Increasing risk of uterine cervical cancer among young Japanese women

Comparison of incidence trends in Japan, South Korea and Japanese-Americans between 1985 and 2012

Mai Utada, Pavel Chernyavskiy, Won Jin Lee, Silvia Franceschi, Catherine Sauvaget, Amy Berrington de Gonzalez, Diana R. Withrow

Research output: Contribution to journalArticle

Abstract

In Japan, cervical cancer incidence has increased since the late 1990s especially among young women, despite a decreasing trend in most developed countries. Here, we examined age, period and birth cohort trends in cervical cancer incidence rates from 1985 to 2012. Incidence rates were ascertained using three population-based cancer registries and analyzed using Joinpoint regression and age-period-cohort models. We compared the findings in Japan to trends among Japanese-Americans in the Surveillance, Epidemiology, and End Results Registries and among women in South Korea using the Korea Central Registry. Age-standardized incidence rates in Japan decreased by 1.7% per year (95% confidence interval − 3.3%, 0.0%) until 1997 and thereafter increased by 2.6% per year (1.1%, 4.2%). Incidence rates increased among women under age 50, were stable among women aged 50–54, and decreased or remained stable among women aged 55 and over. The age-standardized incidence rate ratio by birth cohort showed a U-shaped pattern with the lowest rates in women born in the late 1930s and 1940s. In comparison, women born before 1920 and after 1970 had about double the incidence. Increasing risk in recent birth cohorts was not evident in Japanese-American or South Korean women. The trends in Japan may be attributable to increasing prevalence of human papillomavirus (HPV) infection among young women. Screening and vaccination have been shown to be highly effective and would help reverse these trends.

Original languageEnglish
Pages (from-to)2144-2152
Number of pages9
JournalInternational Journal of Cancer
Volume144
Issue number9
DOIs
Publication statusPublished - 2019 May 1

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Republic of Korea
Asian Americans
Uterine Cervical Neoplasms
Japan
Incidence
Registries
Parturition
Papillomavirus Infections
Birth Rate
Korea
Developed Countries
Vaccination
Epidemiology
Confidence Intervals

Keywords

  • cervical cancer
  • incidence trend
  • Japan

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Increasing risk of uterine cervical cancer among young Japanese women : Comparison of incidence trends in Japan, South Korea and Japanese-Americans between 1985 and 2012. / Utada, Mai; Chernyavskiy, Pavel; Lee, Won Jin; Franceschi, Silvia; Sauvaget, Catherine; de Gonzalez, Amy Berrington; Withrow, Diana R.

In: International Journal of Cancer, Vol. 144, No. 9, 01.05.2019, p. 2144-2152.

Research output: Contribution to journalArticle

Utada, Mai ; Chernyavskiy, Pavel ; Lee, Won Jin ; Franceschi, Silvia ; Sauvaget, Catherine ; de Gonzalez, Amy Berrington ; Withrow, Diana R. / Increasing risk of uterine cervical cancer among young Japanese women : Comparison of incidence trends in Japan, South Korea and Japanese-Americans between 1985 and 2012. In: International Journal of Cancer. 2019 ; Vol. 144, No. 9. pp. 2144-2152.
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