Increases in spinal vasoactive intestinal polypeptide and neuropeptide Y are not sufficient for the genesis of neuropathic pain in rats

Hee Jin Kim; Seung Keun Back; Junesun Kim; Backil Sung; Seung Kil Hong; Heung Sik Na

doi:10.1016/S0304-3940(03)00254-4

Increases in spinal vasoactive intestinal polypeptide and neuropeptide Y are not sufficient for the genesis of neuropathic pain in rats

Hee Jin Kim, Seung Keun Back, Junesun Kim, Backil Sung, Seung Kil Hong, Heung Sik Na

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We tested the hypothesis that increases in the spinal levels of vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) were related to the development of neuropathic pain. To this aim, we compared two groups of rats. One group showed well-developed neuropathic pain in the tail following unilateral transection of the inferior and superior caudal trunks between the S1 and S2 spinal nerves, and the other group showed poorly-developed neuropathic pain despite the same nerve injury. The increases in immunoreactivity of VIP and NPY in the S1 dorsal horn (injured segment) were not significantly different between the two groups. These results suggested that increases in the spinal levels of VIP and NPY after peripheral nerve injury were not sufficient for the development of neuropathic pain.

Original language	English
Pages (from-to)	109-113
Number of pages	5
Journal	Neuroscience Letters
Volume	342
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-3940(03)00254-4
Publication status	Published - 2003 May 15

Keywords

Allodynia
Dorsal horn
Neuropathic pain
Neuropeptide Y
Peripheral neuropathy
Vasoactive polypeptide

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(03)00254-4

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title = "Increases in spinal vasoactive intestinal polypeptide and neuropeptide Y are not sufficient for the genesis of neuropathic pain in rats",

abstract = "We tested the hypothesis that increases in the spinal levels of vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) were related to the development of neuropathic pain. To this aim, we compared two groups of rats. One group showed well-developed neuropathic pain in the tail following unilateral transection of the inferior and superior caudal trunks between the S1 and S2 spinal nerves, and the other group showed poorly-developed neuropathic pain despite the same nerve injury. The increases in immunoreactivity of VIP and NPY in the S1 dorsal horn (injured segment) were not significantly different between the two groups. These results suggested that increases in the spinal levels of VIP and NPY after peripheral nerve injury were not sufficient for the development of neuropathic pain.",

keywords = "Allodynia, Dorsal horn, Neuropathic pain, Neuropeptide Y, Peripheral neuropathy, Vasoactive polypeptide",

author = "Kim, {Hee Jin} and Back, {Seung Keun} and Junesun Kim and Backil Sung and Hong, {Seung Kil} and Na, {Heung Sik}",

note = "Funding Information: This study was supported by Brain Korea 21 Project in 2002, the Ministry of Education and a grant of the Ministry of Health and Welfare (01-PJ8-PG3-21302-0004).",

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doi = "10.1016/S0304-3940(03)00254-4",

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AU - Kim, Hee Jin

AU - Back, Seung Keun

AU - Kim, Junesun

AU - Sung, Backil

AU - Hong, Seung Kil

AU - Na, Heung Sik

N1 - Funding Information: This study was supported by Brain Korea 21 Project in 2002, the Ministry of Education and a grant of the Ministry of Health and Welfare (01-PJ8-PG3-21302-0004).

PY - 2003/5/15

Y1 - 2003/5/15

N2 - We tested the hypothesis that increases in the spinal levels of vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) were related to the development of neuropathic pain. To this aim, we compared two groups of rats. One group showed well-developed neuropathic pain in the tail following unilateral transection of the inferior and superior caudal trunks between the S1 and S2 spinal nerves, and the other group showed poorly-developed neuropathic pain despite the same nerve injury. The increases in immunoreactivity of VIP and NPY in the S1 dorsal horn (injured segment) were not significantly different between the two groups. These results suggested that increases in the spinal levels of VIP and NPY after peripheral nerve injury were not sufficient for the development of neuropathic pain.

AB - We tested the hypothesis that increases in the spinal levels of vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) were related to the development of neuropathic pain. To this aim, we compared two groups of rats. One group showed well-developed neuropathic pain in the tail following unilateral transection of the inferior and superior caudal trunks between the S1 and S2 spinal nerves, and the other group showed poorly-developed neuropathic pain despite the same nerve injury. The increases in immunoreactivity of VIP and NPY in the S1 dorsal horn (injured segment) were not significantly different between the two groups. These results suggested that increases in the spinal levels of VIP and NPY after peripheral nerve injury were not sufficient for the development of neuropathic pain.

KW - Allodynia

KW - Dorsal horn

KW - Neuropathic pain

KW - Neuropeptide Y

KW - Peripheral neuropathy

KW - Vasoactive polypeptide

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U2 - 10.1016/S0304-3940(03)00254-4

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M3 - Article

C2 - 12727330

AN - SCOPUS:0037448109

SN - 0304-3940

VL - 342

SP - 109

EP - 113

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

Increases in spinal vasoactive intestinal polypeptide and neuropeptide Y are not sufficient for the genesis of neuropathic pain in rats

Abstract

Keywords

ASJC Scopus subject areas

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