Increased shikonin production by hairy roots of Lithospermum erythrorhizon in two phase bubble column reactor

Sang Jun Sim, Ho Nam Chang

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Plant hairy root cultures of Lithospermum erythrorhizon were carried out to produce shikonin derivatives by employing in situ extraction with n-hexadecane in a shake flask and a bubble column bioreactor. Over 95 % shikonin produced was recovered in the n-hexadecane layer. In flask cultures the maximum concentration of shikonin with n-hexadecane extraction was 3 times higher than that obtained without extraction. In the two phase bubble column reactor, 572.6 mg/L of shikonin and 15.6 g/L of dry cell mass were obtained after 54 days. Shikonin was produced at a constant level of 10.6 mg/L day during this period.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalBiotechnology letters
Volume15
Issue number2
DOIs
Publication statusPublished - 1993 Feb

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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