TY - JOUR
T1 - Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia
AU - Crisafulli, Concetta
AU - Chiesa, Alberto
AU - De Ronchi, Diana
AU - Han, Changsu
AU - Lee, Soo Jung
AU - Park, Moon Ho
AU - Patkar, Ashwin A.
AU - Pae, Chi Un
AU - Serretti, Alessandro
PY - 2012/1/6
Y1 - 2012/1/6
N2 - The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. One hundred forty five patients with MD, 221 in-patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. No significant association was found with the diagnosis of schizophrenia. We observed an association between rs3813296 genotype and improvement on PANSS negative scores. Our findings provide no evidence for an association between SNPs within GRIA1, GRIA2 and GRIA4 under investigation and schizophrenia susceptibility, although rs3813296 (GRIA2) could be associated with improvement on PANSS negative scores. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.
AB - The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. One hundred forty five patients with MD, 221 in-patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. No significant association was found with the diagnosis of schizophrenia. We observed an association between rs3813296 genotype and improvement on PANSS negative scores. Our findings provide no evidence for an association between SNPs within GRIA1, GRIA2 and GRIA4 under investigation and schizophrenia susceptibility, although rs3813296 (GRIA2) could be associated with improvement on PANSS negative scores. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.
KW - Antipsychotics
KW - Glutamate receptors
KW - GRIA1
KW - GRIA2
KW - GRIA4
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=84855195512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855195512&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2011.10.074
DO - 10.1016/j.neulet.2011.10.074
M3 - Article
C2 - 22094384
AN - SCOPUS:84855195512
VL - 506
SP - 170
EP - 174
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -