Increased plasma nitric oxide metabolites in suicide attempters

Bun Hee Lee; Sung Woo Lee; Dokyung Yoon; Heon Jeong Lee; Jong Chul Yang; Se Hoon Shim; Do Hoon Kim; Seung Ho Ryu; Changsu Han; Yong Ku Kim

doi:10.1159/000092542

Increased plasma nitric oxide metabolites in suicide attempters

Bun Hee Lee, Sung Woo Lee, Dokyung Yoon, Heon Jeong Lee, Jong Chul Yang, Se Hoon Shim, Do Hoon Kim, Seung Ho Ryu, Changsu Han, Yong Ku Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Objective: To evaluate any correlation between plasma levels of nitric oxide metabolites (NO_x) and suicide attempt. Method: Plasma NO _x levels were measured in 53 patients who had recently attempted suicide, 58 nonsuicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale. Results: Plasma NO_x levels were significantly higher in suicidal patients than nonsuicidal psychiatric patients or normal control subjects (F = 11.029, d.f. = 2, 183, p < 0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NO_x levels than nonsuicidal depressive patients (t = -3.090, d.f. = 84, p = 0.003). Conclusion: Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients.

Original language	English
Pages (from-to)	127-132
Number of pages	6
Journal	Neuropsychobiology
Volume	53
Issue number	3
DOIs	https://doi.org/10.1159/000092542
Publication status	Published - 2006 Jun

Keywords

Bipolar disorder
Depression
Nitric oxide
Risk-rescue rating scale
Schizophrenia
Suicide

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000092542

Cite this

@article{bc1587ba8019454ebf3e80eba2cf5585,

title = "Increased plasma nitric oxide metabolites in suicide attempters",

abstract = "Objective: To evaluate any correlation between plasma levels of nitric oxide metabolites (NOx) and suicide attempt. Method: Plasma NO x levels were measured in 53 patients who had recently attempted suicide, 58 nonsuicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale. Results: Plasma NOx levels were significantly higher in suicidal patients than nonsuicidal psychiatric patients or normal control subjects (F = 11.029, d.f. = 2, 183, p < 0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NOx levels than nonsuicidal depressive patients (t = -3.090, d.f. = 84, p = 0.003). Conclusion: Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients.",

keywords = "Bipolar disorder, Depression, Nitric oxide, Risk-rescue rating scale, Schizophrenia, Suicide",

author = "Lee, {Bun Hee} and Lee, {Sung Woo} and Dokyung Yoon and Lee, {Heon Jeong} and Yang, {Jong Chul} and Shim, {Se Hoon} and Kim, {Do Hoon} and Ryu, {Seung Ho} and Changsu Han and Kim, {Yong Ku}",

year = "2006",

month = jun,

doi = "10.1159/000092542",

language = "English",

volume = "53",

pages = "127--132",

journal = "Neuropsychobiology",

issn = "0302-282X",

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TY - JOUR

T1 - Increased plasma nitric oxide metabolites in suicide attempters

AU - Lee, Bun Hee

AU - Lee, Sung Woo

AU - Yoon, Dokyung

AU - Lee, Heon Jeong

AU - Yang, Jong Chul

AU - Shim, Se Hoon

AU - Kim, Do Hoon

AU - Ryu, Seung Ho

AU - Han, Changsu

AU - Kim, Yong Ku

PY - 2006/6

Y1 - 2006/6

N2 - Objective: To evaluate any correlation between plasma levels of nitric oxide metabolites (NOx) and suicide attempt. Method: Plasma NO x levels were measured in 53 patients who had recently attempted suicide, 58 nonsuicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale. Results: Plasma NOx levels were significantly higher in suicidal patients than nonsuicidal psychiatric patients or normal control subjects (F = 11.029, d.f. = 2, 183, p < 0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NOx levels than nonsuicidal depressive patients (t = -3.090, d.f. = 84, p = 0.003). Conclusion: Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients.

AB - Objective: To evaluate any correlation between plasma levels of nitric oxide metabolites (NOx) and suicide attempt. Method: Plasma NO x levels were measured in 53 patients who had recently attempted suicide, 58 nonsuicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale. Results: Plasma NOx levels were significantly higher in suicidal patients than nonsuicidal psychiatric patients or normal control subjects (F = 11.029, d.f. = 2, 183, p < 0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NOx levels than nonsuicidal depressive patients (t = -3.090, d.f. = 84, p = 0.003). Conclusion: Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients.

KW - Bipolar disorder

KW - Depression

KW - Nitric oxide

KW - Risk-rescue rating scale

KW - Schizophrenia

KW - Suicide

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DO - 10.1159/000092542

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SN - 0302-282X

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SP - 127

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JO - Neuropsychobiology

JF - Neuropsychobiology

IS - 3

ER -

Increased plasma nitric oxide metabolites in suicide attempters

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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