Influence of food restriction combined with voluntary running on bone morphology and strength in male rats

Satoshi Hattori, Jonghoon Park, Umon Agata, Takayuki Akimoto, Masaya Oda, Michito Higano, Yuki Aikawa, Yoshiharu Nabekura, Hideyuki Yamato, Ikuko Ezawa, Naomi Omi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Athletes, in particular endurance athletes and dancers, are chronically exposed to a state of low energy availability due to insufficient dietary energy intake and massive exercise energy expenditure. Low energy availability sometimes causes bone fragility, thereby increasing the risk of bone disorders. Although the decrease in energy availability shows no sexual dimorphism, epidemiological studies have reported that bone disorders are less frequent in male athletes than in female athletes. We hypothesized that bone tissue was not affected by low energy availability in males. The purpose of this study was to examine the influence of food restriction combined with voluntary running training on bone morphology and strength in adult male rats. Fourteen-week-old male Sprague-Dawley rats were divided randomly into four groups: control (C) group, food restriction (R) group, exercise (Ex) group, and food restriction plus exercise (REx) group. For the R and REx groups, 30 % food restriction was carried out in comparison with the C group. Bone strength, bone mineral density (BMD), bone architecture, and bone turnover rate were measured after a 13-week experimental period. Bone strength was not significantly lower in the REx group compared with the C group. BMD and trabecular bone volume showed no difference among groups. These findings indicate that bone morphology and strength were little affected by food restriction combined with exercise training in adult male rats.

Original languageEnglish
Pages (from-to)540-548
Number of pages9
JournalCalcified Tissue International
Volume93
Issue number6
DOIs
Publication statusPublished - 2013 Dec 1
Externally publishedYes

Fingerprint

Running
Bone and Bones
Food
Exercise
Athletes
Bone Density
Bone Remodeling
Energy Intake
Sex Characteristics
Energy Metabolism
Sprague Dawley Rats
Epidemiologic Studies
Control Groups

Keywords

  • Bone mineral density
  • Bone morphology
  • Bone strength
  • Bone turnover
  • Low energy availability

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Influence of food restriction combined with voluntary running on bone morphology and strength in male rats. / Hattori, Satoshi; Park, Jonghoon; Agata, Umon; Akimoto, Takayuki; Oda, Masaya; Higano, Michito; Aikawa, Yuki; Nabekura, Yoshiharu; Yamato, Hideyuki; Ezawa, Ikuko; Omi, Naomi.

In: Calcified Tissue International, Vol. 93, No. 6, 01.12.2013, p. 540-548.

Research output: Contribution to journalArticle

Hattori, S, Park, J, Agata, U, Akimoto, T, Oda, M, Higano, M, Aikawa, Y, Nabekura, Y, Yamato, H, Ezawa, I & Omi, N 2013, 'Influence of food restriction combined with voluntary running on bone morphology and strength in male rats', Calcified Tissue International, vol. 93, no. 6, pp. 540-548. https://doi.org/10.1007/s00223-013-9787-6
Hattori, Satoshi ; Park, Jonghoon ; Agata, Umon ; Akimoto, Takayuki ; Oda, Masaya ; Higano, Michito ; Aikawa, Yuki ; Nabekura, Yoshiharu ; Yamato, Hideyuki ; Ezawa, Ikuko ; Omi, Naomi. / Influence of food restriction combined with voluntary running on bone morphology and strength in male rats. In: Calcified Tissue International. 2013 ; Vol. 93, No. 6. pp. 540-548.
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