Induction of TGF-β-inducible gene-h3 (βig-h3) by TGF-β1 in astrocytes: Implications for astrocyte response to brain injury

Su Jin Yun, Mi Ok Kim, Sung Ok Kim, Jiho Park, Yunhee K. Kwon, In-San Kim, Eunjoo H. Lee

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Transforming growth factor (TGF)-β-inducible gene-h3 (βig-h3) product is a secreted protein that is induced by TGF-β in several cell types and implicated in various tissue pathologies. The aims of this study were to determine the effect of TGF-β1 on βig-h3 expression in cultured astrocytes and to examine whether βig-h3 is expressed in the brain after traumatic injury. The results showed that βig-h3 mRNA and protein increased in response to TGF-β1 in U87 human astrocytoma cells and mouse cortical astrocytes. Treatment with other cytokines, including tumor necrosis factor-α and fibroblast growth factor-2, did not enhance the expression of βig-h3 in astrocytes. βig-h3 was significantly expressed in reactive astrocytes at the site of a stab wound in the cerebral cortex of adult rats. These results provide an insight into understanding a novel role for βig-h3 protein in the response of astrocytes to brain injury.

Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalMolecular Brain Research
Volume107
Issue number1
DOIs
Publication statusPublished - 2002 Oct 30
Externally publishedYes

Fingerprint

Transforming Growth Factors
Astrocytes
Brain Injuries
Genes
Stab Wounds
Gene Expression
Proteins
Astrocytoma
Fibroblast Growth Factor 2
Cerebral Cortex
Tumor Necrosis Factor-alpha
Pathology
Cytokines
Messenger RNA

Keywords

  • βig-h3
  • Astrocyte
  • Brain injury
  • Gliosis
  • TGF-β1
  • Wound healing

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Induction of TGF-β-inducible gene-h3 (βig-h3) by TGF-β1 in astrocytes : Implications for astrocyte response to brain injury. / Yun, Su Jin; Kim, Mi Ok; Kim, Sung Ok; Park, Jiho; Kwon, Yunhee K.; Kim, In-San; Lee, Eunjoo H.

In: Molecular Brain Research, Vol. 107, No. 1, 30.10.2002, p. 57-64.

Research output: Contribution to journalArticle

Yun, Su Jin ; Kim, Mi Ok ; Kim, Sung Ok ; Park, Jiho ; Kwon, Yunhee K. ; Kim, In-San ; Lee, Eunjoo H. / Induction of TGF-β-inducible gene-h3 (βig-h3) by TGF-β1 in astrocytes : Implications for astrocyte response to brain injury. In: Molecular Brain Research. 2002 ; Vol. 107, No. 1. pp. 57-64.
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