Increased plasma complement factor H is associated with geriatric depression

Cheolmin Shin, Byung-Joo Ham, Young-Hoon Ko, Chi Un Pae, Moon Ho Park, David C. Steffens, Ashwin A. Patkar, Changsu Han

Research output: Contribution to journalArticle

Abstract

Background:: Complement factor H (CFH) plays a key role in regulating the cascade of the alternative pathway of the complement system. Dysregulation of CFH may be involved in the pathophysiology of various inflammation-mediated diseases including neuropsychiatric illnesses. This study aimed to investigate this relationship by examining determining CFH levels in elderly individuals with and without depression. Methods:: A total of 152 elderly individuals (major depressive disorder (MDD) group, n = 76; comparison sample, n = 76) were selected from the Ansan Geriatric study. The plasma level of CFH was measured. MDD was diagnosed with the Mini-International Neuropsychiatric Interview as per DSM-IV criteria. The severity of depression was evaluated with the geriatric depression scale (GDS). Mean CFH levels were compared using the Mann–Whitney U test. After adjusting for possible confounding factors including age, sex, marital status, education, alcohol use, hemoglobin levels, and the Korean version of the Mini-Mental State Examination (MMSE-KC), a multiple regression analysis was conducted. The GDS score and plasma level of CFH were analyzed using Spearman's correlation. Results:: Plasma CFH level was significantly higher in individuals with MDD than in the comparison sample (289.51 ± 21.16 vs. 339.67 ± 66.23, p < 0.001). In a regression model adjusted for possible confounders, CFH was significantly associated with geriatric depression (p < 0.001). CFH levels were not significantly related to GDS scores in the depressed group. Conclusion:: This study revealed an association between high plasma levels of CFH and geriatric depression, thereby suggesting the alternative pathway of the complement system contributing to the development of geriatric depression.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalInternational Psychogeriatrics
DOIs
Publication statusAccepted/In press - 2018 May 25

Fingerprint

Complement Factor H
Geriatrics
Depression
Major Depressive Disorder
Alternative Complement Pathway
Age Factors
Marital Status
Diagnostic and Statistical Manual of Mental Disorders
Hemoglobins
Regression Analysis
Alcohols
Interviews
Inflammation

Keywords

  • alternative pathway
  • complement factor H
  • complement system
  • geriatric depression

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Increased plasma complement factor H is associated with geriatric depression. / Shin, Cheolmin; Ham, Byung-Joo; Ko, Young-Hoon; Pae, Chi Un; Park, Moon Ho; Steffens, David C.; Patkar, Ashwin A.; Han, Changsu.

In: International Psychogeriatrics, 25.05.2018, p. 1-8.

Research output: Contribution to journalArticle

@article{ac9f9934258c4d88bc90aa34180b4059,
title = "Increased plasma complement factor H is associated with geriatric depression",
abstract = "Background:: Complement factor H (CFH) plays a key role in regulating the cascade of the alternative pathway of the complement system. Dysregulation of CFH may be involved in the pathophysiology of various inflammation-mediated diseases including neuropsychiatric illnesses. This study aimed to investigate this relationship by examining determining CFH levels in elderly individuals with and without depression. Methods:: A total of 152 elderly individuals (major depressive disorder (MDD) group, n = 76; comparison sample, n = 76) were selected from the Ansan Geriatric study. The plasma level of CFH was measured. MDD was diagnosed with the Mini-International Neuropsychiatric Interview as per DSM-IV criteria. The severity of depression was evaluated with the geriatric depression scale (GDS). Mean CFH levels were compared using the Mann–Whitney U test. After adjusting for possible confounding factors including age, sex, marital status, education, alcohol use, hemoglobin levels, and the Korean version of the Mini-Mental State Examination (MMSE-KC), a multiple regression analysis was conducted. The GDS score and plasma level of CFH were analyzed using Spearman's correlation. Results:: Plasma CFH level was significantly higher in individuals with MDD than in the comparison sample (289.51 ± 21.16 vs. 339.67 ± 66.23, p < 0.001). In a regression model adjusted for possible confounders, CFH was significantly associated with geriatric depression (p < 0.001). CFH levels were not significantly related to GDS scores in the depressed group. Conclusion:: This study revealed an association between high plasma levels of CFH and geriatric depression, thereby suggesting the alternative pathway of the complement system contributing to the development of geriatric depression.",
keywords = "alternative pathway, complement factor H, complement system, geriatric depression",
author = "Cheolmin Shin and Byung-Joo Ham and Young-Hoon Ko and Pae, {Chi Un} and Park, {Moon Ho} and Steffens, {David C.} and Patkar, {Ashwin A.} and Changsu Han",
year = "2018",
month = "5",
day = "25",
doi = "10.1017/S1041610218000558",
language = "English",
pages = "1--8",
journal = "International Psychogeriatrics",
issn = "1041-6102",
publisher = "Cambridge University Press",

}

TY - JOUR

T1 - Increased plasma complement factor H is associated with geriatric depression

AU - Shin, Cheolmin

AU - Ham, Byung-Joo

AU - Ko, Young-Hoon

AU - Pae, Chi Un

AU - Park, Moon Ho

AU - Steffens, David C.

AU - Patkar, Ashwin A.

AU - Han, Changsu

PY - 2018/5/25

Y1 - 2018/5/25

N2 - Background:: Complement factor H (CFH) plays a key role in regulating the cascade of the alternative pathway of the complement system. Dysregulation of CFH may be involved in the pathophysiology of various inflammation-mediated diseases including neuropsychiatric illnesses. This study aimed to investigate this relationship by examining determining CFH levels in elderly individuals with and without depression. Methods:: A total of 152 elderly individuals (major depressive disorder (MDD) group, n = 76; comparison sample, n = 76) were selected from the Ansan Geriatric study. The plasma level of CFH was measured. MDD was diagnosed with the Mini-International Neuropsychiatric Interview as per DSM-IV criteria. The severity of depression was evaluated with the geriatric depression scale (GDS). Mean CFH levels were compared using the Mann–Whitney U test. After adjusting for possible confounding factors including age, sex, marital status, education, alcohol use, hemoglobin levels, and the Korean version of the Mini-Mental State Examination (MMSE-KC), a multiple regression analysis was conducted. The GDS score and plasma level of CFH were analyzed using Spearman's correlation. Results:: Plasma CFH level was significantly higher in individuals with MDD than in the comparison sample (289.51 ± 21.16 vs. 339.67 ± 66.23, p < 0.001). In a regression model adjusted for possible confounders, CFH was significantly associated with geriatric depression (p < 0.001). CFH levels were not significantly related to GDS scores in the depressed group. Conclusion:: This study revealed an association between high plasma levels of CFH and geriatric depression, thereby suggesting the alternative pathway of the complement system contributing to the development of geriatric depression.

AB - Background:: Complement factor H (CFH) plays a key role in regulating the cascade of the alternative pathway of the complement system. Dysregulation of CFH may be involved in the pathophysiology of various inflammation-mediated diseases including neuropsychiatric illnesses. This study aimed to investigate this relationship by examining determining CFH levels in elderly individuals with and without depression. Methods:: A total of 152 elderly individuals (major depressive disorder (MDD) group, n = 76; comparison sample, n = 76) were selected from the Ansan Geriatric study. The plasma level of CFH was measured. MDD was diagnosed with the Mini-International Neuropsychiatric Interview as per DSM-IV criteria. The severity of depression was evaluated with the geriatric depression scale (GDS). Mean CFH levels were compared using the Mann–Whitney U test. After adjusting for possible confounding factors including age, sex, marital status, education, alcohol use, hemoglobin levels, and the Korean version of the Mini-Mental State Examination (MMSE-KC), a multiple regression analysis was conducted. The GDS score and plasma level of CFH were analyzed using Spearman's correlation. Results:: Plasma CFH level was significantly higher in individuals with MDD than in the comparison sample (289.51 ± 21.16 vs. 339.67 ± 66.23, p < 0.001). In a regression model adjusted for possible confounders, CFH was significantly associated with geriatric depression (p < 0.001). CFH levels were not significantly related to GDS scores in the depressed group. Conclusion:: This study revealed an association between high plasma levels of CFH and geriatric depression, thereby suggesting the alternative pathway of the complement system contributing to the development of geriatric depression.

KW - alternative pathway

KW - complement factor H

KW - complement system

KW - geriatric depression

UR - http://www.scopus.com/inward/record.url?scp=85047433589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047433589&partnerID=8YFLogxK

U2 - 10.1017/S1041610218000558

DO - 10.1017/S1041610218000558

M3 - Article

SP - 1

EP - 8

JO - International Psychogeriatrics

JF - International Psychogeriatrics

SN - 1041-6102

ER -