Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia

Concetta Crisafulli, Alberto Chiesa, Diana De Ronchi, Changsu Han, Soo Jung Lee, Moon Ho Park, Ashwin A. Patkar, Chi Un Pae, Alessandro Serretti

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. One hundred forty five patients with MD, 221 in-patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. No significant association was found with the diagnosis of schizophrenia. We observed an association between rs3813296 genotype and improvement on PANSS negative scores. Our findings provide no evidence for an association between SNPs within GRIA1, GRIA2 and GRIA4 under investigation and schizophrenia susceptibility, although rs3813296 (GRIA2) could be associated with improvement on PANSS negative scores. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.

    Original languageEnglish
    Pages (from-to)170-174
    Number of pages5
    JournalNeuroscience Letters
    Volume506
    Issue number1
    DOIs
    Publication statusPublished - 2012 Jan 6

    Keywords

    • Antipsychotics
    • GRIA1
    • GRIA2
    • GRIA4
    • Glutamate receptors
    • Schizophrenia

    ASJC Scopus subject areas

    • Neuroscience(all)

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