Abstract
Object. Peritumoral brain edema (PTBE) is associated with perioperative neurological deficits in patients with meningiomas. However, the pathogenesis of meningioma-associated edema remains unclear. In the present study, the authors investigated the expression of interleukin-6 (IL-6) and its relationship with PTBE in resected meningiomas. Methods. Thirty-six benign meningiomas obtained in 36 patients were studied retrospectively. Edema volume was assessed on MR images, and an edema index (EI) was calculated. Interleukin-6 mRNA and protein expression were examined by real-time reverse transcriptase polymerase chain reaction and immunohistochemical staining. Results. Peritumoral brain edema was found in 16 patients (44%). Neither age, sex, histological subtype, nor tumor location were related to PTBE. The level of IL-6 mRNA was 7.72 times greater in the edema group (EI > 0.2) than in the nonedema group (EI < 0.2; p = 0.011). On immunohistochemical analysis, IL-6 protein was found localized in the cytoplasm of the tumor cells, and was detected in 12 (75%) of 16 cases of edematous meningiomas, but in only 6 (30%) of 20 nonedematous cases. There was a significant correlation between the severity of PTBE and IL-6 expression (p = 0.004). Conclusions. The authors' results in this study indicate that IL-6 expression may contribute to the development of brain edema associated with meningiomas.
| Original language | English |
|---|---|
| Pages (from-to) | 73-80 |
| Number of pages | 8 |
| Journal | Journal of Neurosurgery |
| Volume | 112 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 Jan 1 |
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Keywords
- Interleukin-6
- Meningioma
- Peritumoral brain edema
ASJC Scopus subject areas
- Surgery
- Clinical Neurology
Cite this
Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas : Laboratory investigation. / Park, Kyung-Jae; Kang, Shin-Hyuk; Chae, Yang Seok; Yu, Mi Ok; Cho, Tai Hyoung; Suh, Jung Keun; Lee, Hoon Kap; Chung, Yong Gu.
In: Journal of Neurosurgery, Vol. 112, No. 1, 01.01.2010, p. 73-80.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas
T2 - Laboratory investigation
AU - Park, Kyung-Jae
AU - Kang, Shin-Hyuk
AU - Chae, Yang Seok
AU - Yu, Mi Ok
AU - Cho, Tai Hyoung
AU - Suh, Jung Keun
AU - Lee, Hoon Kap
AU - Chung, Yong Gu
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Object. Peritumoral brain edema (PTBE) is associated with perioperative neurological deficits in patients with meningiomas. However, the pathogenesis of meningioma-associated edema remains unclear. In the present study, the authors investigated the expression of interleukin-6 (IL-6) and its relationship with PTBE in resected meningiomas. Methods. Thirty-six benign meningiomas obtained in 36 patients were studied retrospectively. Edema volume was assessed on MR images, and an edema index (EI) was calculated. Interleukin-6 mRNA and protein expression were examined by real-time reverse transcriptase polymerase chain reaction and immunohistochemical staining. Results. Peritumoral brain edema was found in 16 patients (44%). Neither age, sex, histological subtype, nor tumor location were related to PTBE. The level of IL-6 mRNA was 7.72 times greater in the edema group (EI > 0.2) than in the nonedema group (EI < 0.2; p = 0.011). On immunohistochemical analysis, IL-6 protein was found localized in the cytoplasm of the tumor cells, and was detected in 12 (75%) of 16 cases of edematous meningiomas, but in only 6 (30%) of 20 nonedematous cases. There was a significant correlation between the severity of PTBE and IL-6 expression (p = 0.004). Conclusions. The authors' results in this study indicate that IL-6 expression may contribute to the development of brain edema associated with meningiomas.
AB - Object. Peritumoral brain edema (PTBE) is associated with perioperative neurological deficits in patients with meningiomas. However, the pathogenesis of meningioma-associated edema remains unclear. In the present study, the authors investigated the expression of interleukin-6 (IL-6) and its relationship with PTBE in resected meningiomas. Methods. Thirty-six benign meningiomas obtained in 36 patients were studied retrospectively. Edema volume was assessed on MR images, and an edema index (EI) was calculated. Interleukin-6 mRNA and protein expression were examined by real-time reverse transcriptase polymerase chain reaction and immunohistochemical staining. Results. Peritumoral brain edema was found in 16 patients (44%). Neither age, sex, histological subtype, nor tumor location were related to PTBE. The level of IL-6 mRNA was 7.72 times greater in the edema group (EI > 0.2) than in the nonedema group (EI < 0.2; p = 0.011). On immunohistochemical analysis, IL-6 protein was found localized in the cytoplasm of the tumor cells, and was detected in 12 (75%) of 16 cases of edematous meningiomas, but in only 6 (30%) of 20 nonedematous cases. There was a significant correlation between the severity of PTBE and IL-6 expression (p = 0.004). Conclusions. The authors' results in this study indicate that IL-6 expression may contribute to the development of brain edema associated with meningiomas.
KW - Interleukin-6
KW - Meningioma
KW - Peritumoral brain edema
UR - http://www.scopus.com/inward/record.url?scp=75749101068&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75749101068&partnerID=8YFLogxK
U2 - 10.3171/2009.4.JNS09158
DO - 10.3171/2009.4.JNS09158
M3 - Article
VL - 112
SP - 73
EP - 80
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - 1
ER -