Increased laryngeal lavage lipid-laden macrophage index during acute bronchiolitis

Chang Keun Kim, Hyo Bin Kim, Twinkle Kurian, Ju Young Chung, Young Yoo, Young Yull Koh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: To investigate aspiration risks associated with bronchiolitis in infants using the lipid-laden macrophage index (LLMI) from laryngeal lavages. Methods: Laryngeal lavages from 29 infants with acute bronchiolitis caused by respiratory syncytial virus were evaluated (acute stage). Repeated studies were then performed at 3-4 weeks after the initial study (remission stage). Lavage cell counts and differentials were determined. The amount of lipid per single macrophage was evaluated and the LLMI was determined by evaluating 100 cells. In addition, 24-h pH monitoring (pHm) was performed in 16 patients. Results: The LLMIs in the acute stage were significantly higher than those in the remission stage (p < 0.05). The neutrophil percentage of the laryngeal lavage correlated significantly with the LLMI (r = 0.707, p < 0.0001) during the acute stage of bronchiolitis. When patients were divided into pHm-positive (n = 5) and pHm-negative (n = 11) subgroups, a significant decrease in LLMI between acute and remission stages was noted among the pHm-positive (p < 0.01) subgroup, but not in the pHm-negative subgroup. Conclusion: These findings suggest that there is a transient increased LLMI in patients with bronchiolitis, which could be caused by gastroesophageal reflux.

Original languageEnglish
Pages (from-to)1025-1029
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Volume96
Issue number7
DOIs
Publication statusPublished - 2007 Jul 1

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Bronchiolitis
Therapeutic Irrigation
Macrophages
Lipids
Respiratory Syncytial Viruses
Gastroesophageal Reflux
Neutrophils
Cell Count

Keywords

  • Aspiration
  • Bronchiolitis
  • Laryngeal lavage
  • Lipid-laden macrophage index

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Increased laryngeal lavage lipid-laden macrophage index during acute bronchiolitis. / Kim, Chang Keun; Kim, Hyo Bin; Kurian, Twinkle; Chung, Ju Young; Yoo, Young; Koh, Young Yull.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 96, No. 7, 01.07.2007, p. 1025-1029.

Research output: Contribution to journalArticle

Kim, Chang Keun ; Kim, Hyo Bin ; Kurian, Twinkle ; Chung, Ju Young ; Yoo, Young ; Koh, Young Yull. / Increased laryngeal lavage lipid-laden macrophage index during acute bronchiolitis. In: Acta Paediatrica, International Journal of Paediatrics. 2007 ; Vol. 96, No. 7. pp. 1025-1029.
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