patients of On-OAC group had TE without significance (p = 0.298). Univariate analysis revealed that age, sex, AF duration, follow-up duration, stroke history and CHADS2 score were related to development of TE. On multivariate analysis, AF duration (OR 1.021, CI: 1.002 - 1.041, p=0.032) was the only independent predictor of TE. Conclusion: OAC after AF ablation needs to be individualized with AF duration. The incidence of TE in patients who discontinued warfarin within 2 months was not different from those who continued warfarin for longer than 2 months.
AB - It is not yet determined when oral anticoagulation (OAC) can be discontinued after atrial fibrillation (AF) ablation. This study was to evaluate the incidence of thromboembolism (TE) in patients who discontinued warfarin within 2 months after Catheter ablation (CA) of AF. Methods: The study population consisted of 179 patients who had undergone CA. Sixty four patients discontinued OAC within 2 months after CA (Off-OAC group) and 115 remained on OAC at least more than 2 months (On-OAC group). The primary endpoint was episode of TE. Results: Compared to Off-OAC group, On-OAC group had greater number of stroke history prior to CA (n= 14, 12.2% vs. n=1, 1.6%, p<0.05). Other characteristics including CHADS2 score between two groups were similar. During mean 33 months of follow-up, none in Off-OAC group but 4 (3.5%) patients of On-OAC group had TE without significance (p = 0.298). Univariate analysis revealed that age, sex, AF duration, follow-up duration, stroke history and CHADS2 score were related to development of TE. On multivariate analysis, AF duration (OR 1.021, CI: 1.002 - 1.041, p=0.032) was the only independent predictor of TE. Conclusion: OAC after AF ablation needs to be individualized with AF duration. The incidence of TE in patients who discontinued warfarin within 2 months was not different from those who continued warfarin for longer than 2 months.
KW - atrial fibrillation
KW - radiofrequency Catheter ablation
KW - warfarin
UR - http://www.scopus.com/inward/record.url?scp=85009547662&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009547662&partnerID=8YFLogxK
U2 - 10.4020/jhrs.27.OP21_2
DO - 10.4020/jhrs.27.OP21_2
M3 - Article
VL - 27
JO - Journal of Arrhythmia
JF - Journal of Arrhythmia
SN - 1880-4276
IS - 4
ER -