Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder

Eunsoo Won, June Kang, Aram Kim, Sunyoung Choi, Kyu Man Han, Woo Suk Tae, Hun Soo Chang, Kyu Ri Son, Tsafrir Greenberg, Sook Haeng Joe, Min-Soo Lee, Byung-Joo Ham

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We investigated the interactive effects of BclI C/G (rs41423247) allelic variants and the diagnosis of major depressive disorder (MDD) on hippocampal shape and integrity of the left parahippocampal subdivision of the cingulum. Fifty-two patients with MDD and 52 healthy controls (HCs) underwent T1-weighted structural magnetic resonance imaging and BclI C/G (rs41423247) genotyping. We analyzed hippocampal shape using the FIRST module of FSL and analyzed white matter (WM) integrity using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Significant alterations in left hippocampal shape and decreased fractional anisotropy (FA) values of the left parahippocampal cingulum were observed in MDD patients, compared to HCs. In addition, MDD patients of the BclI minor (G-) allele carrier group showed significant alterations in left hippocampal shape and decreased FA values of the left parahippocampal cingulum compared to BclI minor (G-) allele carrier HCs. No significant differences between diagnostic subgroups of the C/C homozygotes were observed. Our study provides evidence for alterations in hippocampal shape and decreased integrity of the WM region associated with the hippocampus in MDD, and for the possible influence of BclI C/G polymorphism (rs41423247) on hippocampal shape and integrity of the parahippocampal subdivision of the cingulum in depression.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalPsychoneuroendocrinology
Volume72
DOIs
Publication statusPublished - 2016 Oct 1

Fingerprint

Major Depressive Disorder
Anisotropy
Alleles
Diffusion Tensor Imaging
Homozygote
Hippocampus
Magnetic Resonance Imaging
White Matter
Depression

Keywords

  • BclI C/G (rs41423247)
  • Hippocampus
  • Major depressive disorder
  • Parahippocampal cingulum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems

Cite this

Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder. / Won, Eunsoo; Kang, June; Kim, Aram; Choi, Sunyoung; Han, Kyu Man; Tae, Woo Suk; Chang, Hun Soo; Son, Kyu Ri; Greenberg, Tsafrir; Joe, Sook Haeng; Lee, Min-Soo; Ham, Byung-Joo.

In: Psychoneuroendocrinology, Vol. 72, 01.10.2016, p. 147-155.

Research output: Contribution to journalArticle

Won, Eunsoo ; Kang, June ; Kim, Aram ; Choi, Sunyoung ; Han, Kyu Man ; Tae, Woo Suk ; Chang, Hun Soo ; Son, Kyu Ri ; Greenberg, Tsafrir ; Joe, Sook Haeng ; Lee, Min-Soo ; Ham, Byung-Joo. / Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder. In: Psychoneuroendocrinology. 2016 ; Vol. 72. pp. 147-155.
@article{d84b2b34ac224ba79e7c9795bb64e09e,
title = "Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder",
abstract = "We investigated the interactive effects of BclI C/G (rs41423247) allelic variants and the diagnosis of major depressive disorder (MDD) on hippocampal shape and integrity of the left parahippocampal subdivision of the cingulum. Fifty-two patients with MDD and 52 healthy controls (HCs) underwent T1-weighted structural magnetic resonance imaging and BclI C/G (rs41423247) genotyping. We analyzed hippocampal shape using the FIRST module of FSL and analyzed white matter (WM) integrity using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Significant alterations in left hippocampal shape and decreased fractional anisotropy (FA) values of the left parahippocampal cingulum were observed in MDD patients, compared to HCs. In addition, MDD patients of the BclI minor (G-) allele carrier group showed significant alterations in left hippocampal shape and decreased FA values of the left parahippocampal cingulum compared to BclI minor (G-) allele carrier HCs. No significant differences between diagnostic subgroups of the C/C homozygotes were observed. Our study provides evidence for alterations in hippocampal shape and decreased integrity of the WM region associated with the hippocampus in MDD, and for the possible influence of BclI C/G polymorphism (rs41423247) on hippocampal shape and integrity of the parahippocampal subdivision of the cingulum in depression.",
keywords = "BclI C/G (rs41423247), Hippocampus, Major depressive disorder, Parahippocampal cingulum",
author = "Eunsoo Won and June Kang and Aram Kim and Sunyoung Choi and Han, {Kyu Man} and Tae, {Woo Suk} and Chang, {Hun Soo} and Son, {Kyu Ri} and Tsafrir Greenberg and Joe, {Sook Haeng} and Min-Soo Lee and Byung-Joo Ham",
year = "2016",
month = "10",
day = "1",
doi = "10.1016/j.psyneuen.2016.07.008",
language = "English",
volume = "72",
pages = "147--155",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder

AU - Won, Eunsoo

AU - Kang, June

AU - Kim, Aram

AU - Choi, Sunyoung

AU - Han, Kyu Man

AU - Tae, Woo Suk

AU - Chang, Hun Soo

AU - Son, Kyu Ri

AU - Greenberg, Tsafrir

AU - Joe, Sook Haeng

AU - Lee, Min-Soo

AU - Ham, Byung-Joo

PY - 2016/10/1

Y1 - 2016/10/1

N2 - We investigated the interactive effects of BclI C/G (rs41423247) allelic variants and the diagnosis of major depressive disorder (MDD) on hippocampal shape and integrity of the left parahippocampal subdivision of the cingulum. Fifty-two patients with MDD and 52 healthy controls (HCs) underwent T1-weighted structural magnetic resonance imaging and BclI C/G (rs41423247) genotyping. We analyzed hippocampal shape using the FIRST module of FSL and analyzed white matter (WM) integrity using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Significant alterations in left hippocampal shape and decreased fractional anisotropy (FA) values of the left parahippocampal cingulum were observed in MDD patients, compared to HCs. In addition, MDD patients of the BclI minor (G-) allele carrier group showed significant alterations in left hippocampal shape and decreased FA values of the left parahippocampal cingulum compared to BclI minor (G-) allele carrier HCs. No significant differences between diagnostic subgroups of the C/C homozygotes were observed. Our study provides evidence for alterations in hippocampal shape and decreased integrity of the WM region associated with the hippocampus in MDD, and for the possible influence of BclI C/G polymorphism (rs41423247) on hippocampal shape and integrity of the parahippocampal subdivision of the cingulum in depression.

AB - We investigated the interactive effects of BclI C/G (rs41423247) allelic variants and the diagnosis of major depressive disorder (MDD) on hippocampal shape and integrity of the left parahippocampal subdivision of the cingulum. Fifty-two patients with MDD and 52 healthy controls (HCs) underwent T1-weighted structural magnetic resonance imaging and BclI C/G (rs41423247) genotyping. We analyzed hippocampal shape using the FIRST module of FSL and analyzed white matter (WM) integrity using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Significant alterations in left hippocampal shape and decreased fractional anisotropy (FA) values of the left parahippocampal cingulum were observed in MDD patients, compared to HCs. In addition, MDD patients of the BclI minor (G-) allele carrier group showed significant alterations in left hippocampal shape and decreased FA values of the left parahippocampal cingulum compared to BclI minor (G-) allele carrier HCs. No significant differences between diagnostic subgroups of the C/C homozygotes were observed. Our study provides evidence for alterations in hippocampal shape and decreased integrity of the WM region associated with the hippocampus in MDD, and for the possible influence of BclI C/G polymorphism (rs41423247) on hippocampal shape and integrity of the parahippocampal subdivision of the cingulum in depression.

KW - BclI C/G (rs41423247)

KW - Hippocampus

KW - Major depressive disorder

KW - Parahippocampal cingulum

UR - http://www.scopus.com/inward/record.url?scp=84978191176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978191176&partnerID=8YFLogxK

U2 - 10.1016/j.psyneuen.2016.07.008

DO - 10.1016/j.psyneuen.2016.07.008

M3 - Article

C2 - 27428087

AN - SCOPUS:84978191176

VL - 72

SP - 147

EP - 155

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -