Increased expression of ICAM-3 is associated with radiation resistance in cervical cancer

Young Min Chung, Byoung Gie Kim, Chans Soo Park, Seung Jae Huh, Jhingook Kim, Jong Kuk Park, Sun Mi Cho, Byung Soo Kim, Jun Suk Kim, Young Do Yoo, Duk Soo Bae

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

To search for a marker that predicts the efficacy of radiation therapy in human cervical cancer, gene expression profiles between parental SiHa cervical cancer cells and radiation-resistant SiHa/R cells have been compared by the microarray technique. Microarray and Northern blot analyses demonstrated that the ICAM-3 expression was upregulated in SiHa/R cells. This increased expression of ICAM-3 in SiHa cells enhanced cell survival by about 34.3% after a 2 Gy dosage of radiation. In addition, SiHa/ICAM-3 cells showed a 2.45-fold higher level of FAK phosphorylation than that of the control cells. In tumor specimens, ICAM-3 staining was restricted to tumor stromal endothelial cells and lymphocytes. The overexpression of ICAM-3 was significantly more frequent in radiation-resistant cervical cancer specimens when compared with radiation-sensitive specimens (83.3% vs. 35.3%; p = 0.015). With these observations, we can suggest that an increased expression of ICAM-3 is associated with radiation resistance in cervical cancer cells and the expression of ICAM-3 can be used as a valuable biomarker to predict the radiation resistance in cervical cancer that occurs during radiotherapy.

Original languageEnglish
Pages (from-to)194-201
Number of pages8
JournalInternational Journal of Cancer
Volume117
Issue number2
DOIs
Publication statusPublished - 2005 Nov 1

Keywords

  • Cervical cancer
  • FAK
  • ICAM-3
  • Microarray
  • Radiation resistance
  • SiHa

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Chung, Y. M., Kim, B. G., Park, C. S., Huh, S. J., Kim, J., Park, J. K., Cho, S. M., Kim, B. S., Kim, J. S., Yoo, Y. D., & Bae, D. S. (2005). Increased expression of ICAM-3 is associated with radiation resistance in cervical cancer. International Journal of Cancer, 117(2), 194-201. https://doi.org/10.1002/ijc.21180