Indomethacin treatment decreases renal blood flow velocity in human neonates

Nam Soo Kang, Kee Hwan Yoo, Haewon Cheon, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

This study was designed to evaluate the effect of indomethacin (ID) on renal perfusion in 13 neonates with symptomatic patent ductus arteriosus (PDA). Serial blood flow velocity in the left renal artery was measured just before and at 10, 30, 45, 60, 75 and 90 min after ID administration. Serum creatinine (Cr), sodium (Na), and osmolarity were measured just before, at 12 and 24 h, and at 3 days after ID administration. Timed urine also was collected for measurement of amount, fractional excretion of Na (FE(Na)), and creatinine clearance (C(Cr)). ID decreased end-diastolic flow velocity of renal artery and increased Pourcelot's index, starting at 10 min and lasting for 75 min (p < 0.05). Serum Cr significantly increased at 12 h, and hourly urine output and C(Cr) decreased for 24 h. Serum Na and osmolarity decreased for a period of at least 3 days (p < 0.05). FE(Na) decreased at 12-24 h (p < 0.05). We conclude that ID treatment can induce significant renal dysfunction due to diminution of renal perfusion in human neonates.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalBiology of the Neonate
Volume76
Issue number5
DOIs
Publication statusPublished - 1999 Nov 1

Fingerprint

Blood Flow Velocity
Renal Circulation
Indomethacin
Creatinine
Renal Artery
Kidney
Osmolar Concentration
Perfusion
Serum
Urine
Patent Ductus Arteriosus
Sodium

Keywords

  • Indomethacin
  • Neonates
  • Patent ductus arteriosus
  • Renal dysfunction

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Indomethacin treatment decreases renal blood flow velocity in human neonates. / Kang, Nam Soo; Yoo, Kee Hwan; Cheon, Haewon; Choi, Byung Min; Hong, Young Sook; Lee, Joo Won; Kim, Soon Kyum.

In: Biology of the Neonate, Vol. 76, No. 5, 01.11.1999, p. 261-265.

Research output: Contribution to journalArticle

Kang, Nam Soo ; Yoo, Kee Hwan ; Cheon, Haewon ; Choi, Byung Min ; Hong, Young Sook ; Lee, Joo Won ; Kim, Soon Kyum. / Indomethacin treatment decreases renal blood flow velocity in human neonates. In: Biology of the Neonate. 1999 ; Vol. 76, No. 5. pp. 261-265.
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