Abstract
In neuropathic rats sensitive to phentolamine (α-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (α1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (α2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the α-adrenoreceptor subtype predominantly involved in cold allodynia.
| Original language | English |
|---|---|
| Pages (from-to) | 64-66 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 523 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 2005 Oct 31 |
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ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. / Sun, Kwang Kim; Min, Byung I.; Ji, Hoon Kim; Byung, Gil Hwang; Gi, Yong Yoo; Dong, Suk Park; Na, Heung Sik.
In: European Journal of Pharmacology, Vol. 523, No. 1-3, 31.10.2005, p. 64-66.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats
AU - Sun, Kwang Kim
AU - Min, Byung I.
AU - Ji, Hoon Kim
AU - Byung, Gil Hwang
AU - Gi, Yong Yoo
AU - Dong, Suk Park
AU - Na, Heung Sik
PY - 2005/10/31
Y1 - 2005/10/31
N2 - In neuropathic rats sensitive to phentolamine (α-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (α1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (α2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the α-adrenoreceptor subtype predominantly involved in cold allodynia.
AB - In neuropathic rats sensitive to phentolamine (α-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (α1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (α2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the α-adrenoreceptor subtype predominantly involved in cold allodynia.
KW - α-adrenoreceptor
KW - Cold allodynia
KW - Neuropathic pain
KW - Phentolamine
KW - Prazosin
KW - Yohimbine
UR - http://www.scopus.com/inward/record.url?scp=27644589737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27644589737&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2005.08.030
DO - 10.1016/j.ejphar.2005.08.030
M3 - Article
C2 - 16226740
AN - SCOPUS:27644589737
VL - 523
SP - 64
EP - 66
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1-3
ER -