Induction of CITED2 expression in the rat hippocampus following transient global ischemia

Woong Sun, Kye Hyun Kim, Mira Noh, Soontaek Hong, Pil Woo Huh, Younghwa Kim, Hyun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

CITED2 is implicated in the modulating the activity of HIF-1 which is a major transcription factor involved in ischemia-related gene expression. Following transient forebrain ischemia, we found that CITED2 was induced in a subset of brain regions including dentate gyrus of the hippocampal formation and piriform cortex. Because CITED2 was not induced in cultured neurons exposed to oxygen-glucose deprivation, we concluded that hypoxia is not sufficient to trigger its induction.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalBrain Research
Volume1072
Issue number1
DOIs
Publication statusPublished - 2006 Feb 9

Keywords

  • CITED2
  • Dentate gyrus
  • Gene expression
  • HIF-1
  • Transient forebrain ischemia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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