Incomplete clinical manifestation as a risk factor for coronary artery abnormalities in Kawasaki disease

A meta-analysis

Kee Soo Ha, Giyoung Jang, Jung Hwa Lee, Kwang Chul Lee, Young Sook Hong, Chang Sung Son, Joowon Lee

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Incomplete Kawasaki disease (KD) comprises a large proportion of the total number of cases. Although it has the potential of delaying diagnosis, it is not conclusive whether an incomplete presentation is a risk factor for coronary artery abnormalities (CAAs). We performed a meta-analysis to establish the risk of CAA in 20 studies including 4,504 cases and 32,519 controls, and the risk of giant aneurysm in two studies including 5,390 cases and 37,648 controls. The pooled results indicated that incomplete KD was associated with an increased risk of CAA [odds ratio (OR) = 1.447, 95 % confidence interval (CI) = 1.158-1.808, p = 0.001]. Subgroup analyses demonstrated higher associations in patients younger than 12 months (OR = 2.023, 95 % CI = 1.252-3.271, p = 0.004), Asians and Indians (OR = 1.57, 95 % CI = 1.234-1.999, p < 0.001 and OR = 7.088, 95 % CI = 1.640-30.631, p = 0.009, respectively). Subgroup analysis according to the period of patient enrollment before and after 2004 showed increased association of incomplete KD with CAA only among studies with patients enrolled after 2004 (OR = 1.969, 95 % CI = 1.240-3.127, p = 0.004). In conclusion, incomplete KD seems to be associated with an increased risk of CAA, and this is more prominent in patients younger than 12 months, Asians and Indians.

Original languageEnglish
Pages (from-to)343-349
Number of pages7
JournalEuropean Journal of Pediatrics
Volume172
Issue number3
DOIs
Publication statusPublished - 2013 Mar 1

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Mucocutaneous Lymph Node Syndrome
Meta-Analysis
Coronary Vessels
Odds Ratio
Confidence Intervals
Aneurysm

Keywords

  • Aneurysm
  • Coronary artery abnormality
  • Kawasaki disease-incomplete
  • Meta-analysis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Incomplete clinical manifestation as a risk factor for coronary artery abnormalities in Kawasaki disease : A meta-analysis. / Ha, Kee Soo; Jang, Giyoung; Lee, Jung Hwa; Lee, Kwang Chul; Hong, Young Sook; Son, Chang Sung; Lee, Joowon.

In: European Journal of Pediatrics, Vol. 172, No. 3, 01.03.2013, p. 343-349.

Research output: Contribution to journalArticle

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