Increased serum activity of matrix metalloproteinase-9 in patients with acute variceal bleeding

Oh Sang Kwon, Hyuk Sang Jung, Kyung Sook Bae, Young Kul Jung, Yeon Suk Kim, Duck Joo Choi, Yun Soo Kim, Ju Hyun Kim

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    Background/Aims: Matrix metalloproteinases (MMP)-2 and -9 can degrade essential components of vascular integrity. The aim of this study was to investigate the association between those MMPs and variceal bleeding (VB). Methods: Fifteen controls, 12 patients with acute ulcer bleeding (UB) group, 37 patients with varix (V group), and 35 patients with acute VB group were enrolled. Serum was obtained to measure MMP-2 and -9 activity by zymogram protease assays. Results: The activity levels of these compounds were compared with the controls' median value. The median MMP- 9 activity was 1.0 in controls, 1.05 in the UB group, 0.43 in the V group, and 0.96 in the VB group. The level of MMP- 9 activity was higher in the VB group than in the V group (p<0.001). In the VB group, there was a signifi cant decrease in MMP-9 activity over time after bleeding (p<0.001). The median MMP-2 activity level was 1.0 in controls, 1.01 in the UB group, 1.50 in the V group, and 1.55 in the VB group. The level of MMP-2 activity was similar in the VB and V groups. Conclusions: The level of MMP-9 activity increased in association with VB. The role of MMP-9 in the pathogenesis of VB should be verifi ed.

    Original languageEnglish
    Pages (from-to)249-255
    Number of pages7
    JournalGut and liver
    Volume6
    Issue number2
    DOIs
    Publication statusPublished - 2012 Apr

    Keywords

    • Esophageal and gastric varices
    • Hemorrhage
    • Matrix metalloproteinase 2
    • Matrix metalloproteinase 9

    ASJC Scopus subject areas

    • Hepatology
    • Gastroenterology

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