Increased expression of resistin in ectopic endometrial tissue of women with endometriosis

Yoon Kyung Oh, Young Ran Ha, Kyong Wook Yi, Hyun-Tae Park, Jung-Ho Shin, Tak Kim, Jun Young Hur

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Problem: Inflammation is a key process in the establishment and progression of endometriosis. Resistin, an adipocytokine, has biological properties linked to immunologic functions, but its role in endometriosis is unclear. Method of study: Resistin gene expression was examined in eutopic and ectopic endometrial tissues from women with (n=25) or without (n=25) endometriosis. Resistin mRNA and protein levels were determined in endometrial tissue using quantitative real-time reverse transcription PCR and Western blotting, following adipokine profiling arrays. Results: Resistin protein was detected in human endometrial tissues using an adipokine array test. Resistin mRNA and protein levels were significantly higher in ectopic endometrial tissue of patients with endometriosis than in normal eutopic endometrial tissue. Conclusion: Our results indicate that resistin is differentially expressed in endometrial tissues from women with endometriosis and imply a role for resistin in endometriosis-associated pelvic inflammation.

Original languageEnglish
Article numbere12726
JournalAmerican Journal of Reproductive Immunology
Volume78
Issue number5
DOIs
Publication statusPublished - 2017 Jan 1

Keywords

  • adipokine
  • endometriosis
  • inflammation
  • resistin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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