Increased transforming growth factor-beta1 in alcohol dependence

Yong Ku Kim; Boung Chul Lee; Byung Joo Ham; Byung Hwan Yang; Sungwon Roh; Joonho Choi; Tae Cheon Kang; Young Gyu Chai; Ihn Geun Choi

doi:10.3346/jkms.2009.24.5.941

Increased transforming growth factor-beta1 in alcohol dependence

Yong Ku Kim, Boung Chul Lee, Byung Joo Ham, Byung Hwan Yang, Sungwon Roh, Joonho Choi, Tae Cheon Kang, Young Gyu Chai, Ihn Geun Choi

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-β1) expression in animal studies. TGF-β1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-β1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-β1 levels in the patients with alcohol dependence (1,653.11 ±532.45 pg/mL) were significantly higher than those of healthy subjects (669.87 ±366.53 pg/mL) (P=0.000). Patients with or without liver pathology showed no difference in TGF-β1 (P=0.36). Increased TGF-β1 may mediate deleterious effect of alcohol such as hepatic fibrosis and suppressed neuronal developments in alcohol dependence patients.

Original language	English
Pages (from-to)	941-944
Number of pages	4
Journal	Journal of Korean medical science
Volume	24
Issue number	5
DOIs	https://doi.org/10.3346/jkms.2009.24.5.941
Publication status	Published - 2009 Oct
Externally published	Yes

Keywords

Alcohols
Transforming growth factor beta1

ASJC Scopus subject areas

Medicine(all)

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10.3346/jkms.2009.24.5.941

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title = "Increased transforming growth factor-beta1 in alcohol dependence",

abstract = "Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-β1) expression in animal studies. TGF-β1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-β1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-β1 levels in the patients with alcohol dependence (1,653.11 ±532.45 pg/mL) were significantly higher than those of healthy subjects (669.87 ±366.53 pg/mL) (P=0.000). Patients with or without liver pathology showed no difference in TGF-β1 (P=0.36). Increased TGF-β1 may mediate deleterious effect of alcohol such as hepatic fibrosis and suppressed neuronal developments in alcohol dependence patients.",

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AU - Kim, Yong Ku

AU - Lee, Boung Chul

AU - Ham, Byung Joo

AU - Yang, Byung Hwan

AU - Roh, Sungwon

AU - Choi, Joonho

AU - Kang, Tae Cheon

AU - Chai, Young Gyu

AU - Choi, Ihn Geun

PY - 2009/10

Y1 - 2009/10

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AB - Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-β1) expression in animal studies. TGF-β1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-β1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-β1 levels in the patients with alcohol dependence (1,653.11 ±532.45 pg/mL) were significantly higher than those of healthy subjects (669.87 ±366.53 pg/mL) (P=0.000). Patients with or without liver pathology showed no difference in TGF-β1 (P=0.36). Increased TGF-β1 may mediate deleterious effect of alcohol such as hepatic fibrosis and suppressed neuronal developments in alcohol dependence patients.

KW - Alcohols

KW - Transforming growth factor beta1

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IS - 5

ER -

Increased transforming growth factor-beta1 in alcohol dependence

Abstract

Keywords

ASJC Scopus subject areas

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