Indeterminate pulmonary nodules in rectal cancer: A recommendation for follow-up guidelines

Se-Jin Baek, Seon Hahn Kim, Jung-Myun Kwak, Jae Sung Cho, Jae Won Shin, Azali Hafiz Yafee Amar, Jin Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background Incidental visualization of indeterminate pulmonary nodules is considered a clinical dilemma. Methods We identified patients for inclusion in this study by searching for the term "indeterminate nodules" in the radiology database of rectal cancer patients who underwent surgery. Patients with definite metastatic disease were excluded. Results In total, 224 patients underwent chest computerized tomography (CT) and 59 of these patients had indeterminate pulmonary nodules detected more than twice by CT scan. Six patients (10.2%) were confirmed to have metastatic lesions on follow-up evaluation. Pulmonary nodule size (Pa=0.028), pathologic N status (Pa=0.049), positive nodal status (Pa=0.036) and the number of positive lymph nodes (Pa=0.033) were significant risk factors for pulmonary metastasis. In the pulmonary metastasis group, the patients who had received adjuvant oxaliplatin-based (FOLFOX4) chemotherapy had longer intervals to developing metastasis compared to patients who had not received it. Conclusions It is not necessary to perform excessive surveillance routinely for all rectal cancer patients who have indeterminate pulmonary lesions. Intensive follow-up chest CT or other invasive diagnostic modalities should be considered only in patients with pulmonary nodules larger than 5.7 mm or positive nodal status. In addition, patients receiving adjuvant FOLFOX4 chemotherapy should be followed-up for longer periods. J. Surg. Oncol. 2012; 106:481-485. © 2012 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)481-485
Number of pages5
JournalJournal of Surgical Oncology
Volume106
Issue number4
DOIs
Publication statusPublished - 2012 Sep 15

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Rectal Neoplasms
Guidelines
Lung
oxaliplatin
Tomography
Neoplasm Metastasis
Thorax
Adjuvant Chemotherapy
Radiology
Lymph Nodes
Databases
Drug Therapy

Keywords

  • computed tomography (CT)
  • indeterminate nodule
  • lung metastasis
  • lung nodule
  • rectal neoplasms

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Indeterminate pulmonary nodules in rectal cancer : A recommendation for follow-up guidelines. / Baek, Se-Jin; Kim, Seon Hahn; Kwak, Jung-Myun; Cho, Jae Sung; Shin, Jae Won; Amar, Azali Hafiz Yafee; Kim, Jin.

In: Journal of Surgical Oncology, Vol. 106, No. 4, 15.09.2012, p. 481-485.

Research output: Contribution to journalArticle

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N2 - Background Incidental visualization of indeterminate pulmonary nodules is considered a clinical dilemma. Methods We identified patients for inclusion in this study by searching for the term "indeterminate nodules" in the radiology database of rectal cancer patients who underwent surgery. Patients with definite metastatic disease were excluded. Results In total, 224 patients underwent chest computerized tomography (CT) and 59 of these patients had indeterminate pulmonary nodules detected more than twice by CT scan. Six patients (10.2%) were confirmed to have metastatic lesions on follow-up evaluation. Pulmonary nodule size (Pa=0.028), pathologic N status (Pa=0.049), positive nodal status (Pa=0.036) and the number of positive lymph nodes (Pa=0.033) were significant risk factors for pulmonary metastasis. In the pulmonary metastasis group, the patients who had received adjuvant oxaliplatin-based (FOLFOX4) chemotherapy had longer intervals to developing metastasis compared to patients who had not received it. Conclusions It is not necessary to perform excessive surveillance routinely for all rectal cancer patients who have indeterminate pulmonary lesions. Intensive follow-up chest CT or other invasive diagnostic modalities should be considered only in patients with pulmonary nodules larger than 5.7 mm or positive nodal status. In addition, patients receiving adjuvant FOLFOX4 chemotherapy should be followed-up for longer periods. J. Surg. Oncol. 2012; 106:481-485. © 2012 Wiley Periodicals, Inc.

AB - Background Incidental visualization of indeterminate pulmonary nodules is considered a clinical dilemma. Methods We identified patients for inclusion in this study by searching for the term "indeterminate nodules" in the radiology database of rectal cancer patients who underwent surgery. Patients with definite metastatic disease were excluded. Results In total, 224 patients underwent chest computerized tomography (CT) and 59 of these patients had indeterminate pulmonary nodules detected more than twice by CT scan. Six patients (10.2%) were confirmed to have metastatic lesions on follow-up evaluation. Pulmonary nodule size (Pa=0.028), pathologic N status (Pa=0.049), positive nodal status (Pa=0.036) and the number of positive lymph nodes (Pa=0.033) were significant risk factors for pulmonary metastasis. In the pulmonary metastasis group, the patients who had received adjuvant oxaliplatin-based (FOLFOX4) chemotherapy had longer intervals to developing metastasis compared to patients who had not received it. Conclusions It is not necessary to perform excessive surveillance routinely for all rectal cancer patients who have indeterminate pulmonary lesions. Intensive follow-up chest CT or other invasive diagnostic modalities should be considered only in patients with pulmonary nodules larger than 5.7 mm or positive nodal status. In addition, patients receiving adjuvant FOLFOX4 chemotherapy should be followed-up for longer periods. J. Surg. Oncol. 2012; 106:481-485. © 2012 Wiley Periodicals, Inc.

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