Increased plasma osmolar gap is predictive of contrast-induced acute kidney injury

Sejoong Kim, Jiyoon Sung, Woong Chul Kang, Shin Young Ahn, Dong Ki Kim, Ho Jun Chin, Ki Young Na, Kwon Wook Joo, Dong Wan Chae, Jin Suk Han

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Contrast-induced acute kidney injury (CIAKI) is a common complication after percutaneous coronary artery intervention (PCI). It is urgent to find a novel, easily measurable and accurate predictor for the early detection of CIAKI. Hyperosmolarity and large amounts of contrast media are risk factors for CIAKI. However, there is no study on plasma osmolar gap as a predictor of CIAKI. We enrolled 89 patients undergoing elective PCI and tested changes of serum sodium, osmolar gap, and renal function at 0, 6, 12 and 24 hours. Plasma osmolar gap was calculated using the following formula: measured plasma osmolarity - [2(Na) + serum urea nitrogen/2.8 + glucose/18]. CIAKI was defined as follows: increase in serum creatinine of ≥ 50%, increase in serum creatinine of ≥ 0.3 mg/dL, or decrease in estimated glomerular filtration rate of ≥ 25% within 24 hours after PCI. The incidence of CIAKI was 13.5% (12/89 patients). The CIAKI group had higher plasma osmolar gaps 6 hours after PCI. The adjusted hazard ratio of the plasma osmolar gap from hour 6 (1-mOsm/L increments) to the development of CIAKI was 1.12 (95% confidence interval [CI], 1.01-1.26; P = 0.041). Sensitivity and specificity of 7 mOsm/L or higher plasma osmolar gap at hour 6 were 70.0% and 76.6%, respectively (area under the ROC curve = 0.77 [95% CI, 0.65-0.89]). Increased plasma osmolar gap may precede the development of CIAKI in patients undergoing PCI. In conclusion, plasma osmolar gap may be a useful predictor for the development of CIAKI.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalTohoku Journal of Experimental Medicine
Volume228
Issue number2
DOIs
Publication statusPublished - 2012 Oct 30
Externally publishedYes

Fingerprint

Acute Kidney Injury
Plasmas
Percutaneous Coronary Intervention
Coronary Vessels
Creatinine
Serum
Confidence Intervals
Contrast Media
Urea
Hazards
Glomerular Filtration Rate
Nitrogen
ROC Curve
Sodium
Osmolar Concentration
Area Under Curve
Glucose
Kidney
Sensitivity and Specificity
Incidence

Keywords

  • Acute kidney injury
  • Biomarker
  • Contrast media
  • Coronary angiography
  • Osmolality

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Increased plasma osmolar gap is predictive of contrast-induced acute kidney injury. / Kim, Sejoong; Sung, Jiyoon; Kang, Woong Chul; Ahn, Shin Young; Kim, Dong Ki; Chin, Ho Jun; Na, Ki Young; Joo, Kwon Wook; Chae, Dong Wan; Han, Jin Suk.

In: Tohoku Journal of Experimental Medicine, Vol. 228, No. 2, 30.10.2012, p. 109-117.

Research output: Contribution to journalArticle

Kim, S, Sung, J, Kang, WC, Ahn, SY, Kim, DK, Chin, HJ, Na, KY, Joo, KW, Chae, DW & Han, JS 2012, 'Increased plasma osmolar gap is predictive of contrast-induced acute kidney injury', Tohoku Journal of Experimental Medicine, vol. 228, no. 2, pp. 109-117. https://doi.org/10.1620/tjem.228.109
Kim, Sejoong ; Sung, Jiyoon ; Kang, Woong Chul ; Ahn, Shin Young ; Kim, Dong Ki ; Chin, Ho Jun ; Na, Ki Young ; Joo, Kwon Wook ; Chae, Dong Wan ; Han, Jin Suk. / Increased plasma osmolar gap is predictive of contrast-induced acute kidney injury. In: Tohoku Journal of Experimental Medicine. 2012 ; Vol. 228, No. 2. pp. 109-117.
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abstract = "Contrast-induced acute kidney injury (CIAKI) is a common complication after percutaneous coronary artery intervention (PCI). It is urgent to find a novel, easily measurable and accurate predictor for the early detection of CIAKI. Hyperosmolarity and large amounts of contrast media are risk factors for CIAKI. However, there is no study on plasma osmolar gap as a predictor of CIAKI. We enrolled 89 patients undergoing elective PCI and tested changes of serum sodium, osmolar gap, and renal function at 0, 6, 12 and 24 hours. Plasma osmolar gap was calculated using the following formula: measured plasma osmolarity - [2(Na) + serum urea nitrogen/2.8 + glucose/18]. CIAKI was defined as follows: increase in serum creatinine of ≥ 50{\%}, increase in serum creatinine of ≥ 0.3 mg/dL, or decrease in estimated glomerular filtration rate of ≥ 25{\%} within 24 hours after PCI. The incidence of CIAKI was 13.5{\%} (12/89 patients). The CIAKI group had higher plasma osmolar gaps 6 hours after PCI. The adjusted hazard ratio of the plasma osmolar gap from hour 6 (1-mOsm/L increments) to the development of CIAKI was 1.12 (95{\%} confidence interval [CI], 1.01-1.26; P = 0.041). Sensitivity and specificity of 7 mOsm/L or higher plasma osmolar gap at hour 6 were 70.0{\%} and 76.6{\%}, respectively (area under the ROC curve = 0.77 [95{\%} CI, 0.65-0.89]). Increased plasma osmolar gap may precede the development of CIAKI in patients undergoing PCI. In conclusion, plasma osmolar gap may be a useful predictor for the development of CIAKI.",
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AU - Kim, Dong Ki

AU - Chin, Ho Jun

AU - Na, Ki Young

AU - Joo, Kwon Wook

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KW - Coronary angiography

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