Induction of neuron-derived orphan receptor-1 in the dentate gyrus of the hippocampal formation following transient global ischemia in the rat

Younghwa Kim, Soontaek Hong, Mi Ra Noh, Soo Young Kim, Pil Woo Huh, Sun Hwa Park, Woong Sun, Hyun Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Neuron-derived orphan receptor (NOR-1) is a member of the thyroid/ steroid receptor superfamily that was originally identified in forebrain neuronal cells undergoing apoptosis. In addition to apoptotic stimuli, activation of several signal transduction pathways including direct neuronal depolarization regulates the expression of NOR-1. In this study we tested whether the expression of NOR-1 is changed following transient ischemic injury in the adult rat brain. NOR-1 mRNA increased rapidly in the dentate gyrus of the hippocampal formation and piriform cortex 3 h after transient global ischemia and returned to basal level at 6 h. On the other hand, oxygen-glucose deprivation of cultured cerebral cortical neurons did not alter the expression of NOR-1. These results suggest that expression of NOR-1 is differentially regulated in different brain regions in response to globally applied brain ischemia, but that hypoxia is not sufficient to induce its expression.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalMolecules and cells
Volume22
Issue number1
Publication statusPublished - 2006 Aug 31

Keywords

  • Depolarization
  • Hypoxia
  • NOR-1
  • OGD
  • Transient global ischemia

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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