Increased nitric oxide synthase immunoreactivity in rat dorsal root ganglia in a neuropathic pain model

Jennifer H. Steel, Giorgio Terenghi, Jin Mo Chung, Heung Sik Na, Susan M. Carlton, Julia M. Polak

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

In rats, tight ligation of L5 and L6 spinal nerves produces symptoms of thermal hyperalgesia and mechanical allodynia, mimicking the symptoms which characterise painful peripheral neuropathies in humans. Immunoreactivity for nitric oxide synthase (NOS) was investigated in lumbar (L1, L4, L5 and L6) dorsal root ganglia from naive controls and from rats surviving for 3, 7, and 14 days after unilateral ligation of the L5 and L6 spinal nerves. Quantitative analysis revealed significant increases in the percentage of NOS-immunoreactive cell profiles in L5 and L6 ganglia on the operated side at all time points, with the number of labelled profiles increasing with time following ligation, but L1 and L4 ganglia were unaffected. These findings suggest that nitric oxide may have a role in the generation and/or maintenance of neuropathic pain.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Volume169
Issue number1-2
Publication statusPublished - 1994 Mar 14
Externally publishedYes

Fingerprint

Hyperalgesia
Spinal Ganglia
Neuralgia
Nitric Oxide Synthase
Ligation
Spinal Nerves
Ganglia
Peripheral Nervous System Diseases
Nitric Oxide
Maintenance

Keywords

  • Dorsal root ganglion
  • Nerve ligation
  • Neuropathic pain
  • Nitric oxide synthase
  • Quantitative immunocytochemistry

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Steel, J. H., Terenghi, G., Chung, J. M., Na, H. S., Carlton, S. M., & Polak, J. M. (1994). Increased nitric oxide synthase immunoreactivity in rat dorsal root ganglia in a neuropathic pain model. Neuroscience Letters, 169(1-2), 81-84.

Increased nitric oxide synthase immunoreactivity in rat dorsal root ganglia in a neuropathic pain model. / Steel, Jennifer H.; Terenghi, Giorgio; Chung, Jin Mo; Na, Heung Sik; Carlton, Susan M.; Polak, Julia M.

In: Neuroscience Letters, Vol. 169, No. 1-2, 14.03.1994, p. 81-84.

Research output: Contribution to journalArticle

Steel, JH, Terenghi, G, Chung, JM, Na, HS, Carlton, SM & Polak, JM 1994, 'Increased nitric oxide synthase immunoreactivity in rat dorsal root ganglia in a neuropathic pain model', Neuroscience Letters, vol. 169, no. 1-2, pp. 81-84.
Steel, Jennifer H. ; Terenghi, Giorgio ; Chung, Jin Mo ; Na, Heung Sik ; Carlton, Susan M. ; Polak, Julia M. / Increased nitric oxide synthase immunoreactivity in rat dorsal root ganglia in a neuropathic pain model. In: Neuroscience Letters. 1994 ; Vol. 169, No. 1-2. pp. 81-84.
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