Induction of ezrin-radixin-moesin molecules after cryogenic traumatic brain injury of the mouse cortex

Younghye Moon, Joo Yeon Kim, So Yoen Choi, Kyungjin Kim, Hyun Kim, Woong Sun

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Traumatic brain injury promotes rapid induction of microglial cells and infiltration of peripheral macrophages to the injury sites. Such inflammatory responses are mediated by the activation and migration of immune cells, which are influenced by the actin cytoskeleton remodeling. In this study, we observed that the phosphorylation and expressions of ezrin-radixin-moesin (ERM) proteins, which are linkers for cell surface with actin cytoskeleton, are induced in the activated microglia/macrophages, whereas ERM molecules are only marginally expressed in quiescent microglia in the normal brain. These results suggest that ERM activation in the injury penumbra is implicated in the inflammatory immune responses after traumatic brain injury.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalNeuroreport
Volume22
Issue number6
DOIs
Publication statusPublished - 2011 Apr 20

Keywords

  • Ezrin-radixin-moesin
  • macrophage
  • microglia
  • traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)

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