Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats

Kwang Kim Sun, Byung I. Min, Hoon Kim Ji, Gil Hwang Byung, Yong Yoo Gi, Suk Park Dong, Heung Sik Na

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In neuropathic rats sensitive to phentolamine (α-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (α1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (α2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the α-adrenoreceptor subtype predominantly involved in cold allodynia.

Original languageEnglish
Pages (from-to)64-66
Number of pages3
JournalEuropean Journal of Pharmacology
Volume523
Issue number1-3
DOIs
Publication statusPublished - 2005 Oct 31

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Phentolamine
Hyperalgesia
Individuality
Yohimbine
Prazosin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. / Sun, Kwang Kim; Min, Byung I.; Ji, Hoon Kim; Byung, Gil Hwang; Gi, Yong Yoo; Dong, Suk Park; Na, Heung Sik.

In: European Journal of Pharmacology, Vol. 523, No. 1-3, 31.10.2005, p. 64-66.

Research output: Contribution to journalArticle

Sun, Kwang Kim ; Min, Byung I. ; Ji, Hoon Kim ; Byung, Gil Hwang ; Gi, Yong Yoo ; Dong, Suk Park ; Na, Heung Sik. / Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. In: European Journal of Pharmacology. 2005 ; Vol. 523, No. 1-3. pp. 64-66.
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AU - Dong, Suk Park

AU - Na, Heung Sik

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