Induction of TGF-β-inducible gene-h3 (βig-h3) by TGF-β1 in astrocytes: Implications for astrocyte response to brain injury

Su Jin Yun, Mi Ok Kim, Sung Ok Kim, Jiho Park, Yunhee K. Kwon, In San Kim, Eunjoo H. Lee

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Transforming growth factor (TGF)-β-inducible gene-h3 (βig-h3) product is a secreted protein that is induced by TGF-β in several cell types and implicated in various tissue pathologies. The aims of this study were to determine the effect of TGF-β1 on βig-h3 expression in cultured astrocytes and to examine whether βig-h3 is expressed in the brain after traumatic injury. The results showed that βig-h3 mRNA and protein increased in response to TGF-β1 in U87 human astrocytoma cells and mouse cortical astrocytes. Treatment with other cytokines, including tumor necrosis factor-α and fibroblast growth factor-2, did not enhance the expression of βig-h3 in astrocytes. βig-h3 was significantly expressed in reactive astrocytes at the site of a stab wound in the cerebral cortex of adult rats. These results provide an insight into understanding a novel role for βig-h3 protein in the response of astrocytes to brain injury.

Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalMolecular Brain Research
Volume107
Issue number1
DOIs
Publication statusPublished - 2002 Oct 30
Externally publishedYes

Keywords

  • Astrocyte
  • Brain injury
  • Gliosis
  • TGF-β1
  • Wound healing
  • βig-h3

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Induction of TGF-β-inducible gene-h3 (βig-h3) by TGF-β1 in astrocytes: Implications for astrocyte response to brain injury'. Together they form a unique fingerprint.

Cite this