Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats

Kwang Kim Sun, Byung Il Min, Hoon Kim Ji, Gil Hwang Byung, Yong Yoo Gi, Suk Park Dong, Sik Na Heung

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

In neuropathic rats sensitive to phentolamine (α-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (α1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (α2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the α-adrenoreceptor subtype predominantly involved in cold allodynia.

Original languageEnglish
Pages (from-to)64-66
Number of pages3
JournalEuropean Journal of Pharmacology
Volume523
Issue number1-3
DOIs
Publication statusPublished - 2005 Oct 31

Keywords

  • Cold allodynia
  • Neuropathic pain
  • Phentolamine
  • Prazosin
  • Yohimbine
  • α-adrenoreceptor

ASJC Scopus subject areas

  • Pharmacology

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