Abstract
In neuropathic rats sensitive to phentolamine (α-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (α1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (α2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the α-adrenoreceptor subtype predominantly involved in cold allodynia.
| Original language | English |
|---|---|
| Pages (from-to) | 64-66 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 523 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 2005 Oct 31 |
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
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Cite this
Sun, K. K., Min, B. I., Ji, H. K., Byung, G. H., Gi, Y. Y., Dong, S. P., & Na, H. S. (2005). Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. European Journal of Pharmacology, 523(1-3), 64-66. https://doi.org/10.1016/j.ejphar.2005.08.030