Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas

Laboratory investigation

Kyung-Jae Park, Shin-Hyuk Kang, Yang Seok Chae, Mi Ok Yu, Tai Hyoung Cho, Jung Keun Suh, Hoon Kap Lee, Yong Gu Chung

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Object. Peritumoral brain edema (PTBE) is associated with perioperative neurological deficits in patients with meningiomas. However, the pathogenesis of meningioma-associated edema remains unclear. In the present study, the authors investigated the expression of interleukin-6 (IL-6) and its relationship with PTBE in resected meningiomas. Methods. Thirty-six benign meningiomas obtained in 36 patients were studied retrospectively. Edema volume was assessed on MR images, and an edema index (EI) was calculated. Interleukin-6 mRNA and protein expression were examined by real-time reverse transcriptase polymerase chain reaction and immunohistochemical staining. Results. Peritumoral brain edema was found in 16 patients (44%). Neither age, sex, histological subtype, nor tumor location were related to PTBE. The level of IL-6 mRNA was 7.72 times greater in the edema group (EI > 0.2) than in the nonedema group (EI < 0.2; p = 0.011). On immunohistochemical analysis, IL-6 protein was found localized in the cytoplasm of the tumor cells, and was detected in 12 (75%) of 16 cases of edematous meningiomas, but in only 6 (30%) of 20 nonedematous cases. There was a significant correlation between the severity of PTBE and IL-6 expression (p = 0.004). Conclusions. The authors' results in this study indicate that IL-6 expression may contribute to the development of brain edema associated with meningiomas.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalJournal of Neurosurgery
Volume112
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

Fingerprint

Brain Edema
Meningioma
Interleukin-6
Edema
Messenger RNA
Reverse Transcriptase Polymerase Chain Reaction
Real-Time Polymerase Chain Reaction
Neoplasms
Cytoplasm
Proteins
Staining and Labeling

Keywords

  • Interleukin-6
  • Meningioma
  • Peritumoral brain edema

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

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title = "Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas: Laboratory investigation",
abstract = "Object. Peritumoral brain edema (PTBE) is associated with perioperative neurological deficits in patients with meningiomas. However, the pathogenesis of meningioma-associated edema remains unclear. In the present study, the authors investigated the expression of interleukin-6 (IL-6) and its relationship with PTBE in resected meningiomas. Methods. Thirty-six benign meningiomas obtained in 36 patients were studied retrospectively. Edema volume was assessed on MR images, and an edema index (EI) was calculated. Interleukin-6 mRNA and protein expression were examined by real-time reverse transcriptase polymerase chain reaction and immunohistochemical staining. Results. Peritumoral brain edema was found in 16 patients (44{\%}). Neither age, sex, histological subtype, nor tumor location were related to PTBE. The level of IL-6 mRNA was 7.72 times greater in the edema group (EI > 0.2) than in the nonedema group (EI < 0.2; p = 0.011). On immunohistochemical analysis, IL-6 protein was found localized in the cytoplasm of the tumor cells, and was detected in 12 (75{\%}) of 16 cases of edematous meningiomas, but in only 6 (30{\%}) of 20 nonedematous cases. There was a significant correlation between the severity of PTBE and IL-6 expression (p = 0.004). Conclusions. The authors' results in this study indicate that IL-6 expression may contribute to the development of brain edema associated with meningiomas.",
keywords = "Interleukin-6, Meningioma, Peritumoral brain edema",
author = "Kyung-Jae Park and Shin-Hyuk Kang and Chae, {Yang Seok} and Yu, {Mi Ok} and Cho, {Tai Hyoung} and Suh, {Jung Keun} and Lee, {Hoon Kap} and Chung, {Yong Gu}",
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T1 - Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas

T2 - Laboratory investigation

AU - Park, Kyung-Jae

AU - Kang, Shin-Hyuk

AU - Chae, Yang Seok

AU - Yu, Mi Ok

AU - Cho, Tai Hyoung

AU - Suh, Jung Keun

AU - Lee, Hoon Kap

AU - Chung, Yong Gu

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N2 - Object. Peritumoral brain edema (PTBE) is associated with perioperative neurological deficits in patients with meningiomas. However, the pathogenesis of meningioma-associated edema remains unclear. In the present study, the authors investigated the expression of interleukin-6 (IL-6) and its relationship with PTBE in resected meningiomas. Methods. Thirty-six benign meningiomas obtained in 36 patients were studied retrospectively. Edema volume was assessed on MR images, and an edema index (EI) was calculated. Interleukin-6 mRNA and protein expression were examined by real-time reverse transcriptase polymerase chain reaction and immunohistochemical staining. Results. Peritumoral brain edema was found in 16 patients (44%). Neither age, sex, histological subtype, nor tumor location were related to PTBE. The level of IL-6 mRNA was 7.72 times greater in the edema group (EI > 0.2) than in the nonedema group (EI < 0.2; p = 0.011). On immunohistochemical analysis, IL-6 protein was found localized in the cytoplasm of the tumor cells, and was detected in 12 (75%) of 16 cases of edematous meningiomas, but in only 6 (30%) of 20 nonedematous cases. There was a significant correlation between the severity of PTBE and IL-6 expression (p = 0.004). Conclusions. The authors' results in this study indicate that IL-6 expression may contribute to the development of brain edema associated with meningiomas.

AB - Object. Peritumoral brain edema (PTBE) is associated with perioperative neurological deficits in patients with meningiomas. However, the pathogenesis of meningioma-associated edema remains unclear. In the present study, the authors investigated the expression of interleukin-6 (IL-6) and its relationship with PTBE in resected meningiomas. Methods. Thirty-six benign meningiomas obtained in 36 patients were studied retrospectively. Edema volume was assessed on MR images, and an edema index (EI) was calculated. Interleukin-6 mRNA and protein expression were examined by real-time reverse transcriptase polymerase chain reaction and immunohistochemical staining. Results. Peritumoral brain edema was found in 16 patients (44%). Neither age, sex, histological subtype, nor tumor location were related to PTBE. The level of IL-6 mRNA was 7.72 times greater in the edema group (EI > 0.2) than in the nonedema group (EI < 0.2; p = 0.011). On immunohistochemical analysis, IL-6 protein was found localized in the cytoplasm of the tumor cells, and was detected in 12 (75%) of 16 cases of edematous meningiomas, but in only 6 (30%) of 20 nonedematous cases. There was a significant correlation between the severity of PTBE and IL-6 expression (p = 0.004). Conclusions. The authors' results in this study indicate that IL-6 expression may contribute to the development of brain edema associated with meningiomas.

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