Increased telomere length in patients with frontotemporal dementia syndrome

Eun Joo Kim, Seong Ho Koh, Jungsoon Ha, Duk L. Na, Sang Won Seo, Hee Jin Kim, Kyung Won Park, Jae Hong Lee, Jee Hoon Roh, Jay C. Kwon, Soo Jin Yoon, Na Yeon Jung, Jee H. Jeong, Jae Won Jang, Kee Hyung Park, Seong Hye Choi, Sang Yun Kim, Young Ho Park, Byeong C. Kim, Young Eun KimHyuk Sung Kwon, Hyun Hee Park, Jeong Hwa Jin

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Telomeres are repetitive DNA sequences of TTAGGG at the ends of chromosomes. Many studies have shown that telomere shortening is associated with aging-related diseases, such as cardiovascular diseases, hypertension, diabetes, cancer, and various neurodegenerative diseases, including Alzheimer's disease, vascular dementia, Parkinson's disease, and dementia with Lewy bodies. However, changes in telomere length (TL) in patients with frontotemporal dementia (FTD) syndrome are unclear. Accordingly, in this study, we assessed TL in blood samples from patients with FTD syndrome. Methods: Absolute TL was measured in peripheral blood leukocytes from 53 patients with FTD syndromes (25 with behavioral variant FTD, 19 with semantic variant primary progressive aphasia [PPA], six with nonfluent/agrammatic variant PPA, and three with amyotrophic lateral sclerosis [ALS] plus) and 28 cognitively unimpaired (CU) controls using terminal restriction fragment analysis. Results: TL was significantly longer in the FTD group than in the CU group. All FTD subtypes had significantly longer TL than controls. There were no significant differences in TL among FTD syndromes. No significant correlations were found between TL and demographic factors in the FTD group. Conclusions: Longer telomeres were associated with FTD syndrome, consistent with a recent report demonstrating that longer telomeres are related to ALS. Therefore, our results may support a shared biology between FTD and ALS. More studies with larger sample sizes are needed.

Original languageEnglish
Article number117565
JournalJournal of the Neurological Sciences
Volume428
DOIs
Publication statusPublished - 2021 Sep 15
Externally publishedYes

Keywords

  • Frontotemporal dementia
  • Telomere

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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