Increased transforming growth factor-beta1 in alcohol dependence

Yong Ku Kim, Boung Chul Lee, Byung-Joo Ham, Byung Hwan Yang, Sungwon Roh, Joonho Choi, Tae Cheon Kang, Young Gyu Chai, Ihn Geun Choi

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Abstract

Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-β1) expression in animal studies. TGF-β1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-β1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-β1 levels in the patients with alcohol dependence (1,653.11 ±532.45 pg/mL) were significantly higher than those of healthy subjects (669.87 ±366.53 pg/mL) (P=0.000). Patients with or without liver pathology showed no difference in TGF-β1 (P=0.36). Increased TGF-β1 may mediate deleterious effect of alcohol such as hepatic fibrosis and suppressed neuronal developments in alcohol dependence patients.

Original languageEnglish
Pages (from-to)941-944
Number of pages4
JournalJournal of Korean Medical Science
Volume24
Issue number5
DOIs
Publication statusPublished - 2009 Oct 1

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Keywords

  • Alcohols
  • Transforming growth factor beta1

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kim, Y. K., Lee, B. C., Ham, B-J., Yang, B. H., Roh, S., Choi, J., Kang, T. C., Chai, Y. G., & Choi, I. G. (2009). Increased transforming growth factor-beta1 in alcohol dependence. Journal of Korean Medical Science, 24(5), 941-944. https://doi.org/10.3346/jkms.2009.24.5.941