Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation

In Duk Jung, Jun Sik Lee, Chang Min Lee, Kyung Tae Noh, Yeong Il Jeong, Won Sun Park, Sung Hak Chun, Soo Kyung Jeong, Jin Wook Park, Kwang Hee Son, Deok Rim Heo, Min-Goo Lee, Yong Kyoo Shin, Han Wool Kim, Cheol Heui Yun, Yeong Min Park

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Heme oxygenase (HO)-1 is expressed in a variety of conditions involved in the regulation of immune responses. In this study, we examined the role of HO-1 in dendritic cell (DC) maturation and expression of indoleamine 2,3-dioxygenase (IDO), a key enzyme that catalyzes the initial, rate-limiting step in tryptophan degradation. IDO deficiency led to diminished phenotypic and functional maturation of DCs in vitro and in vivo. IDO expression and DC maturation was abrogated by the HO inhibitor zinc protoporphrin, but increased by hemin, a potent inducer of HO-1. Moreover, LPS-induced HO-1 expression was mediated by an NF-κB-dependent pathway. Our findings provide additional insight into the immunological functions of IDO and HO-1, and suggest possible therapeutic adjuvants for the treatment of DC-related acute and chronic diseases.

Original languageEnglish
Pages (from-to)491-505
Number of pages15
JournalBiochemical Pharmacology
Volume80
Issue number4
DOIs
Publication statusPublished - 2010 Aug 1

Fingerprint

Indoleamine-Pyrrole 2,3,-Dioxygenase
Heme Oxygenase-1
Dendritic Cells
Heme Oxygenase (Decyclizing)
Hemin
Acute Disease
Tryptophan
Zinc
Chronic Disease
Degradation
Enzymes

Keywords

  • Dendritic cells
  • Heme oxygenase
  • Indoleamine 2,3-dioxygenase
  • Lipopolysaccharide

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

Cite this

Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation. / Jung, In Duk; Lee, Jun Sik; Lee, Chang Min; Noh, Kyung Tae; Jeong, Yeong Il; Park, Won Sun; Chun, Sung Hak; Jeong, Soo Kyung; Park, Jin Wook; Son, Kwang Hee; Heo, Deok Rim; Lee, Min-Goo; Shin, Yong Kyoo; Kim, Han Wool; Yun, Cheol Heui; Park, Yeong Min.

In: Biochemical Pharmacology, Vol. 80, No. 4, 01.08.2010, p. 491-505.

Research output: Contribution to journalArticle

Jung, ID, Lee, JS, Lee, CM, Noh, KT, Jeong, YI, Park, WS, Chun, SH, Jeong, SK, Park, JW, Son, KH, Heo, DR, Lee, M-G, Shin, YK, Kim, HW, Yun, CH & Park, YM 2010, 'Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation', Biochemical Pharmacology, vol. 80, no. 4, pp. 491-505. https://doi.org/10.1016/j.bcp.2010.04.025
Jung, In Duk ; Lee, Jun Sik ; Lee, Chang Min ; Noh, Kyung Tae ; Jeong, Yeong Il ; Park, Won Sun ; Chun, Sung Hak ; Jeong, Soo Kyung ; Park, Jin Wook ; Son, Kwang Hee ; Heo, Deok Rim ; Lee, Min-Goo ; Shin, Yong Kyoo ; Kim, Han Wool ; Yun, Cheol Heui ; Park, Yeong Min. / Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation. In: Biochemical Pharmacology. 2010 ; Vol. 80, No. 4. pp. 491-505.
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