Increased plasma VEGF levels in major depressive or manic episodes in patients with mood disorders

Bun Hee Lee, Yong Ku Kim

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Background: The neurotrophic hypothesis suggests that mood disorders are associated with dysfunction of neuronal networks under the influence of neurotrophic factors. Vascular endothelial growth factor (VEGF) is a neurotrophic factor as well as an angiogenic cytokine. Methods: We examined plasma VEGF levels in 35 unipolar patients who were diagnosed with current major depressive disorder (MDD), 35 bipolar patients who were diagnosed with bipolar I disorder, manic episode (BM), and 60 healthy controls. The severity of depressive or manic symptoms was measured using the Hamilton Depression Rating Scale (HDRS) or the Young Mania rating scale (YMRS), respectively. Results: Plasma VEGF levels were 163.28 ± 135.33 pg/mL in MDD patients, 199.82 ± 182.59 pg/mL in BM patients, and 110.05 ± 109.57 pg/mL in healthy controls. Both MDD and BM patients had significantly higher VEGF levels than healthy controls when controlling for BMI as a covariate (p = 0.010). Patients' VEGF levels were not correlated with either HDRS or YMRS scores. Limitations: We assessed plasma VEGF levels at one time point, and we did not determine the source of VEGF in our samples. Conclusions: Plasma VEGF levels were elevated in patients with acute episodes of major depressive disorder and bipolar disorder. Such an alteration of VEGF in acute episode, mood disorders may be associated with a neuroprotective role for VEGF.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalJournal of Affective Disorders
Volume136
Issue number1-2
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Mood Disorders
Vascular Endothelial Growth Factor A
Major Depressive Disorder
Bipolar Disorder
Nerve Growth Factors
Depression
Cytokines

Keywords

  • Bipolar disorder
  • Major depressive disorder
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Increased plasma VEGF levels in major depressive or manic episodes in patients with mood disorders. / Lee, Bun Hee; Kim, Yong Ku.

In: Journal of Affective Disorders, Vol. 136, No. 1-2, 01.01.2012, p. 181-184.

Research output: Contribution to journalArticle

@article{86b0582641c84fcebeccdd36cc406d1b,
title = "Increased plasma VEGF levels in major depressive or manic episodes in patients with mood disorders",
abstract = "Background: The neurotrophic hypothesis suggests that mood disorders are associated with dysfunction of neuronal networks under the influence of neurotrophic factors. Vascular endothelial growth factor (VEGF) is a neurotrophic factor as well as an angiogenic cytokine. Methods: We examined plasma VEGF levels in 35 unipolar patients who were diagnosed with current major depressive disorder (MDD), 35 bipolar patients who were diagnosed with bipolar I disorder, manic episode (BM), and 60 healthy controls. The severity of depressive or manic symptoms was measured using the Hamilton Depression Rating Scale (HDRS) or the Young Mania rating scale (YMRS), respectively. Results: Plasma VEGF levels were 163.28 ± 135.33 pg/mL in MDD patients, 199.82 ± 182.59 pg/mL in BM patients, and 110.05 ± 109.57 pg/mL in healthy controls. Both MDD and BM patients had significantly higher VEGF levels than healthy controls when controlling for BMI as a covariate (p = 0.010). Patients' VEGF levels were not correlated with either HDRS or YMRS scores. Limitations: We assessed plasma VEGF levels at one time point, and we did not determine the source of VEGF in our samples. Conclusions: Plasma VEGF levels were elevated in patients with acute episodes of major depressive disorder and bipolar disorder. Such an alteration of VEGF in acute episode, mood disorders may be associated with a neuroprotective role for VEGF.",
keywords = "Bipolar disorder, Major depressive disorder, Vascular endothelial growth factor",
author = "Lee, {Bun Hee} and Kim, {Yong Ku}",
year = "2012",
month = "1",
day = "1",
doi = "10.1016/j.jad.2011.07.021",
language = "English",
volume = "136",
pages = "181--184",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Increased plasma VEGF levels in major depressive or manic episodes in patients with mood disorders

AU - Lee, Bun Hee

AU - Kim, Yong Ku

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background: The neurotrophic hypothesis suggests that mood disorders are associated with dysfunction of neuronal networks under the influence of neurotrophic factors. Vascular endothelial growth factor (VEGF) is a neurotrophic factor as well as an angiogenic cytokine. Methods: We examined plasma VEGF levels in 35 unipolar patients who were diagnosed with current major depressive disorder (MDD), 35 bipolar patients who were diagnosed with bipolar I disorder, manic episode (BM), and 60 healthy controls. The severity of depressive or manic symptoms was measured using the Hamilton Depression Rating Scale (HDRS) or the Young Mania rating scale (YMRS), respectively. Results: Plasma VEGF levels were 163.28 ± 135.33 pg/mL in MDD patients, 199.82 ± 182.59 pg/mL in BM patients, and 110.05 ± 109.57 pg/mL in healthy controls. Both MDD and BM patients had significantly higher VEGF levels than healthy controls when controlling for BMI as a covariate (p = 0.010). Patients' VEGF levels were not correlated with either HDRS or YMRS scores. Limitations: We assessed plasma VEGF levels at one time point, and we did not determine the source of VEGF in our samples. Conclusions: Plasma VEGF levels were elevated in patients with acute episodes of major depressive disorder and bipolar disorder. Such an alteration of VEGF in acute episode, mood disorders may be associated with a neuroprotective role for VEGF.

AB - Background: The neurotrophic hypothesis suggests that mood disorders are associated with dysfunction of neuronal networks under the influence of neurotrophic factors. Vascular endothelial growth factor (VEGF) is a neurotrophic factor as well as an angiogenic cytokine. Methods: We examined plasma VEGF levels in 35 unipolar patients who were diagnosed with current major depressive disorder (MDD), 35 bipolar patients who were diagnosed with bipolar I disorder, manic episode (BM), and 60 healthy controls. The severity of depressive or manic symptoms was measured using the Hamilton Depression Rating Scale (HDRS) or the Young Mania rating scale (YMRS), respectively. Results: Plasma VEGF levels were 163.28 ± 135.33 pg/mL in MDD patients, 199.82 ± 182.59 pg/mL in BM patients, and 110.05 ± 109.57 pg/mL in healthy controls. Both MDD and BM patients had significantly higher VEGF levels than healthy controls when controlling for BMI as a covariate (p = 0.010). Patients' VEGF levels were not correlated with either HDRS or YMRS scores. Limitations: We assessed plasma VEGF levels at one time point, and we did not determine the source of VEGF in our samples. Conclusions: Plasma VEGF levels were elevated in patients with acute episodes of major depressive disorder and bipolar disorder. Such an alteration of VEGF in acute episode, mood disorders may be associated with a neuroprotective role for VEGF.

KW - Bipolar disorder

KW - Major depressive disorder

KW - Vascular endothelial growth factor

UR - http://www.scopus.com/inward/record.url?scp=84857038071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857038071&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2011.07.021

DO - 10.1016/j.jad.2011.07.021

M3 - Article

VL - 136

SP - 181

EP - 184

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1-2

ER -