Inflammation and stem cell migration to the injured brain in higher organisms

Dong Hyuk Park, David J. Eve, James Musso, Stephen K. Klasko, Eduardo Cruz, Cesario V. Borlongan, Paul R. Sanberg

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Current treatments of neurological disorders such as Parkinson's disease and stroke are only partially effective. Consequently new therapies such as cell transplantation are of great interest. Cell therapy has shown promising results in animal models and in limited clinical trials. This form of treatment does have its own concerns, such as what factors control the survival and/or migration of the transplanted cells and how do they exert their benefit. Recent studies on tracking the transplants, such as prelabeling of the cells prior to transplant, and those elucidating the role of chemokines, as well as microglial and inflammatory responses, that may initiate the movement and survival of these cells are discussed in this review. A better understanding of these mechanism-driven pathways of neural repair will facilitate the clinical application of cell therapy for neurological disorders.

Original languageEnglish
Pages (from-to)693-701
Number of pages9
JournalStem cells and development
Volume18
Issue number5
DOIs
Publication statusPublished - 2009 Jun 1

ASJC Scopus subject areas

  • Hematology
  • Developmental Biology
  • Cell Biology

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    Park, D. H., Eve, D. J., Musso, J., Klasko, S. K., Cruz, E., Borlongan, C. V., & Sanberg, P. R. (2009). Inflammation and stem cell migration to the injured brain in higher organisms. Stem cells and development, 18(5), 693-701. https://doi.org/10.1089/scd.2009.0008