Increased plasma nitric oxide metabolites in suicide attempters

Bun Hee Lee, Sung Woo Lee, Dokyung Yoon, Heon Jeong Lee, Jong Chul Yang, Se Hoon Shim, Do Hoon Kim, Seung Ho Ryu, Changsu Han, Yong Ku Kim

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objective: To evaluate any correlation between plasma levels of nitric oxide metabolites (NOx) and suicide attempt. Method: Plasma NO x levels were measured in 53 patients who had recently attempted suicide, 58 nonsuicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale. Results: Plasma NOx levels were significantly higher in suicidal patients than nonsuicidal psychiatric patients or normal control subjects (F = 11.029, d.f. = 2, 183, p < 0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NOx levels than nonsuicidal depressive patients (t = -3.090, d.f. = 84, p = 0.003). Conclusion: Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalNeuropsychobiology
Volume53
Issue number3
DOIs
Publication statusPublished - 2006 Jun

Keywords

  • Bipolar disorder
  • Depression
  • Nitric oxide
  • Risk-rescue rating scale
  • Schizophrenia
  • Suicide

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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