Inflammation and stem cell migration to the injured brain in higher organisms

Dong-Hyuk Park, David J. Eve, James Musso, Stephen K. Klasko, Eduardo Cruz, Cesario V. Borlongan, Paul R. Sanberg

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Current treatments of neurological disorders such as Parkinson's disease and stroke are only partially effective. Consequently new therapies such as cell transplantation are of great interest. Cell therapy has shown promising results in animal models and in limited clinical trials. This form of treatment does have its own concerns, such as what factors control the survival and/or migration of the transplanted cells and how do they exert their benefit. Recent studies on tracking the transplants, such as prelabeling of the cells prior to transplant, and those elucidating the role of chemokines, as well as microglial and inflammatory responses, that may initiate the movement and survival of these cells are discussed in this review. A better understanding of these mechanism-driven pathways of neural repair will facilitate the clinical application of cell therapy for neurological disorders.

Original languageEnglish
Pages (from-to)693-701
Number of pages9
JournalStem Cells and Development
Volume18
Issue number5
DOIs
Publication statusPublished - 2009 Jun 1

Fingerprint

Cell Movement
Stem Cells
Cell- and Tissue-Based Therapy
Inflammation
Nervous System Diseases
Brain
Transplants
Neural Pathways
Cell Transplantation
Chemokines
Parkinson Disease
Cell Survival
Therapeutics
Animal Models
Stroke
Clinical Trials

ASJC Scopus subject areas

  • Hematology
  • Developmental Biology
  • Cell Biology

Cite this

Park, D-H., Eve, D. J., Musso, J., Klasko, S. K., Cruz, E., Borlongan, C. V., & Sanberg, P. R. (2009). Inflammation and stem cell migration to the injured brain in higher organisms. Stem Cells and Development, 18(5), 693-701. https://doi.org/10.1089/scd.2009.0008

Inflammation and stem cell migration to the injured brain in higher organisms. / Park, Dong-Hyuk; Eve, David J.; Musso, James; Klasko, Stephen K.; Cruz, Eduardo; Borlongan, Cesario V.; Sanberg, Paul R.

In: Stem Cells and Development, Vol. 18, No. 5, 01.06.2009, p. 693-701.

Research output: Contribution to journalReview article

Park, D-H, Eve, DJ, Musso, J, Klasko, SK, Cruz, E, Borlongan, CV & Sanberg, PR 2009, 'Inflammation and stem cell migration to the injured brain in higher organisms', Stem Cells and Development, vol. 18, no. 5, pp. 693-701. https://doi.org/10.1089/scd.2009.0008
Park, Dong-Hyuk ; Eve, David J. ; Musso, James ; Klasko, Stephen K. ; Cruz, Eduardo ; Borlongan, Cesario V. ; Sanberg, Paul R. / Inflammation and stem cell migration to the injured brain in higher organisms. In: Stem Cells and Development. 2009 ; Vol. 18, No. 5. pp. 693-701.
@article{a42ce334194241ff8c4bdf55d2d7e7a2,
title = "Inflammation and stem cell migration to the injured brain in higher organisms",
abstract = "Current treatments of neurological disorders such as Parkinson's disease and stroke are only partially effective. Consequently new therapies such as cell transplantation are of great interest. Cell therapy has shown promising results in animal models and in limited clinical trials. This form of treatment does have its own concerns, such as what factors control the survival and/or migration of the transplanted cells and how do they exert their benefit. Recent studies on tracking the transplants, such as prelabeling of the cells prior to transplant, and those elucidating the role of chemokines, as well as microglial and inflammatory responses, that may initiate the movement and survival of these cells are discussed in this review. A better understanding of these mechanism-driven pathways of neural repair will facilitate the clinical application of cell therapy for neurological disorders.",
author = "Dong-Hyuk Park and Eve, {David J.} and James Musso and Klasko, {Stephen K.} and Eduardo Cruz and Borlongan, {Cesario V.} and Sanberg, {Paul R.}",
year = "2009",
month = "6",
day = "1",
doi = "10.1089/scd.2009.0008",
language = "English",
volume = "18",
pages = "693--701",
journal = "Journal of Hematotherapy and Stem Cell Research",
issn = "1547-3287",
publisher = "Mary Ann Liebert Inc.",
number = "5",

}

TY - JOUR

T1 - Inflammation and stem cell migration to the injured brain in higher organisms

AU - Park, Dong-Hyuk

AU - Eve, David J.

AU - Musso, James

AU - Klasko, Stephen K.

AU - Cruz, Eduardo

AU - Borlongan, Cesario V.

AU - Sanberg, Paul R.

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Current treatments of neurological disorders such as Parkinson's disease and stroke are only partially effective. Consequently new therapies such as cell transplantation are of great interest. Cell therapy has shown promising results in animal models and in limited clinical trials. This form of treatment does have its own concerns, such as what factors control the survival and/or migration of the transplanted cells and how do they exert their benefit. Recent studies on tracking the transplants, such as prelabeling of the cells prior to transplant, and those elucidating the role of chemokines, as well as microglial and inflammatory responses, that may initiate the movement and survival of these cells are discussed in this review. A better understanding of these mechanism-driven pathways of neural repair will facilitate the clinical application of cell therapy for neurological disorders.

AB - Current treatments of neurological disorders such as Parkinson's disease and stroke are only partially effective. Consequently new therapies such as cell transplantation are of great interest. Cell therapy has shown promising results in animal models and in limited clinical trials. This form of treatment does have its own concerns, such as what factors control the survival and/or migration of the transplanted cells and how do they exert their benefit. Recent studies on tracking the transplants, such as prelabeling of the cells prior to transplant, and those elucidating the role of chemokines, as well as microglial and inflammatory responses, that may initiate the movement and survival of these cells are discussed in this review. A better understanding of these mechanism-driven pathways of neural repair will facilitate the clinical application of cell therapy for neurological disorders.

UR - http://www.scopus.com/inward/record.url?scp=66249122757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66249122757&partnerID=8YFLogxK

U2 - 10.1089/scd.2009.0008

DO - 10.1089/scd.2009.0008

M3 - Review article

VL - 18

SP - 693

EP - 701

JO - Journal of Hematotherapy and Stem Cell Research

JF - Journal of Hematotherapy and Stem Cell Research

SN - 1547-3287

IS - 5

ER -