Induced neural stem cells as a means of treatment in Huntington’s disease

Kyung Ah Choi, Sunghoi Hong

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Introduction: Huntington’s disease (HD) is an inherited neurodegenerative disease characterized by chorea, dementia, and depression caused by progressive nerve cell degeneration, which is triggered by expanded CAG repeats in the huntingtin (Htt) gene. Currently, there is no cure for this disease, nor is there an effective medicine available to delay or improve the physical, mental, and behavioral severities caused by it. Areas covered: In this review, the authors describe the use of induced neural stem cells (iNSCs) by direct conversion technology, which offers great advantages as a therapeutic cell type to treat HD. Expert opinion: Cell conversion of somatic cells into a desired stem cell type is one of the most promising treatments for HD because it could be facilitated for the generation of patient-specific neural stem cells. The induced pluripotent stem cells (iPSCs) have a powerful potential for differentiation into neurons, but they may cause teratoma formation due to an undifferentiated pluripotent stem cell after transplantation Therefore, direct conversion of somatic cells into iNSCs is a promising alternative technology in regenerative medicine and the iNSCs may be provided as a therapeutic cell source for Huntington’s disease.

Original languageEnglish
Pages (from-to)1333-1343
Number of pages11
JournalExpert Opinion on Biological Therapy
Volume17
Issue number11
DOIs
Publication statusPublished - 2017 Nov 2

Keywords

  • cell conversion
  • Huntington’s diseases
  • Induced neural stem cells
  • stem cell therapy

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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