Increased expression of IL-18 in cutaneous graft-versus-host disease

Hyun Jeong Park, Ji Eun Kim, Jun Yong Lee, Baik Kee Cho, Wang Jae Lee, Tae Sung Kim, Doyoung Yoon, Dae Ho Cho

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Interleukin-18 (IL-18) is an 18-kDa cytokine produced by lipopolysaccharide (LPS)-activated macrophages or Kupffer cells. In addition, IL-18 is also produced by many different types of cells and tissues, including epidermal keratinocytes, the adrenal cortex, and the brain. IL-18 acts on the immune system to increase IFN-γ production from T and NK cells to enhance NK cell cytotoxicity and to activate Th1 cell proliferation. It is considered that the tissue expression of cytokines and cell adhesion molecules such as ICAM-1 are common in graft-versus-host disease (GVHD). Recent evidence suggests that IL-18 is a cytokine relevant in the pathogenesis of GVHD. Despite the potential importance of IL-18 in GVHD, the distribution of IL-18 production in cutaneous GVHD has not been fully investigated. In this study, the expression of IL-18 in the cutaneous GVHD was investigated. Formalin-fixed, paraffin-embedded tissue sections were obtained, and immunohistochemical analysis was performed to detect IL-18 and ICAM-1 expression according to the acute and chronic GVHD. Immunohistochemical analysis confirmed the enhanced IL-18 expression levels in the early stage (grade 1) of acute GVHD and the late stage (sclerodermoid) of chronic GVHD compared to the other stages. In contrast, the ICAM-1 expression level was constant at all stages. Our findings indicate that IL-18 is a significant pathogenic indicator in cutaneous GVHD, and the tissue expression of IL-18 seems to be associated with the pathogenesis of acute and chronic GVHD.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalImmunology Letters
Volume95
Issue number1
DOIs
Publication statusPublished - 2004 Aug 15
Externally publishedYes

Fingerprint

Interleukin-18
Graft vs Host Disease
Skin
Intercellular Adhesion Molecule-1
Cytokines
Natural Killer Cells
Th1 Cells
Kupffer Cells
Adrenal Cortex
Cell Adhesion Molecules
Keratinocytes
Paraffin
Formaldehyde
Lipopolysaccharides
Immune System
Macrophages
Cell Proliferation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Increased expression of IL-18 in cutaneous graft-versus-host disease. / Park, Hyun Jeong; Kim, Ji Eun; Lee, Jun Yong; Cho, Baik Kee; Lee, Wang Jae; Kim, Tae Sung; Yoon, Doyoung; Cho, Dae Ho.

In: Immunology Letters, Vol. 95, No. 1, 15.08.2004, p. 57-61.

Research output: Contribution to journalArticle

Park, Hyun Jeong ; Kim, Ji Eun ; Lee, Jun Yong ; Cho, Baik Kee ; Lee, Wang Jae ; Kim, Tae Sung ; Yoon, Doyoung ; Cho, Dae Ho. / Increased expression of IL-18 in cutaneous graft-versus-host disease. In: Immunology Letters. 2004 ; Vol. 95, No. 1. pp. 57-61.
@article{5d0c26ae8fa04323ae4351a99ac551db,
title = "Increased expression of IL-18 in cutaneous graft-versus-host disease",
abstract = "Interleukin-18 (IL-18) is an 18-kDa cytokine produced by lipopolysaccharide (LPS)-activated macrophages or Kupffer cells. In addition, IL-18 is also produced by many different types of cells and tissues, including epidermal keratinocytes, the adrenal cortex, and the brain. IL-18 acts on the immune system to increase IFN-γ production from T and NK cells to enhance NK cell cytotoxicity and to activate Th1 cell proliferation. It is considered that the tissue expression of cytokines and cell adhesion molecules such as ICAM-1 are common in graft-versus-host disease (GVHD). Recent evidence suggests that IL-18 is a cytokine relevant in the pathogenesis of GVHD. Despite the potential importance of IL-18 in GVHD, the distribution of IL-18 production in cutaneous GVHD has not been fully investigated. In this study, the expression of IL-18 in the cutaneous GVHD was investigated. Formalin-fixed, paraffin-embedded tissue sections were obtained, and immunohistochemical analysis was performed to detect IL-18 and ICAM-1 expression according to the acute and chronic GVHD. Immunohistochemical analysis confirmed the enhanced IL-18 expression levels in the early stage (grade 1) of acute GVHD and the late stage (sclerodermoid) of chronic GVHD compared to the other stages. In contrast, the ICAM-1 expression level was constant at all stages. Our findings indicate that IL-18 is a significant pathogenic indicator in cutaneous GVHD, and the tissue expression of IL-18 seems to be associated with the pathogenesis of acute and chronic GVHD.",
keywords = "Acute GVHD, Chronic GVHD, IL-18",
author = "Park, {Hyun Jeong} and Kim, {Ji Eun} and Lee, {Jun Yong} and Cho, {Baik Kee} and Lee, {Wang Jae} and Kim, {Tae Sung} and Doyoung Yoon and Cho, {Dae Ho}",
year = "2004",
month = "8",
day = "15",
doi = "10.1016/j.imlet.2004.06.011",
language = "English",
volume = "95",
pages = "57--61",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Increased expression of IL-18 in cutaneous graft-versus-host disease

AU - Park, Hyun Jeong

AU - Kim, Ji Eun

AU - Lee, Jun Yong

AU - Cho, Baik Kee

AU - Lee, Wang Jae

AU - Kim, Tae Sung

AU - Yoon, Doyoung

AU - Cho, Dae Ho

PY - 2004/8/15

Y1 - 2004/8/15

N2 - Interleukin-18 (IL-18) is an 18-kDa cytokine produced by lipopolysaccharide (LPS)-activated macrophages or Kupffer cells. In addition, IL-18 is also produced by many different types of cells and tissues, including epidermal keratinocytes, the adrenal cortex, and the brain. IL-18 acts on the immune system to increase IFN-γ production from T and NK cells to enhance NK cell cytotoxicity and to activate Th1 cell proliferation. It is considered that the tissue expression of cytokines and cell adhesion molecules such as ICAM-1 are common in graft-versus-host disease (GVHD). Recent evidence suggests that IL-18 is a cytokine relevant in the pathogenesis of GVHD. Despite the potential importance of IL-18 in GVHD, the distribution of IL-18 production in cutaneous GVHD has not been fully investigated. In this study, the expression of IL-18 in the cutaneous GVHD was investigated. Formalin-fixed, paraffin-embedded tissue sections were obtained, and immunohistochemical analysis was performed to detect IL-18 and ICAM-1 expression according to the acute and chronic GVHD. Immunohistochemical analysis confirmed the enhanced IL-18 expression levels in the early stage (grade 1) of acute GVHD and the late stage (sclerodermoid) of chronic GVHD compared to the other stages. In contrast, the ICAM-1 expression level was constant at all stages. Our findings indicate that IL-18 is a significant pathogenic indicator in cutaneous GVHD, and the tissue expression of IL-18 seems to be associated with the pathogenesis of acute and chronic GVHD.

AB - Interleukin-18 (IL-18) is an 18-kDa cytokine produced by lipopolysaccharide (LPS)-activated macrophages or Kupffer cells. In addition, IL-18 is also produced by many different types of cells and tissues, including epidermal keratinocytes, the adrenal cortex, and the brain. IL-18 acts on the immune system to increase IFN-γ production from T and NK cells to enhance NK cell cytotoxicity and to activate Th1 cell proliferation. It is considered that the tissue expression of cytokines and cell adhesion molecules such as ICAM-1 are common in graft-versus-host disease (GVHD). Recent evidence suggests that IL-18 is a cytokine relevant in the pathogenesis of GVHD. Despite the potential importance of IL-18 in GVHD, the distribution of IL-18 production in cutaneous GVHD has not been fully investigated. In this study, the expression of IL-18 in the cutaneous GVHD was investigated. Formalin-fixed, paraffin-embedded tissue sections were obtained, and immunohistochemical analysis was performed to detect IL-18 and ICAM-1 expression according to the acute and chronic GVHD. Immunohistochemical analysis confirmed the enhanced IL-18 expression levels in the early stage (grade 1) of acute GVHD and the late stage (sclerodermoid) of chronic GVHD compared to the other stages. In contrast, the ICAM-1 expression level was constant at all stages. Our findings indicate that IL-18 is a significant pathogenic indicator in cutaneous GVHD, and the tissue expression of IL-18 seems to be associated with the pathogenesis of acute and chronic GVHD.

KW - Acute GVHD

KW - Chronic GVHD

KW - IL-18

UR - http://www.scopus.com/inward/record.url?scp=4344573548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4344573548&partnerID=8YFLogxK

U2 - 10.1016/j.imlet.2004.06.011

DO - 10.1016/j.imlet.2004.06.011

M3 - Article

C2 - 15325798

AN - SCOPUS:4344573548

VL - 95

SP - 57

EP - 61

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

IS - 1

ER -