Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats

Kwang Kim Sun; Byung Il Min; Hoon Kim Ji; Gil Hwang Byung; Yong Yoo Gi; Suk Park Dong; Sik Na Heung

doi:10.1016/j.ejphar.2005.08.030

Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats

Kwang Kim Sun, Byung Il Min, Hoon Kim Ji, Gil Hwang Byung, Yong Yoo Gi, Suk Park Dong, Sik Na Heung

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

In neuropathic rats sensitive to phentolamine (α-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (α₁-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (α₂-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the α-adrenoreceptor subtype predominantly involved in cold allodynia.

Original language	English
Pages (from-to)	64-66
Number of pages	3
Journal	European Journal of Pharmacology
Volume	523
Issue number	1-3
DOIs	https://doi.org/10.1016/j.ejphar.2005.08.030
Publication status	Published - 2005 Oct 31

Keywords

Cold allodynia
Neuropathic pain
Phentolamine
Prazosin
Yohimbine
α-adrenoreceptor

ASJC Scopus subject areas

Pharmacology

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10.1016/j.ejphar.2005.08.030

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title = "Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats",

abstract = "In neuropathic rats sensitive to phentolamine (α-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (α1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (α2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the α-adrenoreceptor subtype predominantly involved in cold allodynia.",

keywords = "Cold allodynia, Neuropathic pain, Phentolamine, Prazosin, Yohimbine, α-adrenoreceptor",

author = "Sun, {Kwang Kim} and Min, {Byung Il} and Ji, {Hoon Kim} and Byung, {Gil Hwang} and Gi, {Yong Yoo} and Dong, {Suk Park} and Heung, {Sik Na}",

year = "2005",

month = oct,

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journal = "European Journal of Pharmacology",

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T1 - Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats

AU - Sun, Kwang Kim

AU - Min, Byung Il

AU - Ji, Hoon Kim

AU - Byung, Gil Hwang

AU - Gi, Yong Yoo

AU - Dong, Suk Park

AU - Heung, Sik Na

PY - 2005/10/31

Y1 - 2005/10/31

N2 - In neuropathic rats sensitive to phentolamine (α-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (α1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (α2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the α-adrenoreceptor subtype predominantly involved in cold allodynia.

AB - In neuropathic rats sensitive to phentolamine (α-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (α1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (α2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the α-adrenoreceptor subtype predominantly involved in cold allodynia.

KW - Cold allodynia

KW - Neuropathic pain

KW - Phentolamine

KW - Prazosin

KW - Yohimbine

KW - α-adrenoreceptor

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