Incidence, prevalence, mortality and causes of death in Takayasu Arteritis in Korea – A nationwide, population-based study

Sang Jun Park, Hyun Jung Kim, Hojong Park, Hoo Jae Hann, Kyoung Hoon Kim, Seungjin Han, Yuri Kim, Hyeong Sik Ahn

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background Studies investigating the epidemiology and mortality of Takayasu Arteritis (TA) are scarce. The objective of this study was to provide information regarding the epidemiology of TA, such as the incidence, prevalence, survival and cause of death in Korea. Methods We used a national, population-based database maintained by the Rare Intractable Disease registration program and the Health Insurance Review and Assessment Service, which includes information on all TA patients, diagnosed based on uniform criteria. We also used data from Statistics Korea linked with RID database to confirm survival and cause of death. We analyzed data for the period 2008–2012. Results During study period, there were 612 new patients with TA, with a female-to-male ratio of 4.3:1. The annual mean incidence was 0.24 per 105 people, and the prevalence was 2.82 per 105 people in 2012. The average annual mortality rate was 0.02 per 105 people, and the standardized mortality ratio was 3.1 per 105 people. The overall survival of patients with TA was 96.6%, which was significantly lower than that in the general population. Cardiovascular disease was the most common cause of death, accounting for 29 of the 64 deaths (45.3%), followed by neoplasms in 9 patients (14.1%). Conclusions The incidence and prevalence presented in this study are the highest ever reported. The survival of patients with TA was significantly lower than that of the general population, and the main cause of death was cardiovascular disease. This study reflects the need for greater awareness of TA, especially in Asian countries.

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalInternational Journal of Cardiology
Volume235
DOIs
Publication statusPublished - 2017 May 15

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Takayasu Arteritis
Korea
Cause of Death
Mortality
Incidence
Population
Survival
Epidemiology
Cardiovascular Diseases
Databases
Health Insurance
Rare Diseases

Keywords

  • Epidemiology
  • Incidence
  • Mortality
  • Takayasu arteritis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Incidence, prevalence, mortality and causes of death in Takayasu Arteritis in Korea – A nationwide, population-based study. / Park, Sang Jun; Kim, Hyun Jung; Park, Hojong; Hann, Hoo Jae; Kim, Kyoung Hoon; Han, Seungjin; Kim, Yuri; Ahn, Hyeong Sik.

In: International Journal of Cardiology, Vol. 235, 15.05.2017, p. 100-104.

Research output: Contribution to journalArticle

Park, Sang Jun ; Kim, Hyun Jung ; Park, Hojong ; Hann, Hoo Jae ; Kim, Kyoung Hoon ; Han, Seungjin ; Kim, Yuri ; Ahn, Hyeong Sik. / Incidence, prevalence, mortality and causes of death in Takayasu Arteritis in Korea – A nationwide, population-based study. In: International Journal of Cardiology. 2017 ; Vol. 235. pp. 100-104.
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AU - Ahn, Hyeong Sik

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AB - Background Studies investigating the epidemiology and mortality of Takayasu Arteritis (TA) are scarce. The objective of this study was to provide information regarding the epidemiology of TA, such as the incidence, prevalence, survival and cause of death in Korea. Methods We used a national, population-based database maintained by the Rare Intractable Disease registration program and the Health Insurance Review and Assessment Service, which includes information on all TA patients, diagnosed based on uniform criteria. We also used data from Statistics Korea linked with RID database to confirm survival and cause of death. We analyzed data for the period 2008–2012. Results During study period, there were 612 new patients with TA, with a female-to-male ratio of 4.3:1. The annual mean incidence was 0.24 per 105 people, and the prevalence was 2.82 per 105 people in 2012. The average annual mortality rate was 0.02 per 105 people, and the standardized mortality ratio was 3.1 per 105 people. The overall survival of patients with TA was 96.6%, which was significantly lower than that in the general population. Cardiovascular disease was the most common cause of death, accounting for 29 of the 64 deaths (45.3%), followed by neoplasms in 9 patients (14.1%). Conclusions The incidence and prevalence presented in this study are the highest ever reported. The survival of patients with TA was significantly lower than that of the general population, and the main cause of death was cardiovascular disease. This study reflects the need for greater awareness of TA, especially in Asian countries.

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