Increased serum interleukin-5 and vascular endothelial growth factor in children with acute mycoplasma pneumonia and wheeze

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Abstract

Acute mycoplasma pneumonia may be accompanied by wheeze in some children considered not to have asthma. The aim of the present study was to evaluate cytokine secretion in children with acute mycoplasma pneumonia and wheeze. We studied 58 patients with mycoplasma pneumonia (12 with wheeze, Group 1; 46 without wheeze, Group 2) and 36 patients of non-mycoplasma pneumonia (Group 3). Serum levels of interleukin (IL)-4, IL-5, interferon (IFN)-y, and vascular endothelial growth factor (VEGF) were measured using an enzyme-linked immunosorbent assay kits. The mean ± SD IL-5 level of Group 1 was 97.1 ± 73.0 pg/ml, which was significantly higher than that of Group 2 (28.2±32.2 pg/ml) and that of Group 3 (35.7 ±42.0 pg/ml). The mean ± SD VEGF level of Group 1 was 687.5 ± 385.8 pg/ml, which was significantly higher than that of Group 2 (310.0 ±251.9 pg/ml) and that of Group 3 (402.3 ±279.5 pg/ml). No significant differences in serum levels of IL-4, IFN-g, and IgE were observed between the groups. Our results show that children with mycoplasma pneumonia and wheeze have significantly higher serum levels of IL-5 and VEGF. These increased immune responses may be associated with the pathophysiological mechanisms by which the Mycoplasma pneumoniae contribute to the development of wheeze during acute mycoplasma pneumonia

Original languageEnglish
Pages (from-to)423-428
Number of pages6
JournalPediatric Pulmonology
Volume44
Issue number5
DOIs
Publication statusPublished - 2009 May 1

Fingerprint

Mycoplasma Pneumonia
Interleukin-5
Vascular Endothelial Growth Factor A
Serum
Interleukin-4
Interferons
Mycoplasma pneumoniae
Immunoglobulin E
Pneumonia
Asthma
Enzyme-Linked Immunosorbent Assay
Cytokines

Keywords

  • Children
  • Interleukin-5
  • Mycoplasma pneumonia
  • Vascular endothelial growth factor
  • Wheeze

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

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title = "Increased serum interleukin-5 and vascular endothelial growth factor in children with acute mycoplasma pneumonia and wheeze",
abstract = "Acute mycoplasma pneumonia may be accompanied by wheeze in some children considered not to have asthma. The aim of the present study was to evaluate cytokine secretion in children with acute mycoplasma pneumonia and wheeze. We studied 58 patients with mycoplasma pneumonia (12 with wheeze, Group 1; 46 without wheeze, Group 2) and 36 patients of non-mycoplasma pneumonia (Group 3). Serum levels of interleukin (IL)-4, IL-5, interferon (IFN)-y, and vascular endothelial growth factor (VEGF) were measured using an enzyme-linked immunosorbent assay kits. The mean ± SD IL-5 level of Group 1 was 97.1 ± 73.0 pg/ml, which was significantly higher than that of Group 2 (28.2±32.2 pg/ml) and that of Group 3 (35.7 ±42.0 pg/ml). The mean ± SD VEGF level of Group 1 was 687.5 ± 385.8 pg/ml, which was significantly higher than that of Group 2 (310.0 ±251.9 pg/ml) and that of Group 3 (402.3 ±279.5 pg/ml). No significant differences in serum levels of IL-4, IFN-g, and IgE were observed between the groups. Our results show that children with mycoplasma pneumonia and wheeze have significantly higher serum levels of IL-5 and VEGF. These increased immune responses may be associated with the pathophysiological mechanisms by which the Mycoplasma pneumoniae contribute to the development of wheeze during acute mycoplasma pneumonia",
keywords = "Children, Interleukin-5, Mycoplasma pneumonia, Vascular endothelial growth factor, Wheeze",
author = "Choi, {Ic Sun} and Byeon, {Jung Hye} and Young Yoo and Lee, {Kwang Chul} and Ji-Tae Choung",
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T1 - Increased serum interleukin-5 and vascular endothelial growth factor in children with acute mycoplasma pneumonia and wheeze

AU - Choi, Ic Sun

AU - Byeon, Jung Hye

AU - Yoo, Young

AU - Lee, Kwang Chul

AU - Choung, Ji-Tae

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N2 - Acute mycoplasma pneumonia may be accompanied by wheeze in some children considered not to have asthma. The aim of the present study was to evaluate cytokine secretion in children with acute mycoplasma pneumonia and wheeze. We studied 58 patients with mycoplasma pneumonia (12 with wheeze, Group 1; 46 without wheeze, Group 2) and 36 patients of non-mycoplasma pneumonia (Group 3). Serum levels of interleukin (IL)-4, IL-5, interferon (IFN)-y, and vascular endothelial growth factor (VEGF) were measured using an enzyme-linked immunosorbent assay kits. The mean ± SD IL-5 level of Group 1 was 97.1 ± 73.0 pg/ml, which was significantly higher than that of Group 2 (28.2±32.2 pg/ml) and that of Group 3 (35.7 ±42.0 pg/ml). The mean ± SD VEGF level of Group 1 was 687.5 ± 385.8 pg/ml, which was significantly higher than that of Group 2 (310.0 ±251.9 pg/ml) and that of Group 3 (402.3 ±279.5 pg/ml). No significant differences in serum levels of IL-4, IFN-g, and IgE were observed between the groups. Our results show that children with mycoplasma pneumonia and wheeze have significantly higher serum levels of IL-5 and VEGF. These increased immune responses may be associated with the pathophysiological mechanisms by which the Mycoplasma pneumoniae contribute to the development of wheeze during acute mycoplasma pneumonia

AB - Acute mycoplasma pneumonia may be accompanied by wheeze in some children considered not to have asthma. The aim of the present study was to evaluate cytokine secretion in children with acute mycoplasma pneumonia and wheeze. We studied 58 patients with mycoplasma pneumonia (12 with wheeze, Group 1; 46 without wheeze, Group 2) and 36 patients of non-mycoplasma pneumonia (Group 3). Serum levels of interleukin (IL)-4, IL-5, interferon (IFN)-y, and vascular endothelial growth factor (VEGF) were measured using an enzyme-linked immunosorbent assay kits. The mean ± SD IL-5 level of Group 1 was 97.1 ± 73.0 pg/ml, which was significantly higher than that of Group 2 (28.2±32.2 pg/ml) and that of Group 3 (35.7 ±42.0 pg/ml). The mean ± SD VEGF level of Group 1 was 687.5 ± 385.8 pg/ml, which was significantly higher than that of Group 2 (310.0 ±251.9 pg/ml) and that of Group 3 (402.3 ±279.5 pg/ml). No significant differences in serum levels of IL-4, IFN-g, and IgE were observed between the groups. Our results show that children with mycoplasma pneumonia and wheeze have significantly higher serum levels of IL-5 and VEGF. These increased immune responses may be associated with the pathophysiological mechanisms by which the Mycoplasma pneumoniae contribute to the development of wheeze during acute mycoplasma pneumonia

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