Increased transforming growth factor-beta1 in alcohol dependence

Yong Ku Kim, Boung Chul Lee, Byung-Joo Ham, Byung Hwan Yang, Sungwon Roh, Joonho Choi, Tae Cheon Kang, Young Gyu Chai, Ihn Geun Choi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-β1) expression in animal studies. TGF-β1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-β1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-β1 levels in the patients with alcohol dependence (1,653.11 ±532.45 pg/mL) were significantly higher than those of healthy subjects (669.87 ±366.53 pg/mL) (P=0.000). Patients with or without liver pathology showed no difference in TGF-β1 (P=0.36). Increased TGF-β1 may mediate deleterious effect of alcohol such as hepatic fibrosis and suppressed neuronal developments in alcohol dependence patients.

Original languageEnglish
Pages (from-to)941-944
Number of pages4
JournalJournal of Korean Medical Science
Volume24
Issue number5
DOIs
Publication statusPublished - 2009 Oct 1

Fingerprint

Transforming Growth Factor beta1
Alcoholism
Liver
Hepatic Stellate Cells
Acetaldehyde
Neuroglia
Healthy Volunteers
Fibrosis
Ethanol
Enzyme-Linked Immunosorbent Assay
Alcohols
Pathology

Keywords

  • Alcohols
  • Transforming growth factor beta1

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Increased transforming growth factor-beta1 in alcohol dependence. / Kim, Yong Ku; Lee, Boung Chul; Ham, Byung-Joo; Yang, Byung Hwan; Roh, Sungwon; Choi, Joonho; Kang, Tae Cheon; Chai, Young Gyu; Choi, Ihn Geun.

In: Journal of Korean Medical Science, Vol. 24, No. 5, 01.10.2009, p. 941-944.

Research output: Contribution to journalArticle

Kim, YK, Lee, BC, Ham, B-J, Yang, BH, Roh, S, Choi, J, Kang, TC, Chai, YG & Choi, IG 2009, 'Increased transforming growth factor-beta1 in alcohol dependence', Journal of Korean Medical Science, vol. 24, no. 5, pp. 941-944. https://doi.org/10.3346/jkms.2009.24.5.941
Kim, Yong Ku ; Lee, Boung Chul ; Ham, Byung-Joo ; Yang, Byung Hwan ; Roh, Sungwon ; Choi, Joonho ; Kang, Tae Cheon ; Chai, Young Gyu ; Choi, Ihn Geun. / Increased transforming growth factor-beta1 in alcohol dependence. In: Journal of Korean Medical Science. 2009 ; Vol. 24, No. 5. pp. 941-944.
@article{0f86872b8b4f4f4ea0fa0ea243924811,
title = "Increased transforming growth factor-beta1 in alcohol dependence",
abstract = "Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-β1) expression in animal studies. TGF-β1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-β1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-β1 levels in the patients with alcohol dependence (1,653.11 ±532.45 pg/mL) were significantly higher than those of healthy subjects (669.87 ±366.53 pg/mL) (P=0.000). Patients with or without liver pathology showed no difference in TGF-β1 (P=0.36). Increased TGF-β1 may mediate deleterious effect of alcohol such as hepatic fibrosis and suppressed neuronal developments in alcohol dependence patients.",
keywords = "Alcohols, Transforming growth factor beta1",
author = "Kim, {Yong Ku} and Lee, {Boung Chul} and Byung-Joo Ham and Yang, {Byung Hwan} and Sungwon Roh and Joonho Choi and Kang, {Tae Cheon} and Chai, {Young Gyu} and Choi, {Ihn Geun}",
year = "2009",
month = "10",
day = "1",
doi = "10.3346/jkms.2009.24.5.941",
language = "English",
volume = "24",
pages = "941--944",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "5",

}

TY - JOUR

T1 - Increased transforming growth factor-beta1 in alcohol dependence

AU - Kim, Yong Ku

AU - Lee, Boung Chul

AU - Ham, Byung-Joo

AU - Yang, Byung Hwan

AU - Roh, Sungwon

AU - Choi, Joonho

AU - Kang, Tae Cheon

AU - Chai, Young Gyu

AU - Choi, Ihn Geun

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-β1) expression in animal studies. TGF-β1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-β1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-β1 levels in the patients with alcohol dependence (1,653.11 ±532.45 pg/mL) were significantly higher than those of healthy subjects (669.87 ±366.53 pg/mL) (P=0.000). Patients with or without liver pathology showed no difference in TGF-β1 (P=0.36). Increased TGF-β1 may mediate deleterious effect of alcohol such as hepatic fibrosis and suppressed neuronal developments in alcohol dependence patients.

AB - Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-β1) expression in animal studies. TGF-β1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-β1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-β1 levels in the patients with alcohol dependence (1,653.11 ±532.45 pg/mL) were significantly higher than those of healthy subjects (669.87 ±366.53 pg/mL) (P=0.000). Patients with or without liver pathology showed no difference in TGF-β1 (P=0.36). Increased TGF-β1 may mediate deleterious effect of alcohol such as hepatic fibrosis and suppressed neuronal developments in alcohol dependence patients.

KW - Alcohols

KW - Transforming growth factor beta1

UR - http://www.scopus.com/inward/record.url?scp=75349108219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75349108219&partnerID=8YFLogxK

U2 - 10.3346/jkms.2009.24.5.941

DO - 10.3346/jkms.2009.24.5.941

M3 - Article

VL - 24

SP - 941

EP - 944

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 5

ER -