Increased liver stiffness in extrahepatic cholestasis caused by choledocholithiasis

Anca Trifan, Catalin Sfarti, Camelia Cojocariu, Mihaela Dimache, Maria Cretu, Catalin Hutanasu, Carol Stanciu, Yeon Seok Seo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Extrahepatic cholestasis that is caused by benign and malignant diseases has been reported to increase liver stifness (LS), as measured by transient elastogra-phy (TE).Objectives: The aim of this study was to evaluate LS in patients with extrahepatic cholestasis due to choledocholithiasis before and after endoscopic sphincterotomy and stone removal.Patients and Methods: LS was measured by TE (Fibroscan) in patients with extrahepatic cholestasis that was caused by choledocholithiasis before and 1 month after endoscopic sphincterotomy and successful stone removal.Results: We studied 12 patients (7 females, 5 males), aged 36 to 76 years (mean age 57.1 ± 11.6 years), with extrahepatic cholestasis that was caused by choledocholithiasis. LS was increased in all patients (range: 6.2-18.4 kPa; mean: 8.9 ± 3.5 kPa) before endoscopic therapy. Successful biliary drainage was efected by sphincterotomy and stone removal in all patients, which led to a signifcant decline in LS to 3.9-8.1 kPa (Mean: 5.6 ± 1.2 kPa; p < 0.001) within a mean observation time of 29 days. The decrease in LS values correlated signifcantly with a decline in serum total bilirubin levels (r = 0.691; p < 0.0001).Conclusions: Extrahepatic cholestasis due to choledocholithiasis increases LS and should be excluded before assesing liver fbrosis by transient elastography

Original languageEnglish
Pages (from-to)372-375
Number of pages4
JournalHepatitis Monthly
Volume11
Issue number5
Publication statusPublished - 2011 May 1

Fingerprint

Extrahepatic Cholestasis
Choledocholithiasis
Liver
Endoscopic Sphincterotomy
Elasticity Imaging Techniques
Bilirubin
Drainage
Observation

Keywords

  • Extrahepatic cholestasis
  • Liver stiffness
  • Transient elastography

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

Cite this

Trifan, A., Sfarti, C., Cojocariu, C., Dimache, M., Cretu, M., Hutanasu, C., ... Seo, Y. S. (2011). Increased liver stiffness in extrahepatic cholestasis caused by choledocholithiasis. Hepatitis Monthly, 11(5), 372-375.

Increased liver stiffness in extrahepatic cholestasis caused by choledocholithiasis. / Trifan, Anca; Sfarti, Catalin; Cojocariu, Camelia; Dimache, Mihaela; Cretu, Maria; Hutanasu, Catalin; Stanciu, Carol; Seo, Yeon Seok.

In: Hepatitis Monthly, Vol. 11, No. 5, 01.05.2011, p. 372-375.

Research output: Contribution to journalArticle

Trifan, A, Sfarti, C, Cojocariu, C, Dimache, M, Cretu, M, Hutanasu, C, Stanciu, C & Seo, YS 2011, 'Increased liver stiffness in extrahepatic cholestasis caused by choledocholithiasis', Hepatitis Monthly, vol. 11, no. 5, pp. 372-375.
Trifan A, Sfarti C, Cojocariu C, Dimache M, Cretu M, Hutanasu C et al. Increased liver stiffness in extrahepatic cholestasis caused by choledocholithiasis. Hepatitis Monthly. 2011 May 1;11(5):372-375.
Trifan, Anca ; Sfarti, Catalin ; Cojocariu, Camelia ; Dimache, Mihaela ; Cretu, Maria ; Hutanasu, Catalin ; Stanciu, Carol ; Seo, Yeon Seok. / Increased liver stiffness in extrahepatic cholestasis caused by choledocholithiasis. In: Hepatitis Monthly. 2011 ; Vol. 11, No. 5. pp. 372-375.
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abstract = "Background: Extrahepatic cholestasis that is caused by benign and malignant diseases has been reported to increase liver stifness (LS), as measured by transient elastogra-phy (TE).Objectives: The aim of this study was to evaluate LS in patients with extrahepatic cholestasis due to choledocholithiasis before and after endoscopic sphincterotomy and stone removal.Patients and Methods: LS was measured by TE (Fibroscan) in patients with extrahepatic cholestasis that was caused by choledocholithiasis before and 1 month after endoscopic sphincterotomy and successful stone removal.Results: We studied 12 patients (7 females, 5 males), aged 36 to 76 years (mean age 57.1 ± 11.6 years), with extrahepatic cholestasis that was caused by choledocholithiasis. LS was increased in all patients (range: 6.2-18.4 kPa; mean: 8.9 ± 3.5 kPa) before endoscopic therapy. Successful biliary drainage was efected by sphincterotomy and stone removal in all patients, which led to a signifcant decline in LS to 3.9-8.1 kPa (Mean: 5.6 ± 1.2 kPa; p < 0.001) within a mean observation time of 29 days. The decrease in LS values correlated signifcantly with a decline in serum total bilirubin levels (r = 0.691; p < 0.0001).Conclusions: Extrahepatic cholestasis due to choledocholithiasis increases LS and should be excluded before assesing liver fbrosis by transient elastography",
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AU - Stanciu, Carol

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N2 - Background: Extrahepatic cholestasis that is caused by benign and malignant diseases has been reported to increase liver stifness (LS), as measured by transient elastogra-phy (TE).Objectives: The aim of this study was to evaluate LS in patients with extrahepatic cholestasis due to choledocholithiasis before and after endoscopic sphincterotomy and stone removal.Patients and Methods: LS was measured by TE (Fibroscan) in patients with extrahepatic cholestasis that was caused by choledocholithiasis before and 1 month after endoscopic sphincterotomy and successful stone removal.Results: We studied 12 patients (7 females, 5 males), aged 36 to 76 years (mean age 57.1 ± 11.6 years), with extrahepatic cholestasis that was caused by choledocholithiasis. LS was increased in all patients (range: 6.2-18.4 kPa; mean: 8.9 ± 3.5 kPa) before endoscopic therapy. Successful biliary drainage was efected by sphincterotomy and stone removal in all patients, which led to a signifcant decline in LS to 3.9-8.1 kPa (Mean: 5.6 ± 1.2 kPa; p < 0.001) within a mean observation time of 29 days. The decrease in LS values correlated signifcantly with a decline in serum total bilirubin levels (r = 0.691; p < 0.0001).Conclusions: Extrahepatic cholestasis due to choledocholithiasis increases LS and should be excluded before assesing liver fbrosis by transient elastography

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