Infant brain atlases from neonates to 1- and 2-year-olds

Feng Shi, Pew Thian Yap, Guorong Wu, Hongjun Jia, John H. Gilmore, Weili Lin, Dinggang Shen

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Background: Studies for infants are usually hindered by the insufficient image contrast, especially for neonates. Prior knowledge, in the form of atlas, can provide additional guidance for the data processing such as spatial normalization, label propagation, and tissue segmentation. Although it is highly desired, there is currently no such infant atlas which caters for all these applications. The reason may be largely due to the dramatic early brain development, image processing difficulties, and the need of a large sample size. Methodology: To this end, after several years of subject recruitment and data acquisition, we have collected a unique longitudinal dataset, involving 95 normal infants (56 males and 39 females) with MRI scanned at 3 ages, i.e., neonate, 1-year-old, and 2-year-old. State-of-the-art MR image segmentation and registration techniques were employed, to construct which include the templates (grayscale average images), tissue probability maps (TPMs), and brain parcellation maps (i.e., meaningful anatomical regions of interest) for each age group. In addition, the longitudinal correspondences between age-specific atlases were also obtained. Experiments of typical infant applications validated that the proposed atlas outperformed other atlases and is hence very useful for infant-related studies. Conclusions: We expect that the proposed infant 0-1-2 brain atlases would be significantly conducive to structural and functional studies of the infant brains. These atlases are publicly available in our website http://bric.unc.edu/ideagroup/ free-softwares/.

Original languageEnglish
Article numbere18746
JournalPLoS One
Volume6
Issue number4
DOIs
Publication statusPublished - 2011 Apr 26
Externally publishedYes

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Atlases
Brain
neonates
Newborn Infant
brain
Tissue
Image registration
Image segmentation
Magnetic resonance imaging
Labels
Websites
Data acquisition
Image processing
image analysis
Sample Size
methodology
Software
Age Groups
Experiments
sampling

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Shi, F., Yap, P. T., Wu, G., Jia, H., Gilmore, J. H., Lin, W., & Shen, D. (2011). Infant brain atlases from neonates to 1- and 2-year-olds. PLoS One, 6(4), [e18746]. https://doi.org/10.1371/journal.pone.0018746

Infant brain atlases from neonates to 1- and 2-year-olds. / Shi, Feng; Yap, Pew Thian; Wu, Guorong; Jia, Hongjun; Gilmore, John H.; Lin, Weili; Shen, Dinggang.

In: PLoS One, Vol. 6, No. 4, e18746, 26.04.2011.

Research output: Contribution to journalArticle

Shi, F, Yap, PT, Wu, G, Jia, H, Gilmore, JH, Lin, W & Shen, D 2011, 'Infant brain atlases from neonates to 1- and 2-year-olds', PLoS One, vol. 6, no. 4, e18746. https://doi.org/10.1371/journal.pone.0018746
Shi F, Yap PT, Wu G, Jia H, Gilmore JH, Lin W et al. Infant brain atlases from neonates to 1- and 2-year-olds. PLoS One. 2011 Apr 26;6(4). e18746. https://doi.org/10.1371/journal.pone.0018746
Shi, Feng ; Yap, Pew Thian ; Wu, Guorong ; Jia, Hongjun ; Gilmore, John H. ; Lin, Weili ; Shen, Dinggang. / Infant brain atlases from neonates to 1- and 2-year-olds. In: PLoS One. 2011 ; Vol. 6, No. 4.
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