Influence of chitosan coating on the liposomal surface on physicochemical properties and the release profile of nanocarrier systems

S. H. Bang, I. C. Hwang, Y. M. Yu, H. R. Kwon, D. H. Kim, Hyun Jin Park

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Chitosan-coated nanoliposomes containing etofenprox or alpha-cypermethrin prepared by ultrasonic homogenization maintained a size distribution in the nanometre range. Nanoliposomes were constructed using different types and concentrations of chitosan to regulate the mean size and surface charge. As the chitosan concentration (0.10.5%, w/v) and the degree of deacetylation increased, surface charge also increased. The encapsulation efficiency and release profile were measured by gas chromatography. Encapsulation efficiency decreased slightly as chitosan concentration increased (0.10.5%, w/v). As the intrinsic surface charge or concentration of the coating material increased, the release period of the entrapped core material was extended (chitosans A and B; 0.1 and 0.3%, w/v). The results indicate that diverse preparation conditions could affect the physicochemical properties and release profile of the resulting nanocarrier systems.

Original languageEnglish
Pages (from-to)595-604
Number of pages10
JournalJournal of Microencapsulation
Volume28
Issue number7
DOIs
Publication statusPublished - 2011 Nov 1

Keywords

  • Chitosan
  • Chitosan-coated liposome
  • Controlled release
  • Nanocarrier system
  • Phosphatidylcholine
  • Self-assembly

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Bioengineering
  • Organic Chemistry

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